Unlocking Longevity and Energy: The Power of NAD+ Supplementation

Feeling the effects of aging, like low energy and mental fog? NAD+, a vital molecule in your cells, naturally declines as you get older, and this could be the reason. Research suggests NAD+ supplements hold the potential to support energy production, healthier aging, and even combat chronic inflammation.

Feeling a persistent lack of energy, or finding focus harder to grasp? It could be related to NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in all your cells. NAD+ plays a starring role in the intricate dance of cellular metabolism – the process of turning food into energy. It's also critical for DNA repair, numerous signaling pathways, and countless other processes that support overall well-being.

The challenge is that our NAD+ levels naturally decline as we age. This decline contributes to changes like decreased cellular energy production, potential cognitive slowing, and vulnerability to disease. However, the exciting news is that NAD+ supplements show promise in reversing some of these effects, potentially supporting greater longevity and day-to-day vitality.

The origins of NAD+ supplementation trace back to the transformative discoveries of the early 20th century. Scientists like Arthur Harden and William John Young pioneered research into essential compounds they termed 'vitamins,' ultimately revealing the vital role of NAD+ precursors. Subsequent decades of meticulous research have unveiled the profound importance of NAD+ at the very heart of cellular function. 

At Mito Health, we help you understand your unique cellular health profile, through the use of advanced biomarkers. Your personalized screening results might indicate a potential benefit from exploring NAD+ supplementation as part of your overall wellness strategy.

TLDR;

  • NAD+ is essential for cellular health: This molecule powers energy production, DNA repair, and many vital processes. Levels decline with age, impacting overall wellbeing
  • NAD+ fights aging: Boosting NAD+ may reduce fatigue, potentially improve cognition, and support cellular function, contributing to a more vibrant experience of aging.
  • NAD+ and inflammation: NAD+ is crucial for regulating inflammation, which underlies many age-related diseases. Supplementation could potentially be protective.
  • Daily energy and focus: NAD+ supports healthy energy production and brain function, helping you feel more energized and mentally sharper.
  • Understanding supplementation: NAD+ supplements come in various forms (NR, NMN, etc.) Choosing reputable brands, safe dosages, and seeking professional guidance are key.

Combating Aging with NAD+: The Science Speaks

Our cells contain miniature powerhouses called mitochondria, and they rely heavily on NAD+ to function optimally. As we age, NAD+ levels fall, and our mitochondria become less efficient. It's like the lights dimming inside each cell. This mitochondrial dysfunction fuels many age-related processes, including decreased energy output, potential cognitive decline, and less efficient cellular repair.

Professor Vincenzo Sorrentino's groundbreaking studies have pinpointed NAD+ depletion as a key driver of mitochondrial decline. His research shows that NAD+ precursors, like NMN, revitalize mitochondria. Importantly, these supplements also combat cellular senescence, a process where cells become sluggish and less efficient. These findings point to NAD+ supplementation as a potent tool for healthy aging. It's a bit like recharging the batteries of our cells for more robust energy production and longer-lasting cellular function.

We hosted Professor Vincenzo at our last Mandala talk; where he presented his latest research into NAD+ supplementation.

Consumption of NAD+ is linked to inflammation

NAD+ plays a crucial role in regulating inflammation, a process central to many chronic and age-related diseases. Here's how:

  • Declining NAD+ levels can contribute to chronic inflammation, a hallmark of many age-related diseases. This is due to increased activity of NAD+ consuming enzymes, further depleting NAD+ stores.
  • NAD+ is essential for the function of sirtuins, proteins that help suppress inflammatory responses. Lower NAD+ levels reduce sirtuin activity, potentially worsening inflammation.
  • Studies indicate that NAD+ precursors may help reduce inflammatory responses and protect against tissue damage caused by chronic inflammation, offering potential benefits in areas such as cardiovascular disease, neurodegenerative diseases, and certain cancers.

Beyond Anti-Aging: NAD+ for Everyday Energy and Wellness

NAD+'s power isn't just about turning back the clock. Think of it as the spark plug for the intricate cellular machinery that turns the food you eat into energy. By supplementing with NAD+, we might enhance day-to-day energy levels and fend off fatigue. Studies on NAD+ show a noticeable energy boost due to its role in the Krebs cycle, a key energy-generating metabolic pathway.

Furthermore, NAD+ is vital for brain health. Research indicates that boosting NAD+ levels might aid cognition. For example, a 2021 study found older individuals supplementing with an NAD+ precursor experienced improvements in processing speed and attention - crucial components of overall focus and clarity. A separate trial published in 2017 demonstrated the potential of NAD+ precursors in mitigating neurodegenerative processes associated with Alzheimer's disease.

Understanding NAD+ Supplements: How do I start?

  • Unveiling NAD+ Precursors: The most common NAD+ precursors are nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). These molecules are converted into NAD+ within the body. NMN may work slightly faster, while NR has a strong track record in human studies. You may also come across trigonelline, found naturally in coffee beans and other plants. Trigonelline contributes indirectly to NAD+ production, and might have unique benefits for blood sugar management.

  • Safe Supplementation: Begin with a lower dose (e.g., 250mg of NR or NMN) and gradually increase as tolerated. Seek guidance from your healthcare provider, especially if you have underlying health conditions. For optimal benefit, combine NAD+ supplementation with a balanced diet, regular exercise, and restful sleep.

  • A Typical Regimen: Most individuals take a single dose per day, preferably in the morning. Optimal dosages can vary, with the effective range being between 250mg to 1000mg daily for many NAD+ precursors.
  • Opt for brands known for quality, such as Thorne Research, Quicksilver Scientific, Tru Niagen, or ProHealth Longevity.
  • The research is putative, but promising: While more clinical research is needed to definitively confirm all the proposed benefits, the existing body of research on NAD+ supplementation is incredibly promising – studies (especially in animal models) show potential for supporting healthy aging, combating age-related declines in energy and cognition, reducing inflammation, and even offering protection against chronic diseases.

In closing 

NAD+ is a powerhouse molecule within our bodies, and while the science on its long-term benefits is ongoing, research suggests it has the potential to support healthy aging, energy levels, and overall wellness. Want to understand your unique cellular health profile and whether exploring NAD+ supplementation could be beneficial for you? Consider Mito Health's flagship package. Our personalized screening, coupled with expert guidance, can empower you to make informed decisions about incorporating NAD+ into your wellness strategy. Reach out and let's explore your potential together!

References

Imai, S. I., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464-471. https://doi.org/10.1016/j.tcb.2014.04.002

Davis, C. C., Marti, G. N., & Brenner, C. (2020). The interplay between NAD+ metabolism and inflammation. International journal of molecular sciences, 21(16), 5698.

Sorrentino, V., Menzies, K. J., & Auwerx, J. (2018). Repairing mitochondrial dysfunction in disease. Annual Review of Pharmacology and Toxicology, 58, 353-389. [invalid URL removed]

Camacho-Pereira, J., Tarragó, M. G., Chini, C. C., Nin, V., Escande, C., Warner, G. M., ... & Chini, E. N. (2016). CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metabolism, 23(6), 1127-1139. https://doi.org/10.1016/j.cmet.2016.05.006

Written By
Gabriel Sim
May 3, 2024
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