Complete Blood Count (CBC) with Differential and Platelet Count
A broad screen of red cells, white cells, and platelets that anchors most checkups.
Consider this test if:
- Unexplained fatigue, weakness, shortness of breath, or poor exercise tolerance
- Frequent infections, easy bruising, or unusual bleeding
- Setting a general health baseline or tracking changes year to year
- Following up an abnormal red-cell, white-cell, or platelet result
- Monitoring how the body responds to a medication, treatment, or iron repletion
- HSA/FSA eligible
- Typical results in 1 day · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required. Recent intense exercise, acute infection, dehydration, and some medications can temporarily shift white-cell and platelet counts, so for tracking, draw under similar conditions each time.
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What this test is for
The CBC with differential measures the three major cell lines in blood: red blood cells (hemoglobin, hematocrit, MCV, RDW), white blood cells broken out by type (neutrophils, lymphocytes, monocytes, eosinophils, basophils), and platelets. Low hemoglobin or hematocrit points to anemia and is commonly checked when investigating fatigue, weakness, shortness of breath, or poor exercise tolerance, while red-cell indices like MCV help sort iron deficiency from B12 or folate deficiency. The white-cell differential flags infection, inflammation, allergy, and rarely blood cancers such as leukemia, and elevated eosinophils can accompany allergic or parasitic conditions. Platelet count reflects clotting capacity, with low values raising bleeding risk and high values seen with inflammation or marrow disorders. It is one of the most useful baseline panels to track over time, since shifts across visits often surface before symptoms do.
Biomarkers tested
Includes 51 biomarkers
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
Band neutrophils are immature neutrophils released early from the bone marrow when the body needs backup fast, still finishing their development while already heading out to fight infection. A normal count means the marrow isn't under pressure. An elevated count, often called a left shift, signals an active bacterial infection, inflammation, or significant physical stress and often shows up alongside fever, fatigue, or a suspected infection that needs to be tracked down.
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number fraction (%)
Blasts are immature precursor cells that normally stay in the bone marrow, maturing before they enter circulation. Finding them in blood is abnormal at any meaningful number and points toward a bone marrow disorder, most seriously leukemia, where the marrow releases these unfinished cells before they are ready to defend, clear, or carry anything properly. This test is used diagnostically, alongside a full blood count and clinical picture, when something else (unexplained fatigue, bruising, infections, abnormal counts) has already raised concern.
- Specimen
- Whole blood
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Number fraction (%)
Elliptocytes are red blood cells shaped like ellipses instead of the usual disc, spotted when a lab technician examines your blood smear under a light microscope. A few can appear normally, but a significant number points to a membrane defect, most often hereditary elliptocytosis, or to iron deficiency, thalassemia, or other bone marrow disorders that disrupt how red cells are built. This test is typically ordered to investigate unexplained anemia, fatigue, or abnormal red cell counts, helping pin down why your red blood cells aren't holding their normal shape.
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number fraction (%)
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Distribution width
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
Granulocytes, mostly neutrophils with smaller numbers of eosinophils and basophils, are the white cells that rush to sites of infection or injury and attack bacteria and other invaders. This manual count reports what fraction of your white cells are granulocytes, useful for confirming automated counts and getting an accurate read when cell populations look unusual under the microscope. A result outside the expected range points toward active infection, inflammation, or a bone marrow issue and is typically read alongside your full white cell differential rather than on its own.
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Number fraction (%)
Hematocrit measures the percentage of your blood volume made up of red blood cells, the cells that carry oxygen from your lungs to every tissue. Low hematocrit points to anemia and pairs with fatigue, breathlessness, dizziness, or poor exercise tolerance, while high hematocrit can reflect dehydration, high altitude, smoking, or overactive red cell production, and thickens blood in ways that matter for cardiovascular risk. It's a core piece of the complete blood count, useful as a baseline read on oxygen-carrying capacity and for tracking how iron status, training, or altitude exposure are shifting your blood over time.
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Volume fraction (%)
- Specimen
- Whole blood
- Measures
- Mass concentration
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
Immature granulocytes are young neutrophils, eosinophils, and basophils that bone marrow releases early when it's ramping up production, cells that haven't fully matured before entering circulation. A raised percentage signals the marrow is working overtime, most often because of an active bacterial infection, inflammation, or physiological stress, and it tends to rise before other markers catch up, making it a fast early flag when you're feeling unwell with fever, fatigue, or signs of infection. For proactive tracking, a normal result alongside a routine CBC confirms your marrow isn't under acute strain.
- Specimen
- Whole blood
- Measures
- Number fraction (%)
Large granular lymphocytes are the natural killer cells and cytotoxic T cells that patrol the blood, hunting down virus-infected cells and abnormal cells before they become a problem. This count is rarely ordered as routine screening, it's typically pulled when a full blood count or clinical picture suggests LGL leukemia or a related chronic lymphoproliferative disorder, especially alongside unexplained neutropenia, anemia, or recurrent infections. An elevated count warrants follow-up with flow cytometry to characterize the cell population and confirm what's driving the expansion.
- Specimen
- Whole blood
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number fraction (%)
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
Mean platelet volume measures the average size of your platelets, the cell fragments that plug injured vessels and stop bleeding. Larger platelets are younger, freshly released from bone marrow, and more reactive, so a high MPV often signals increased platelet turnover from inflammation, iron deficiency, or clotting risk, while a low MPV points to reduced marrow production or older, less active platelets. Paired with your platelet count, MPV helps distinguish why a platelet number is off and adds useful context if you're investigating easy bruising, unexplained clotting, or inflammatory conditions.
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Mean cell volume
Megakaryocytic nuclei are a manual smear finding that flags when the bone marrow cells responsible for producing platelets show up in circulating blood, where they don't belong. Their presence signals marrow stress or a disorder pushing immature cells out early, and it's typically picked up when a blood smear is reviewed to investigate abnormal platelet counts, unexplained bleeding or clotting, or other irregularities on a CBC. This isn't a routine wellness check, it's a targeted microscopy finding your doctor orders to chase down what a standard blood count can't explain.
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Number fraction (%)
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
Mononuclear cells are the lymphocytes and monocytes in your differential, the cells that recognize threats, produce antibodies, and clean up debris and dying tissue. This manual count expresses them as a fraction of total white cells, useful for confirming automated differential results or getting an accurate read when abnormal or immature cells make automated counting unreliable. A shifted mononuclear fraction shows up in viral infections, chronic inflammation, and certain blood disorders, and helps explain fatigue, swollen lymph nodes, or a white count that doesn't add up.
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Number fraction (%)
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Number fraction (%)
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Number fraction (%)
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Number concentration
This manual count compares nucleated red blood cells to white blood cells, giving the lab a precise ratio used to correct your white blood cell count when immature red cells are present in circulation. Nucleated RBCs normally stay locked in the bone marrow until they mature and shed their nucleus, so finding them in blood signals the marrow is under stress, pushed out early by severe anemia, hemolysis, bone marrow disorders, or low oxygen states. This isn't a standalone wellness check, it's a technical follow-up your lab runs to keep your white cell count accurate whenever nucleated RBCs turn up on a differential.
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Ratio
- Specimen
- Red blood cells
- Method
- Automated cell count
- Measures
- Mean cell volume
This is a catch-all flag from your automated blood count, capturing unusual cells that don't sort cleanly into the standard white cell categories (neutrophils, lymphocytes, monocytes, eosinophils, basophils). A nonzero result doesn't diagnose anything on its own, it tells the lab's analyzer that something atypical, like blasts, abnormal lymphocytes, or other irregular cells, showed up and usually triggers a manual review under the microscope. If you're already investigating unexplained fatigue, bruising, infections, or a suspicious complete blood count, this value tells you whether a closer look is warranted.
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
This captures white blood cells that fall outside the standard five-type differential (neutrophils, lymphocytes, monocytes, eosinophils, basophils), typically immature or atypical cells that an automated analyzer flags but can't cleanly classify. A nonzero count usually prompts a manual smear review to identify what's actually circulating, since it can reflect anything from a reactive response to infection to something that warrants closer hematology follow-up. This isn't a marker people track for wellness purposes, it's a quality flag your lab uses to decide whether your blood needs a closer look.
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
This test examines a blood smear under the microscope for parasites that invade red blood cells, most notably the organisms that cause malaria, babesiosis, and related infections. It's the standard workup when someone develops fevers, chills, sweats, fatigue, or a recent travel history to a malaria-endemic region raises suspicion of a blood-borne parasite. A positive result identifies the organism directly, which guides urgent treatment, while a negative result helps rule out parasitic infection as the cause of unexplained fever.
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Identity
Platelet count estimates how many clotting cells circulate in your blood, the fragments that rush to a cut or vessel injury and clump together to form a plug. Low counts (thrombocytopenia) show up as easy bruising, frequent nosebleeds, gum bleeding, or heavy periods, and can stem from bone marrow issues, autoimmune destruction, viral infection, or spleen problems. High counts can signal inflammation, iron deficiency, or a bone marrow disorder pushing out too many, so this is a useful baseline check as well as a first step in explaining unusual bleeding or bruising.
- Specimen
- Whole blood
- Method
- Estimated
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
Polychromasia is what a technologist sees under the microscope when young red blood cells, still tinted blue-grey from residual RNA, show up in your blood smear. Their presence tells you the bone marrow is releasing cells faster than usual, typically because it's compensating for blood loss or hemolysis (red cells being destroyed early), or responding to iron, B12, or folate treatment. It's a useful confirmation alongside reticulocyte count when investigating unexplained anemia, fatigue, or pallor, and it helps distinguish a marrow actively regenerating from one that's underproducing.
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Number fraction (%)
- Specimen
- Whole blood
- Method
- Manual cell count
- Measures
- Number fraction (%)
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
Siderocytes are red blood cells caught holding onto free iron granules instead of packaging that iron properly into hemoglobin, and this count reflects how well your bone marrow handles iron during red cell production. Elevated siderocytes point to impaired iron utilization, seen in sideroblastic anemias, lead exposure, certain myelodysplastic conditions, or after splenectomy (since the spleen normally clears these iron remnants from circulation). This is a specialized follow-up test, not a routine screen: it's ordered when a CBC or iron panel shows an unexplained anemia pattern that needs a closer look at how iron is actually being handled inside developing red cells.
- Specimen
- Whole blood
- Measures
- Number concentration
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
Stomatocytes are red blood cells that carry a mouth-shaped slit across their surface instead of the usual central dot, a shape change that shows up when a technologist examines your blood smear under the microscope. Their presence points to conditions that disrupt the cell membrane's balance of sodium and potassium, including hereditary stomatocytosis, liver disease, and heavy alcohol use, and can also appear as an artifact of sample handling. This test is typically ordered to help explain unexplained anemia or hemolysis rather than for routine baseline screening, and it works alongside a CBC and reticulocyte count to pin down the cause.
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
This tells your lab technician whether neutrophils, the white blood cells that engulf and destroy bacteria, show vacuoles (small internal bubbles) when examined under the microscope. Vacuolization signals that neutrophils are under stress, most often from active bacterial infection or sepsis, though toxic exposures and certain bone marrow disorders can produce the same pattern. This isn't a marker you order on its own, it surfaces as a called-out finding on a blood smear when something in your CBC warrants a closer look, and it helps confirm or rule out a significant infectious process.
- Specimen
- Whole blood
- Method
- Light microscopy
- Measures
- Presence / threshold
Variant lymphocytes (also called reactive or atypical lymphocytes) are lymphocytes that have changed shape and activity in response to a viral fight, most often Epstein-Barr virus (mono) but also CMV, hepatitis, or other infections. This percentage flags an active or recent viral immune response and helps explain fatigue, sore throat, swollen glands, or prolonged low energy that a standard white cell count leaves unexplained. A rise here alongside symptoms typically prompts follow-up testing for mono or other viral causes rather than assuming the fatigue is lifestyle-driven.
- Specimen
- Whole blood
- Method
- Automated cell count
- Measures
- Number fraction (%)
What to expect
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- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 1 day
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost — covering the lab and what it takes to run the service — never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9/mo, and you still pay the lab’s order fee. Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results post to your dashboard once your lab completes them, then a clinician reviews them and your full analysis and personalized action plan (with clear next steps) follow. Turnaround varies by test: specialty assays and at-home kits take longer, and each test shows its expected turnaround before you buy.
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No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.
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