Homocysteine
An amino acid tied to B-vitamin metabolism and cardiovascular risk that routine cholesterol panels do not capture.
Consider this test if:
- Cardiovascular disease risk assessment beyond a standard lipid panel, especially with a family history of early heart disease or stroke
- Investigating fatigue, numbness, weakness, or cognitive changes that point toward B12 or folate deficiency
- A known MTHFR variant or a personal or family history of blood clots
- Tracking whether B-vitamin repletion is bringing an elevated level down
- HSA/FSA eligible
- Typical results in 1-2 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
A fasting specimen is preferred to establish a baseline or monitor treatment. B12, B6, or folate supplements raise the variables behind this result, so note your dose and timing. Several medications (including niacin, methotrexate, theophylline, and L-dopa) can elevate levels.
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What this test is for
Homocysteine is an amino acid the body normally clears using vitamins B12, B6, and folate, so the level reflects how well that methylation pathway is working. High levels point to B12 or folate deficiency, and are also linked to impaired kidney function, hypothyroidism, advanced age, and certain medications. Elevated homocysteine is an independent risk factor for cardiovascular disease, with higher levels seen in heart disease, stroke, peripheral vascular disease, and thromboembolic disease; rarer inherited enzyme defects (such as cystathionine-beta-synthase deficiency or an MTHFR variant) can also raise it. Lowering the number with B vitamins does not by itself guarantee lower cardiovascular risk, so treat it as a marker rather than a target to chase.
If the goal is specifically to sort out a suspected B12 deficiency, the Methylmalonic Acid and Homocysteine Panel pairs this marker with MMA, which together separate B12 deficiency from folate deficiency more cleanly than homocysteine alone.
- Specimen
- Serum or plasma
- Measures
- Substance concentration
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 1-2 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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Without membership
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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