What is Cancer Antigen (CA125)?

Cancer Antigen 125 (CA125) is a protein found on the surface of many ovarian cancer cells and, to a lesser extent, on other cell types. CA125 is released into the bloodstream and can be measured with a blood test, primarily to monitor ovarian cancer progression or response to treatment.‍It is not exclusive to ovarian cancer, however, and can be elevated in other conditions, such as endometriosis, menstruation, and certain other cancers or inflammatory conditions.

What does it assess?

CA125 levels are primarily used as a marker to assess and monitor ovarian cancer. Elevated levels can indicate the presence of cancerous cells, particularly in individuals already diagnosed with ovarian cancer, where it helps track treatment effectiveness and detect potential recurrence.‍However, because CA125 can be elevated in various benign conditions, it is generally not used as a primary screening tool for ovarian cancer but rather as a supplementary test or monitoring tool.

How do I optimize my Cancer Antigen (CA125) levels?

Since CA125 can increase due to inflammation, managing chronic inflammation with a balanced diet rich in antioxidants and omega-3 fatty acids, regular exercise, and stress management may help reduce non-cancerous elevations. Some studies suggest that hormonal fluctuations can influence CA125 levels, especially in reproductive conditions.‍Limiting exposure to hormone-disrupting chemicals in plastics, cosmetics, and certain foods can be beneficial for long-term hormone health. If you have a condition that affects CA125 levels, regular monitoring under the guidance of a healthcare provider can help track changes over time and manage any contributing conditions effectively.

What do high and low Cancer Antigen (CA125) levels mean?

Elevated CA125 levels can indicate ovarian cancer in those with known risk or a history of the disease, but they may also reflect benign conditions such as endometriosis, pelvic inflammatory disease, menstruation, or even normal variability. High levels in cancer patients often signify disease progression, recurrence, or a response to treatment.‍Normal or low CA125 levels are generally desirable and indicate that no significant inflammatory or malignant processes affecting CA125 are present. In cancer patients, low levels may suggest effective treatment or remission.