Best Supplements for Energy: 14 Picks Ranked by Evidence
The best vitamins for energy depend on the cause of your tiredness. Compare iron, B12, B complex, vitamin D, magnesium, CoQ10, rhodiola and creatine, and see which blood tests to check first.
- Published
- November 6, 2026
- Read time
- 16 min read
- Medically reviewed by
-
Rhonda Collins, FNP-C
Quick Summary
The best vitamins for energy are the ones that fix a shortfall you actually have. Iron, vitamin B12 and vitamin D have the clearest trial evidence for less tiredness, and that evidence comes from people whose levels were low to begin with [1][2]. A B complex and magnesium malate support the same energy pathways and suit people whose diet runs short on them. CoQ10, rhodiola and creatine have smaller or mixed trials behind them for fatigue. Because the right pick depends on the cause, the most useful first step is a blood test for ferritin, B12, vitamin D, thyroid function and a complete blood count.
Introduction
“Which supplement will actually give me more energy?”
Most “energy” products are built around caffeine, sugar or very high doses of B vitamins. None of these fixes the reason you are tired. Vitamins and minerals do not contain energy themselves: they are cofactors your cells need to turn food into usable energy, carry oxygen and keep nerves and muscles working [1]. When one of them runs low, fatigue is a common early sign. When your levels are already adequate, adding more rarely makes a noticeable difference.
That is why this guide is organized by cause rather than by product. Each section names the situation where a supplement has evidence behind it, what that evidence found, and which test tells you whether it applies to you.
What makes a good energy supplement:
- A form your body absorbs well (iron bisglycinate, methylcobalamin, vitamin D3, magnesium malate or citrate)
- A label dose that matches the studies, stated per serving rather than hidden in a blend
- Third-party testing or a GMP-certified facility
- No caffeine or stimulant blend passed off as “energy support”
What to avoid:
- Proprietary “energy blends” that do not list each ingredient’s amount
- Iron taken without a recent ferritin result
- Megadoses of single B vitamins with no deficiency to correct
- Products that promise a result in days
Which Supplement Fits Your Kind of Tiredness?
| Likely cause or need | Supplement | Notes |
|---|---|---|
| Low iron stores (heavy periods, plant-based diet, endurance) | Iron | Evidence for less fatigue when ferritin is low, even without anemia; test first |
| Low B12 (vegan diet, over 50, metformin, acid reducers) | Vitamin B12 | Deficiency causes tiredness and anemia; methylcobalamin and cyanocobalamin both work |
| Diet short on several B vitamins | B complex | Covers all eight B vitamins involved in energy metabolism |
| Low vitamin D (little sun, darker skin, winter) | Vitamin D3 | One trial in deficient adults found less fatigue after a single dose |
| Muscle fatigue, low magnesium intake | Magnesium malate | About half of US adults get less magnesium from food than they need |
| Fatigue with ongoing stress | Rhodiola | Small trials, mixed quality; some show less mental fatigue |
| Statin users, adults over 50 | CoQ10 | Meta-analysis of 13 trials found modestly lower fatigue scores; statins lower CoQ10 levels |
| Mental fatigue, training load | Creatine | Strong evidence for high-intensity exercise; smaller evidence for mental fatigue |
Top picks
Best for Tiredness From Low Iron Stores: Iron Bisglycinate
-
Best for low ferritin confirmed on a blood test, sensitive stomach
Jump to review -
Klaire Labs/SFI Health Iron Chelate
Best for vegan iron with a longer-lasting bottle
Jump to review
Best for Low B12: Vitamin B12 (Methylcobalamin)
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Jarrow Formulas Methyl B-12 1000mcg Lemon
Best for vegans, adults over 50, long-term metformin or acid-reducer use
Jump to review -
Life Extension Vitamin B12 - Methylcobalamin 1mg Lozenges
Best for dissolvable lozenge in a smaller bottle
Jump to review
Best for Broad B-Vitamin Support: B Complex
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Integrative Therapeutics Active B-Complex
Best for higher-dose complex with methylfolate and methylcobalamin
Jump to review -
Nordic Naturals Vitamin B Complex
Best for one capsule a day with coenzyme forms
Jump to review
Best for Low Vitamin D: Vitamin D3
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Pure Encapsulations Vitamin D3 25mcg (1,000IU)
Best for hypoallergenic, low per-capsule dose that is easy to adjust
Jump to review
Best for Muscle Fatigue and Low Magnesium Intake: Magnesium Malate
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NOW Foods Magnesium Malate 1000mg
Best for magnesium malate with the most tablets per bottle
Jump to review -
Best for citrate and malate blend in a small capsule
Jump to review
Best for Fatigue With Stress: Rhodiola
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Pure Encapsulations Rhodiola Rosea
Best for extract standardized to rosavins and salidroside
Jump to review -
Gaia Herbs Pro Rhodiola Phyto-Caps
Best for liquid-filled capsule with stated rosavin content
Jump to review
Best for Statin Users and Adults Over 50: CoQ10
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Integrative Therapeutics CoQ10 100mg
Best for practitioner-brand ubiquinone softgel
Jump to review -
Best for soy-free softgel in two bottle sizes
Jump to review
Best for Mental Fatigue and Training: Creatine Monohydrate
-
Best for unflavored creatine monohydrate with no other ingredients
Jump to review
Reviews
Each card shows the current price from the Mito catalog.
Best for Tiredness From Low Iron Stores: Iron Bisglycinate
Iron carries oxygen in red blood cells and runs energy-producing enzymes in every cell [1]. Low iron stores can cause fatigue before they cause anemia [3]. In a randomized trial of 198 menstruating women with unexplained fatigue, ferritin below 50 µg/L and normal hemoglobin, 12 weeks of oral iron lowered fatigue scores by 47.7%, against 28.8% with placebo [2]. That benefit applies to people with low stores. Do not take iron without a confirmed low ferritin or iron result: the trial showed a benefit in people with low stores, and a blood test is how you know you are one of them.
Best for Low ferritin confirmed on a blood test, sensitive stomach
1. Thorne Iron Bisglycinate
- Form: Ferrous bisglycinate chelate (Ferrochel)
- Iron per Capsule: 25 mg
- Label Serving: 1 capsule
- Third-Party Testing: NSF version of Thorne Iron Bisglycinate
- Bottle: 60 capsules (60 servings)
- Best For: Low ferritin confirmed on a blood test, sensitive stomach
Iron is essential to the formation and function of healthy red blood cells.
Pros
- Chelated form marketed as gentler on the stomach than ferrous sulfate
- Short ingredient list
- Moderate per-capsule dose
Cons
- Contains no vitamin C, which some people pair with iron to aid absorption
Best for Vegan iron with a longer-lasting bottle
2. Klaire Labs Iron Chelate
- Form: Ferrous bisglycinate chelate (Albion Ferrochel)
- Iron per Capsule: 30 mg
- Label Serving: 1 capsule with food
- Bottle: 100 capsules (100 servings)
- Best For: Vegan iron with a longer-lasting bottle
This compound has been shown to be a well-tolerated, bioavailable form of iron.
Pros
- Vegan and made without common allergens
- 100 capsules per bottle
- Same chelated iron form as the Thorne pick
Cons
- Label says it is not intended for children
For a deeper look at iron forms, see the best iron supplement for anemia.
Best for Low B12: Vitamin B12 (Methylcobalamin)
Vitamin B12 is needed to make red blood cells and to keep nerves working, and a shortfall can cause fatigue and anemia [1]. Deficiency is more likely in vegans and strict vegetarians, older adults, people who have taken metformin for more than four months, and people who have taken proton pump inhibitors or H2 blockers for more than a year [4]. In a study of more than 25,000 people with B12 deficiency, two or more years of proton pump inhibitor use was linked with 65% higher odds of deficiency [5]. A clinical review reports that oral B12 at 1 to 2 mg a day is as effective as injections for correcting anemia and nerve symptoms [4]. If your B12 is already normal, extra B12 is unlikely to raise your energy.
Best for Vegans, adults over 50, long-term metformin or acid-reducer use
1. Jarrow Formulas Methyl B-12 1000 mcg
- Form: Methylcobalamin, lemon chewable
- B12 per Tablet: 1,000 mcg
- Label Serving: 1 tablet, dissolved in the mouth or chewed
- Bottle: 100 chewables (100 servings)
- Best For: Vegans, adults over 50, long-term metformin or acid-reducer use
Methylcobalamin (Methyl B-12) is better absorbed and retained than other forms of B12 (e.g., cyanocobalamin).
Pros
- Dose in the range a clinical review reports for oral repletion
- Free of wheat, gluten, soy and dairy
- More than three months per bottle
Cons
- Sweetened with xylitol
- Lemon flavor only
Best for Dissolvable lozenge in a smaller bottle
2. Life Extension Vitamin B12 Methylcobalamin 1 mg Lozenges
- Form: Methylcobalamin, vanilla lozenge
- B12 per Lozenge: 1 mg (1,000 mcg)
- Label Serving: 1 lozenge
- Bottle: 60 lozenges (60 servings)
- Best For: Dissolvable lozenge in a smaller bottle
Vitamin B12, also called cobalamin, is a water-soluble vitamin.
Pros
- Dissolves in the mouth, no swallowing
- Vegetarian and non-GMO
Cons
- Contains sorbitol and xylitol
- Smaller bottle than the Jarrow pick
Best for Broad B-Vitamin Support: B Complex
The eight B vitamins work together as coenzymes in energy production, and low levels of one or more of them are common in developed countries [1][6]. A B complex is a reasonable choice when your diet is limited, for example when you avoid whole grains, meat or dairy, rather than when a single deficiency has been found. If a test shows low B12 specifically, a dedicated B12 product gives a higher dose of that one vitamin.
Best for Higher-dose complex with methylfolate and methylcobalamin
1. Integrative Therapeutics Active B-Complex
- Form: All 8 B vitamins, with methylfolate (Quatrefolic), methylcobalamin and P5P
- Key Amounts: 1,000 mcg B12, 50 mg B6, 800 mcg DFE folate per 2 capsules
- Label Serving: 2 capsules
- Bottle: 60 capsules (30 servings) or 120 capsules (60 servings)
- Best For: Higher-dose complex with methylfolate and methylcobalamin
Active B-Complex is a potent blend containing all 8 B-vitamins, including the active forms of vitamins B2, B6, and B12, as well as Quatrefolic-branded methylfolate (the bioactive form of folate).
Pros
- Active coenzyme forms of B2, B6, folate and B12
- Includes choline and inositol
- No gluten, soy, dairy or artificial colors
Cons
- Two-capsule serving
- Higher B6 (50 mg) per serving than the Nordic Naturals pick
Best for One capsule a day with coenzyme forms
2. Nordic Naturals Vitamin B Complex
- Form: Eight B vitamins in coenzyme forms (5-MTHF, methylcobalamin, P5P, R5P)
- Key Amounts: 250 mcg B12, 45 mg B6, 333 mcg DFE folate per capsule
- Label Serving: 1 capsule with food
- Bottle: 45 capsules (45 servings)
- Best For: One capsule a day with coenzyme forms
Delivering physiologically meaningful doses of eight highly absorbable and water-soluble B vitamins, Nordic Naturals Vitamin B Complex supports daily cellular operations and helps optimize important metabolic activities throughout the body.
Pros
- One capsule per serving
- Coenzyme forms throughout
- No gluten, milk derivatives, wheat or soy
Cons
- Lower B12 per capsule than the Integrative Therapeutics pick
- Smaller bottle
Best for Low Vitamin D: Vitamin D3
Low vitamin D has been associated with fatigue, and one placebo-controlled trial tested whether correcting it helps [7]. In 120 otherwise healthy adults with fatigue and vitamin D below 20 ng/mL, a single 100,000 IU dose of vitamin D3 improved fatigue scores at four weeks more than placebo, and 72% of the vitamin D group reported less fatigue, against 50% on placebo [7]. That result applies to people who started out deficient. A vitamin D test tells you whether you are one of them.
Best for Hypoallergenic, low per-capsule dose that is easy to adjust
1. Pure Encapsulations Vitamin D3 1,000 IU
- Form: Cholecalciferol (vitamin D3)
- Vitamin D per Capsule: 25 mcg (1,000 IU)
- Label Serving: 1 capsule with food
- Bottle: 60, 120 or 250 capsules (1 capsule per serving)
- Best For: Hypoallergenic, low per-capsule dose that is easy to adjust
Vitamin D3 naturally supports calcium absorption and retention within bones to promote optimal bone health.
Pros
- Hypoallergenic and vegetarian
- Low per-capsule dose that fits retesting and adjustment
- Three bottle sizes
Cons
- Label advises monitoring blood levels for people taking more than 2,000 IU a day
Best for Muscle Fatigue and Low Magnesium Intake: Magnesium Malate
Magnesium is involved in producing ATP, the molecule cells use for energy, and in muscle contraction [1]. Almost half of the US population got less magnesium from food than required in 2005 to 2006 national survey data [8]. Malate is itself part of the cycle cells use to make energy, which is why magnesium malate is the form most often marketed for fatigue. Trials comparing magnesium forms for energy are small, so choose this when your diet is low in magnesium rather than expecting a stimulant effect. For more on this form, see magnesium malate for energy.
Best for Magnesium malate with the most tablets per bottle
1. NOW Foods Magnesium Malate 1000 mg
- Form: Magnesium malate
- Elemental Magnesium: 113 mg per tablet (from 1,000 mg magnesium malate)
- Label Serving: 1 tablet, up to three times daily with food
- Third-Party Testing: Made in a GMP facility
- Bottle: 180 tablets
- Best For: Magnesium malate with the most tablets per bottle
Magnesium is a mineral that is critical for energy production and metabolism, muscle contraction, nerve impulse transmission and bone mineralization.
Pros
- Elemental magnesium printed on the label
- 180 tablets per bottle
Cons
- Large tablets
- Carries a California Proposition 65 lead warning
Best for Citrate and malate blend in a small capsule
2. Thorne Magnesium CitraMate
- Form: Magnesium citrate and dimagnesium malate
- Elemental Magnesium: 135 mg per capsule (55 mg as citrate, 80 mg as malate)
- Label Serving: 1 capsule, one to three times daily
- Bottle: 90 capsules
- Best For: Citrate and malate blend in a small capsule
Magnesium is essential for the health of the heart and blood vessels, brain, bones, muscles, and lungs.
Pros
- Two well-absorbed forms in one capsule
- Only two other ingredients
Cons
- Citrate can loosen stools at higher amounts
- Smaller bottle than the NOW pick
Best for Fatigue With Stress: Rhodiola
Rhodiola rosea is an herb studied for stress-related fatigue, and the results are mixed. In a four-week randomized trial of 60 adults with stress-related fatigue, a standardized rhodiola extract (576 mg a day) improved burnout scores and attention more than placebo [9]. An open-label trial of 100 adults with prolonged fatigue reported falling fatigue scores over eight weeks on 400 mg a day, but it had no placebo group [10]. A systematic review of 11 trials found the evidence contradictory and the studies at high or unclear risk of bias [11]. Treat rhodiola as a possible help for stress-linked tiredness, not a proven one.
Best for Extract standardized to rosavins and salidroside
1. Pure Encapsulations Rhodiola Rosea
- Form: Rhodiola rosea root extract, standardized to 3% rosavins and 1% salidrosides
- Extract per Capsule: 100 mg
- Label Serving: 1 to 2 capsules a day between meals
- Bottle: 90 or 180 capsules
- Best For: Extract standardized to rosavins and salidroside
Rhodiola Rosea helps lessen mental and physical stress as well as promote endurance.
Pros
- Standardized to both rosavins and salidroside
- Hypoallergenic and vegan
Cons
- Lower extract per capsule than the doses used in trials
- Label notes it may be contraindicated with adrenergic-blocking and antiarrhythmic medications
Best for Liquid-filled capsule with stated rosavin content
2. Gaia Herbs Rhodiola Phyto-Caps
- Form: Siberian rhodiola root extract, liquid phyto-cap
- Extract per Capsule: 120 mg, with 6 mg rosavins
- Label Serving: 1 capsule twice daily between meals
- Bottle: 60 capsules
- Best For: Liquid-filled capsule with stated rosavin content
Rhodiola is a potent herb that is thought to help the body adapt to stress in a healthy way.
Pros
- Rosavin amount stated per capsule
- Vegetarian capsule
Cons
- Smaller bottle than the Pure Encapsulations pick
- Label advises against use during pregnancy or nursing without a provider
Best for Statin Users and Adults Over 50: CoQ10
CoQ10 is part of the chain of reactions mitochondria use to make energy. A 2022 meta-analysis of 13 randomized trials with 1,126 participants found that CoQ10 lowered fatigue scores modestly compared with placebo, with larger effects at higher daily doses and longer use [12]. Statins lower blood CoQ10 levels, according to a meta-analysis of placebo-controlled trials [13]. Whether CoQ10 helps the muscle symptoms some statin users report is mixed: a 2018 meta-analysis of 12 trials found less muscle pain, weakness and tiredness, while an earlier 2015 meta-analysis found no significant effect [14][15]. If you take a statin and notice muscle symptoms, talk with your prescribing clinician before changing anything.
Best for Practitioner-brand ubiquinone softgel
1. Integrative Therapeutics CoQ10 100 mg
- Form: Ubiquinone (trans-CoQ10 from yeast fermentation) in soybean oil
- CoQ10 per Softgel: 100 mg
- Label Serving: 1 softgel, up to three times daily
- Bottle: 60 softgels
- Best For: Practitioner-brand ubiquinone softgel
Provides 100 mg coenzyme Q10 for cardiovascular, neurological, and immune system health.
Pros
- Oil-based softgel, which suits a fat-soluble nutrient
- Easy-to-swallow softgel
Cons
- Contains soy
- Label warns against use in pregnancy
Best for Soy-free softgel in two bottle sizes
2. NOW Foods CoQ10 100 mg Softgels
- Form: CoQ10 in olive oil and sunflower lecithin
- CoQ10 per Softgel: 100 mg
- Label Serving: 1 softgel, one to two times daily with food
- Bottle: 50 or 150 softgels
- Best For: Soy-free softgel in two bottle sizes
Coenzyme Q10 (CoQ10) is a vitamin-like compound that plays a central role in cellular energy production.
Pros
- Available in a 150-softgel bottle
- Soy-free
- Made in a GMP facility
Cons
- Bovine gelatin softgel, so not vegetarian
Best for Mental Fatigue and Training: Creatine Monohydrate
Creatine is best known for high-intensity exercise. Supplementation raises muscle creatine stores and improves performance in short, hard efforts, according to the International Society of Sports Nutrition [16]. Evidence for mental fatigue is smaller. In a double-blind trial, 8 g a day for five days reduced mental fatigue during repeated arithmetic tasks [17]. A systematic review of six trials in healthy people found possible gains in short-term memory and reasoning, but conflicting results for mental fatigue [18]. For more, see creatine beyond the gym.
Best for Unflavored creatine monohydrate with no other ingredients
1. Klean Athlete Klean Creatine
- Form: Creatine monohydrate powder, unflavored
- Creatine per Scoop: 5 g
- Label Serving: 1 scoop mixed with 8 oz of water or another drink
- Bottle: 315 g (63 scoops)
- Best For: Unflavored creatine monohydrate with no other ingredients
If your sport requires you to go 'all out' for short bursts, creatine can help you reach your strength and power objectives.
Pros
- Creatine monohydrate is the most studied form
- No other ingredients
- Vegan and gluten-free
Cons
- Powder only
- Unflavored, so it needs mixing into a drink
What to Look For in an Energy Supplement
1. A Test Result That Points to It
The strongest fatigue evidence for iron, B12 and vitamin D comes from people who were low [2][7]. Matching the supplement to a measured shortfall is the most reliable way to feel a difference, and it keeps you from taking iron you do not need.
2. The Form on the Label
- Iron: the fatigue trial above used ferrous sulfate; bisglycinate is a chelated form marketed as gentler on the stomach.
- B12: methylcobalamin and cyanocobalamin both raise B12 levels.
- Vitamin D: D3 (cholecalciferol) is the form in the trial above.
- Magnesium: malate, citrate and glycinate absorb better than oxide.
- CoQ10: ubiquinone in an oil-based softgel is the form in most products and trials.
3. The Dose per Serving
Compare the amount of the active ingredient per serving, not the bottle size. For magnesium, look for the elemental amount. For rhodiola, look for the standardized extract and its rosavin or salidroside content. For B12, 1,000 mcg is the amount most products use.
4. Quality Signals
Look for third-party certification such as NSF or USP, or at minimum manufacturing in a GMP-certified facility. For what each seal does and does not verify, see how to choose a supplement brand.
5. No Stimulant Blend
Products sold as “energy” formulas often add caffeine, green tea extract or guarana. These change how alert you feel for a few hours and say nothing about why you are tired. Check the full ingredient list before buying.
Cost Comparison
Each product card above shows its current price from the Mito catalog. To compare cost per serving, divide that price by the servings per bottle below. Some labels allow more than one serving a day (magnesium, rhodiola and CoQ10), so a bottle of those lasts fewer days at the higher amount.
| Product | Bottle sizes | Label serving | Servings per bottle |
|---|---|---|---|
| Thorne Iron Bisglycinate | 60 capsules | 1 capsule | 60 |
| Klaire Labs Iron Chelate | 100 capsules | 1 capsule | 100 |
| Jarrow Formulas Methyl B-12 1000 mcg | 100 chewables | 1 tablet | 100 |
| Life Extension B12 Methylcobalamin 1 mg | 60 lozenges | 1 lozenge | 60 |
| Integrative Therapeutics Active B-Complex | 60 or 120 capsules | 2 capsules | 30 or 60 |
| Nordic Naturals Vitamin B Complex | 45 capsules | 1 capsule | 45 |
| Pure Encapsulations Vitamin D3 1,000 IU | 60, 120 or 250 capsules | 1 capsule | 60, 120 or 250 |
| NOW Foods Magnesium Malate 1000 mg | 180 tablets | 1 tablet | 180 |
| Thorne Magnesium CitraMate | 90 capsules | 1 capsule | 90 |
| Pure Encapsulations Rhodiola Rosea | 90 or 180 capsules | 1 capsule | 90 or 180 |
| Gaia Herbs Rhodiola Phyto-Caps | 60 capsules | 1 capsule | 60 |
| Integrative Therapeutics CoQ10 100 mg | 60 softgels | 1 softgel | 60 |
| NOW Foods CoQ10 100 mg | 50 or 150 softgels | 1 softgel | 50 or 150 |
| Klean Athlete Klean Creatine | 315 g | 1 scoop (5 g) | 63 |
Test This with Mito
Fatigue has many possible causes, and several of them show up on a routine blood test. Testing first tells you which of the supplements above applies, and retesting tells you whether it worked.
- Ferritin: your iron stores. The trial above enrolled women with ferritin below 50 µg/L [2].
- Iron and TIBC panel: circulating iron and how much iron your blood can carry, alongside ferritin.
- Vitamin B12 and folate panel: the two B vitamins most often linked to tiredness and anemia.
- Vitamin D, 25-hydroxy: the standard measure of your vitamin D status.
- Thyroid-stimulating hormone (TSH): an underactive thyroid is a common cause of fatigue that no supplement here addresses.
- Complete blood count (CBC): checks for anemia and red blood cell size, which can point toward iron or B12.
- Mito Core Panel: includes all of the tests above (ferritin, iron and TIBC, vitamin B12, folate, vitamin D, TSH and CBC) plus free T4, free T3, RBC magnesium, cortisol, HbA1c and a comprehensive metabolic panel, with clinician-reviewed results.
To compare energy-related tests side by side, browse energy, mood and sleep lab tests. For a walk-through of which results explain tiredness, read Always Tired? The Blood Tests That Explain Fatigue.
Key Takeaways
- Test before you supplement: iron, B12 and vitamin D help tiredness mainly when levels are low.
- Never guess on iron: take it only after a low ferritin or iron result.
- B12 matters most for at-risk groups: vegans, adults over 50, and long-term metformin or acid-reducer users.
- A B complex suits a limited diet, not a single confirmed deficiency.
- Magnesium malate suits a diet short on magnesium, not a search for a stimulant effect.
- CoQ10, rhodiola and creatine have smaller or mixed evidence for fatigue.
- Skip stimulant “energy blends” that hide doses or rely on caffeine.
Frequently asked questions
What vitamins are best for fatigue and tiredness?
Iron, vitamin B12 and vitamin D have the clearest trial evidence for less fatigue, and in each case the benefit was seen in people whose levels were low [2][7]. The other B vitamins and magnesium support energy metabolism too and matter when your diet falls short [1]. Without a shortfall, none of them works like a stimulant.
What vitamins am I lacking if I’m always tired?
The most common nutrient causes of tiredness are low iron stores, low vitamin B12 and low vitamin D. Folate and magnesium are less common causes. You cannot tell these apart by how you feel, so a blood test for ferritin, B12 and folate, vitamin D and a complete blood count is the reliable way to find out. An underactive thyroid causes similar tiredness, which is why TSH belongs on the same test.
Is B6 or B12 better for energy?
For most people, B12. B12 deficiency is common in specific groups and causes tiredness and anemia [4]. B6 deficiency is uncommon in people who eat a varied diet. Both are part of a B complex. If a test shows low B12, a dedicated B12 supplement gives a higher dose of it.
Do energy supplements work if my levels are normal?
Usually not in a way you would notice. The trials behind iron, B12 and vitamin D enrolled people who were low or at risk. CoQ10 has modest evidence across mixed groups, and rhodiola and creatine have small trials with mixed results [12][11][18].
How long do energy supplements take to work?
It depends on the supplement and how low you started. In the iron trial, fatigue was measured after 12 weeks [2]. In the vitamin D trial, it was measured four weeks after a single dose [7]. Retesting the marker you are correcting tells you whether your levels have actually moved.
Are B12 shots better than B12 pills?
Not usually. A clinical review found that oral B12 at 1 to 2 mg a day is as effective as injections for correcting anemia and nerve symptoms. Injections work faster and are considered for severe deficiency or severe nerve symptoms [4].
Related Content
- Best Magnesium Supplements: Brands Ranked by Quality
- Magnesium Malate for Energy
- Best Iron Supplement for Anemia
- Always Tired? Blood Tests for Fatigue
- Vitamin B12 and Energy After 30
- Creatine: The Overlooked Supplement for Body and Mind
- Science-Based Pre-Workout Supplements Guide
- Energy, Mood and Sleep Lab Tests
Medical Disclaimer
This article is for educational purposes only and is not medical advice. It does not diagnose or treat any condition. Persistent or unexplained fatigue can have causes beyond nutrition, so discuss it with your doctor, especially if you are pregnant, take prescription medications or have a chronic condition.
References
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- Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. 2009;75(2):105-12. PMID: 19016404
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- Ishaque S, Shamseer L, Bukutu C, Vohra S. Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med. 2012;12:70. PMC3541197
- Tsai IC, Hsu CW, Chang CH, Tseng PT, Chang KV. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2022;13:883251. PMC9449413
- Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations: A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329-36. PMID: 26192349
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