Vitamin B12 (Cobalamin) and Folate Panel
Two B vitamins behind anemia, fatigue, and nerve symptoms, measured together.
Consider this test if:
- Fatigue, brain fog, poor concentration, or numbness and tingling with no clear cause
- Anemia found on a blood count, especially with large red cells
- Following a vegetarian or vegan diet, or heavy alcohol use
- Taking metformin or long-term acid-suppressing medication that lowers B12 absorption
- Pregnant, planning pregnancy, or confirming that B12 or folate supplements are restoring your levels
- HSA/FSA eligible
- Typical results in 1-2 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required. If you take B12 or folate supplements, or recently had a B12 injection, note the dose and timing, since both raise serum levels and can mask a deficiency. For the truest baseline, some prefer to test before starting supplementation.
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What this test is for
This panel measures vitamin B12 (cobalamin) and folate, two B vitamins the body needs to make red blood cells, build DNA, and keep nerves working. Low levels cause megaloblastic anemia and can contribute to fatigue, weakness, brain fog, poor concentration, numbness or tingling, and reduced exercise tolerance. B12 drops with pernicious anemia, gastrectomy, malabsorption, and long-term metformin or acid-suppressing medication, while folate falls with poor diet, alcohol use, pregnancy, and small-bowel damage. The two are tested together because they overlap clinically and a B12 deficiency can lower folate uptake, so checking one without the other can mislead. Measuring both at once tells you which vitamin is actually short before you start replacing anything.
Biomarkers tested
Includes 2 biomarkers
Folate fuels the one-carbon reactions that build DNA and recycle homocysteine, work that shows up fastest in cells that divide quickly, like red blood cells. Low folate produces the same picture as B12 deficiency: fatigue, weakness, poor concentration, irritability, and large, immature red blood cells (macrocytic anemia), so the two are usually tested together to sort out which one is driving symptoms. It's also relevant during preconception and pregnancy planning, since adequate folate is what prevents neural tube defects, and worth checking if you drink heavily, follow a restrictive diet, or take medications that interfere with folate metabolism.
- Specimen
- Serum or plasma
- Measures
- Mass concentration
B12 lets your cells build DNA and lets nerves maintain the myelin sheath that insulates them, so levels here reveal whether your body has what it needs to make red blood cells and keep nerve signals firing cleanly. Low B12 shows up as fatigue, poor concentration, numbness or tingling, weakness, and reduced exercise tolerance, and it's common in vegetarians, vegans, people on metformin or acid-reducing medications, and those with absorption issues like low stomach acid or gut disease. Testing it establishes a baseline if you're plant-based or on these medications, and clarifies whether B12 deficiency, not just poor sleep or overtraining, is behind the fog and fatigue.
- Specimen
- Serum or plasma
- Measures
- Mass concentration
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 1-2 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
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Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost — covering the lab and what it takes to run the service — never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9/mo, and you still pay the lab’s order fee. Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results post to your dashboard once your lab completes them, then a clinician reviews them and your full analysis and personalized action plan (with clear next steps) follow. Turnaround varies by test: specialty assays and at-home kits take longer, and each test shows its expected turnaround before you buy.
Do I need a doctor’s order?
No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.
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