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Best Gut Health Supplements in 2026: What Works for Bloating, IBS and Regularity

Gut health supplements ranked by evidence, from psyllium and peppermint oil to strain-specific probiotics, Saccharomyces boulardii and digestive enzymes, with picks for each gut concern.

Published
November 6, 2026
Read time
15 min read
Medically reviewed by
Rhonda Collins Rhonda Collins, FNP-C

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Quick Summary

The gut health supplements with the best evidence depend on the problem. For constipation, psyllium and other soluble fibers have the strongest trial record. For IBS pain and bloating, the American College of Gastroenterology recommends soluble fiber and suggests peppermint oil [1]. For diarrhea during antibiotics, Saccharomyces boulardii lowered how often it happened in trials [2]. Probiotics for IBS and for everyday “gut health” in healthy adults have weak evidence, and the American Gastroenterological Association recommends IBS probiotics only within clinical trials [3].

Introduction

“Which gut health supplement actually works?”

The problem: gut health supplements are one of the largest aisles in the supplement store, and most products promise to “balance your microbiome.” Yet in randomized trials in healthy adults, probiotics did not consistently change the overall makeup of the gut bacteria compared with placebo [4]. Benefits show up for specific problems, with specific ingredients and, for probiotics, specific strains.

Why it matters: constipation, bloating and IBS are common and long-lasting, so a product you choose may become a daily habit. Fiber is one of the few supplements with a place in gastroenterology guidelines: a joint AGA and ACG guideline suggests fiber supplements for chronic constipation [5].

How this guide picks:

  • Evidence first: each ingredient is graded by what randomized trials, systematic reviews and gastroenterology guidelines found, not by the label’s claims.
  • Grouped by gut concern: constipation, IBS pain and bloating, diarrhea with antibiotics, gas after meals and everyday support each have different best options.
  • Catalog products only: every pick is a named product in Mito’s supplement catalog that was in stock when this guide was written.
  • Mixed brands: no brand has more than two picks.

What this guide leaves out: L-glutamine, collagen and bone broth products sold for “leaky gut,” and multi-step cleanses, because they lack trial evidence for common gut symptoms in adults.

Which gut health supplement fits your concern?

The table maps each common gut concern to the ingredient with the best evidence, and says plainly how strong that evidence is.

Gut concernIngredient with the best evidenceHow strong the evidence is
ConstipationPsyllium (soluble fiber)Moderate: a meta-analysis of 16 trials, with psyllium among the fibers that helped [6]
IBS symptomsSoluble fiber, such as psyllium or PHGGModerate: helped in a meta-analysis of 14 trials, while bran did not [7][8]
IBS pain and overall symptomsEnteric-coated peppermint oilLow: beat placebo in 10 trials, but the quality of evidence was rated very low [9]
IBS symptomsStrain-specific probioticsLow to very low: some strains helped, but results vary by strain and trial [10]
Diarrhea during antibioticsSaccharomyces boulardiiModerate: a meta-analysis of 21 trials found fewer cases with S. boulardii [2]
Everyday gut and microbiome healthProbiotics or prebioticsWeak: no consistent effect on gut bacteria in healthy adults [4]; prebiotics raise bifidobacteria [11]
Gas after mealsDigestive enzymes (alpha-galactosidase, lactase)Limited: small, older trials for specific foods [12][13]

Top picks

Best for Constipation and Regularity: Soluble Fiber

Best for IBS Pain and Bloating: Enteric-Coated Peppermint Oil

Best for IBS Symptoms (Weaker Evidence): Strain-Specific Probiotics

Best for Diarrhea During Antibiotics: Saccharomyces boulardii

Best for Gas After Meals (Weaker Evidence): Digestive Enzymes

Best for Everyday Gut Support (Weakest Evidence): Probiotics and Prebiotics

Reviews

Best for Constipation and Regularity: Soluble Fiber

Fiber is the gut supplement with the clearest evidence. In a meta-analysis of 16 randomized trials in 1,251 adults with chronic constipation, 66% responded to fiber compared with 41% on control treatments. Psyllium and pectin had significant effects, and the benefit was clearest at more than 10 g of fiber a day taken for at least four weeks [6]. For IBS, soluble fiber helped in a meta-analysis of 14 trials while bran did not [7], and the ACG recommends soluble fiber for overall IBS symptoms [1]. Fiber can increase gas at first, which is why it is usually added gradually with plenty of fluid [6].

Best for plain psyllium, the fiber with the most trial support for constipation

1. NOW Foods Psyllium Husk Powder

  • Form: Unflavored powder
  • Key Ingredient: Psyllium seed husk, 7 g fiber (6 g soluble) per tablespoon
  • Label Serving: 1 level tablespoon in at least 12 oz of liquid
  • Sizes: 340 g or 680 g
  • Best For: plain psyllium, the fiber with the most trial support for constipation
View product

Excellent source of fiber.

Pros

  • Single ingredient with no sweeteners or flavors
  • Psyllium is the fiber type with the most consistent constipation data
  • Lowest list price in this guide

Cons

  • Thickens quickly, so it has to be drunk right away
  • Can cause gas and bloating until you adjust

Best for a partially hydrolyzed guar gum blend if psyllium leaves you bloated

2. Thorne FiberMend

  • Form: Unflavored powder
  • Key Ingredients: Partially hydrolyzed guar gum 8 g, rice bran, larch arabinogalactan, apple pectin and green tea phytosome per scoop
  • Fiber: 7 g (6 g soluble) per scoop
  • Label Serving: 1 scoop in 8 to 10 oz of liquid
  • Best For: a partially hydrolyzed guar gum blend if psyllium leaves you bloated
View product

The well-tolerated prebiotic fiber formula in FiberMend stimulates the growth of beneficial bacteria in the GI tract that support a healthy digestive system and balanced GI microbiota.

Pros

  • Mixes easily and has no taste or smell
  • Built around partially hydrolyzed guar gum (PHGG), studied in IBS
  • No sweeteners

Cons

  • Several ingredients, so the blend as a whole is untested
  • Costs more per serving than plain psyllium

In a 12-week trial in 121 people with IBS, 6 g a day of PHGG improved bloating scores compared with placebo, though not overall IBS severity or quality of life [8].

Best for IBS Pain and Bloating: Enteric-Coated Peppermint Oil

Peppermint oil relaxes the smooth muscle of the gut. In a meta-analysis of 10 randomized trials in 1,030 people with IBS, peppermint oil beat placebo for overall symptoms and abdominal pain, but side effects were more common and the quality of evidence was rated very low [9]. The ACG suggests peppermint oil for overall IBS symptoms on low-quality evidence [1]. Enteric coating lets the oil pass the stomach before it is released, which matters because peppermint can bring on heartburn.

Best for enteric-coated peppermint oil softgels at a budget price

1. NOW Foods Peppermint Gels

  • Form: Enteric-coated softgel
  • Key Ingredients: Peppermint oil 362 mg, ginger oil 35.2 mg and fennel oil 38.6 mg per 2 softgels
  • Label Serving: 1 to 2 softgels before meals
  • Servings per Container: 90 softgels
  • Best For: enteric-coated peppermint oil softgels at a budget price
View product

Peppermint Oil has been recommended for centuries by traditional herbalists for the support of healthy digestion.

Pros

  • Enteric coated, so the oil is released past the stomach
  • Amount of each oil stated on the label
  • Low list price

Cons

  • Adds ginger and fennel oils, so the exact formula is untested
  • Contains gelatin and soybean oil
  • The label advises against use during pregnancy or nursing

IBS Symptoms (Weaker Evidence): Strain-Specific Probiotics

Probiotic results in IBS depend on the exact strain, which is why a generic “probiotic” says little. A 2023 meta-analysis of 82 trials found that some strains and combinations may help, but rated the certainty of the evidence low to very low across almost all analyses [10]. The AGA recommends using probiotics for IBS only in the context of a clinical trial [3], and the ACG suggests against probiotics for overall IBS symptoms [1]. If you want to try one, choose a product built on a strain that has been tested in IBS and give it about four weeks.

Best for the L. plantarum 299v strain studied in IBS trials

1. Vital Nutrients Hyperbiotics IBS Support Probiotic

  • Form: Acid-resistant capsule
  • Key Ingredients: Lactiplantibacillus plantarum 299v, 30 billion CFU, and Boswellia serrata extract 125 mg per capsule
  • Label Serving: 1 capsule
  • Servings per Container: 30
  • Best For: the L. plantarum 299v strain studied in IBS trials
View product

Stabilize gut function and get accelerated and prolonged relief from occasional IBS symptoms, including abdominal pain, bloating, gas, and irregularity, with Hyperbiotics IBS Support Probiotic (formerly PRO-IBS Support), which features a clinically studied, highly stable and patented probiotic strain, Lactiplantibacillus plantarum 299V® (LP299V®), combined with Boswellia serrata extract to improve absorption and utilization.

Pros

  • Names the exact strain on the label
  • One capsule a day
  • Free of common allergens

Cons

  • Trials of the strain conflict: one found less pain and bloating, another found no difference
  • Adds boswellia, so the product itself is untested

In a 4-week trial in 214 people with IBS, L. plantarum 299v reduced abdominal pain and bloating compared with placebo [14]. An 8-week trial found no difference from placebo, with a large placebo response in both groups [15].

Best for the two strains studied for bloating in functional bowel disorders

2. Metagenics UltraFlora IB Probiotic

  • Form: Vegetarian capsule
  • Key Ingredients: Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07, 60 billion CFU per capsule
  • Label Serving: 1 capsule, once or twice a day
  • Servings per Container: 30
  • Best For: the two strains studied for bloating in functional bowel disorders
View product

UltraFlora® IB is a clinically tested blend of “friendly” bacteria in a dairy free base.

Pros

  • Same two named strains as the bloating trial
  • Dairy-free, gluten-free and vegetarian

Cons

  • Highest list price in this guide
  • The trial used a higher daily amount than the label serving supplies

In an 8-week trial in 60 people with non-constipation functional bowel disorders, including IBS, the NCFM and Bi-07 combination improved bloating compared with placebo at 4 weeks [16].

Best for Diarrhea During Antibiotics: Saccharomyces boulardii

S. boulardii is a probiotic yeast, so antibiotics do not kill it. In a meta-analysis of 21 randomized trials, adults given S. boulardii during antibiotic treatment developed diarrhea less often: 8.2% compared with 17.4% without it [2]. The effect on C. difficile diarrhea in adults was not significant in that analysis [2]. The AGA suggests S. boulardii, among a few probiotics, for adults and children taking antibiotics with C. difficile infection as the concern, on low-quality evidence [3]. Trials tested specific strains, and neither pick below names its strain, so each carries the ingredient’s evidence rather than its own.

Best for S. boulardii that does not need refrigeration

1. Jarrow Formulas Saccharomyces Boulardii + MOS

  • Form: Vegetarian capsule
  • Key Ingredients: S. boulardii 5 billion CFU and mannan-oligosaccharides (MOS) 200 mg per capsule
  • Label Serving: 1 capsule, once or twice a day
  • Servings per Container: 90 or 180
  • Best For: S. boulardii that does not need refrigeration
View product

Saccharomyces Boulardii is a probiotic yeast clinically shown to benefit individuals in greater need for intestinal support, such as those who travel.

Pros

  • Shelf stable at room temperature
  • Two bottle sizes
  • Free of common allergens

Cons

  • Strain not named on the product page
  • Adds a prebiotic (MOS) that the S. boulardii trials did not test

Best for a single-ingredient S. boulardii from a practitioner brand

2. Klaire Labs Ther-Biotic Saccharomyces Boulardii

  • Form: Vegetarian capsule
  • Key Ingredient: S. boulardii, 3 billion CFU per capsule
  • Label Serving: 1 capsule twice a day
  • Servings per Container: 60 or 120 capsules
  • Best For: a single-ingredient S. boulardii from a practitioner brand
View product
Review with a clinician before buying

The label advises against use by people who are severely immunocompromised or have a central venous catheter, because yeast probiotics have rarely caused bloodstream infections in those groups.

Saccharomyces boulardii is a friendly probiotic yeast that augments the intestinal absorption of water and electrolytes during occasional diarrhea and increases stool concentrations of short-chain fatty acids that nourish GI mucosal cells.

Pros

  • No added prebiotic or other active ingredients
  • Made without common allergens, vegan

Cons

  • Strain not named on the product page
  • Lower CFU per capsule than the Jarrow pick

Gas After Meals (Weaker Evidence): Digestive Enzymes

Digestive enzymes help only when the problem matches the enzyme. Alpha-galactosidase breaks down the carbohydrates in beans and some vegetables: in a small crossover trial of 19 people eating a meatless chili, it reduced how often gas was passed over 6 hours, though not bloating or pain [12]. Lactase breaks down the milk sugar lactose. A systematic review found that most people with presumed lactose intolerance can tolerate 12 to 15 g of lactose, and concluded that more studies are needed to judge lactose intolerance treatments [13]. Broad “digest everything” blends have no trials of their own. Ongoing indigestion or upper abdominal pain has testable causes, covered under Test This with Mito below.

Best for a broad enzyme blend with lactase and alpha-galactosidase

1. Pure Encapsulations Digestive Enzymes Ultra

  • Form: Vegetarian capsule
  • Key Ingredients: Protease, amylase, lipase, lactase 1,600 ALU, alpha-galactosidase 120 GalU and fiber-digesting enzymes per 2 capsules
  • Label Serving: 1 to 2 capsules with each meal
  • Servings per Container: 90 or 180 capsules
  • Best For: a broad enzyme blend with lactase and alpha-galactosidase
View product

Digestive Enzymes Ultra contains an extensive profile of vegetarian digestive enzymes.

Pros

  • Includes the two enzymes with some trial support, lactase and alpha-galactosidase
  • Hypoallergenic, vegetarian ingredients

Cons

  • Lists enzyme activity units but not the weight of each enzyme
  • The blend as a whole is untested

Best for a one-capsule-per-meal enzyme blend

2. Enzymedica Digest Gold + Probiotics

  • Form: Vegetarian capsule
  • Key Ingredients: Enzyme blend 430 mg with alpha-galactosidase 450 GalU and lactase 900 ALU, plus 1 billion CFU of probiotics
  • Label Serving: 1 capsule with each meal
  • Servings per Container: 45, 90 or 180 capsules
  • Best For: a one-capsule-per-meal enzyme blend
View product

The enzymes in Digest Gold, America's #1 selling enzyme formula, break down all the parts of a typical large meal, like fat, fiber, protein and carbohydrates.

Pros

  • One capsule per meal
  • Three bottle sizes

Cons

  • Adds a probiotic blend, so the formula is harder to judge
  • Most of its probiotic strains are not named down to the strain

Everyday Gut Support (Weakest Evidence): Probiotics and Prebiotics

For a healthy adult with no symptoms, the evidence for a daily probiotic is thin. A systematic review of seven randomized trials in healthy adults found no effect of probiotics on the diversity of gut bacteria compared with placebo [4]. Prebiotics, the fibers that feed gut bacteria, do raise bifidobacteria, but a meta-analysis in people with IBS and other functional bowel disorders found no improvement in symptoms overall, and inulin-type prebiotics made gas worse [11]. Food is the cheaper route to the same fibers, and our guide to foods and supplements for gut health covers them. If you still want a supplement, choose a simple one.

Best for a simple four-strain daily probiotic

1. Nordic Naturals Nordic Probiotic Daily

  • Form: Vegetable capsule
  • Key Ingredients: Four strains, including L. acidophilus DDS-1, 12 billion CFU, with 20 mg FOS per 2 capsules
  • Label Serving: 2 capsules
  • Servings per Container: 30
  • Best For: a simple four-strain daily probiotic
View product

Nordic® Flora Probiotic Daily is Nordic Natural's original blend of four probiotic strains with 12 billion cultures for digestive wellness and immune support.

Pros

  • Short ingredient list
  • No gluten, milk derivatives or soy

Cons

  • Only one of the four strains is named down to the strain
  • No trial of this product

Best for a low-dose prebiotic powder without inulin

2. Pure Encapsulations Poly-Prebiotic Powder

  • Form: Powder
  • Key Ingredients: Xylooligosaccharide 1.4 g, alpha-glucooligosaccharide 1 g, and cranberry, blueberry and pomegranate extracts per scoop
  • Label Serving: 1 scoop, once or twice a day
  • Size: 138 g
  • Best For: a low-dose prebiotic powder without inulin
View product

A unique powdered blend of researched prebiotic fibers and polyphenols to support gastrointestinal, cellular, and immune function by boosting bifidobacteria and microbiome diversity.

Pros

  • Inulin-free, the prebiotic type most linked to extra gas
  • Low dose per scoop

Cons

  • Sweetened with stevia
  • About 30 scoops per container

What to look for in a gut health supplement

1. An Ingredient Matched to Your Gut Concern

Start from the symptom that bothers you most. Fiber for constipation, peppermint oil for IBS pain and S. boulardii during antibiotics each have trial support for that use, and little for the others.

2. The Exact Probiotic Strain

Probiotic effects belong to strains, not species. A label that lists “Lactobacillus plantarum 299v” can be matched to trials. A label that lists only “Lactobacillus plantarum” cannot [10].

3. Soluble Rather Than Insoluble Fiber for IBS

In IBS, soluble fibers such as psyllium helped and bran did not [7]. If wheat bran or other insoluble fibers make you feel worse, a soluble fiber is the better fit.

4. Fewer Ingredients

Gut formulas often stack probiotics, prebiotics, enzymes and herbs. When symptoms change, you cannot tell which ingredient helped, and inulin-type prebiotics can add gas [11].

5. Storage and Survival

Some probiotics need refrigeration to keep their live counts. Check whether the label guarantees the CFU count until the expiration date rather than at manufacture.

6. Who Should Check First

Probiotics are generally well tolerated in healthy people, but rare serious infections have been reported in people who are severely ill or immunocompromised [17].

Cost Comparison

Current prices show on each product card above, in the “From” line, and come live from Mito’s catalog. The price band below compares each product’s lowest list price in the catalog on November 6, 2026 with the other picks in this guide, from budget through mid to premium.

ProductFormSizes in catalogThird-party certificationPrice band
NOW Foods Psyllium Husk PowderPowder340 g or 680 gNot stated on product pageBudget
Thorne FiberMendPowder330 gNot stated on product pageMid
NOW Foods Peppermint GelsSoftgel90 softgelsNot stated on product pageBudget
Vital Nutrients Hyperbiotics IBS SupportCapsule30 capsulesNot stated on product pageMid
Metagenics UltraFlora IBCapsule30 capsulesNot stated on product pagePremium
Jarrow Formulas Saccharomyces Boulardii + MOSCapsule90 or 180 capsulesNot stated on product pageMid
Klaire Labs Ther-Biotic Saccharomyces BoulardiiCapsule60 or 120 capsulesNot stated on product pageMid
Pure Encapsulations Digestive Enzymes UltraCapsule90 or 180 capsulesNot stated on product pageMid
Enzymedica Digest Gold + ProbioticsCapsule45, 90 or 180 capsulesNot stated on product pageMid
Nordic Naturals Nordic Probiotic DailyCapsule60 capsulesNot stated on product pageMid
Pure Encapsulations Poly-Prebiotic PowderPowder138 gNot stated on product pageMid

Best value: NOW Foods Psyllium Husk Powder and Peppermint Gels are the lowest-priced picks, and both match the ingredients with the strongest evidence in this guide.

Most targeted probiotic: Metagenics UltraFlora IB uses the two strains from its bloating trial, but it is the most expensive pick and its trial used a higher daily amount than the label serving.

Test This with Mito

Gut symptoms have many causes, and a few of them need a diagnosis rather than a supplement. Some signs call for a medical evaluation before you try anything: blood in the stool, unintended weight loss, anemia, symptoms that wake you at night, new symptoms after age 50, or a family history of colorectal cancer, inflammatory bowel disease or celiac disease [1]. Mito offers tests that cover the common questions, with physician-guided interpretation:

  • Celiac Disease Antibody Panel: screens for the antibodies of celiac disease. The ACG recommends celiac testing in people with IBS and diarrhea [1], and testing before you go gluten-free, because the antibodies fall once gluten leaves the diet [18].
  • Calprotectin, Fecal Test: a stool marker of intestinal inflammation that helps tell inflammatory bowel disease apart from IBS when diarrhea is the main symptom [1].
  • H. pylori Urea Breath Test: detects an active Helicobacter pylori infection, a common cause of stomach inflammation and ulcers, when upper abdominal pain or indigestion is the problem [19].
  • Gut Health Test Kit: a DNA snapshot of your gut bacteria you can track over time. It describes your microbiome rather than diagnosing a disease. Our guide to how a gut microbiome test works explains what it can and cannot tell you.
  • Mito Core Panel: 100+ biomarkers including hemoglobin, ferritin, vitamin B12 and hs-CRP, which can flag the anemia, low nutrient levels or inflammation that sometimes sit behind gut symptoms.

How to decide:

  • Ongoing diarrhea or loose stools: the Celiac Disease Antibody Panel and the Calprotectin Fecal Test, before trying supplements.
  • Thinking about going gluten-free: the Celiac Disease Antibody Panel first, while you still eat gluten.
  • Upper abdominal pain, burning or indigestion: the H. pylori Urea Breath Test.
  • Tiredness alongside gut symptoms, or no recent labs: the Mito Core Panel.
  • Curious about your microbiome and want to track it over time: the Gut Health Test Kit.

For testing beyond these, see proper testing for SIBO.

Key Takeaways

  • Match the supplement to the problem: fiber for constipation, peppermint oil for IBS pain, S. boulardii during antibiotics [1][2][6].
  • Psyllium has the best fiber evidence, especially at higher doses taken for at least four weeks [6].
  • Probiotics are strain-specific, and the evidence for IBS is low to very low certainty [10].
  • Daily probiotics in healthy adults have not consistently changed gut bacteria in trials [4].
  • Enzymes help only when they match the food, such as alpha-galactosidase for beans [12].
  • Some symptoms need testing first, including blood in the stool, weight loss and anemia.

Medical Disclaimer

This article is for educational and informational purposes only and does not constitute medical advice. The information provided should not be used for diagnosing or treating a health condition. Always consult with your doctor or qualified healthcare provider before starting any new supplement, making changes to your diet, or if you have questions about a medical condition.

References

  1. Lacy BE, Pimentel M, Brenner DM, et al. ACG Clinical Guideline: Management of Irritable Bowel Syndrome. Am J Gastroenterol. 2021;116(1):17-44. PMID: 33315591

  2. Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2015;42(7):793-801. PMID: 26216624

  3. Su GL, Ko CW, Bercik P, et al. AGA Clinical Practice Guidelines on the Role of Probiotics in the Management of Gastrointestinal Disorders. Gastroenterology. 2020;159(2):697-705. PMID: 32531291

  4. Kristensen NB, Bryrup T, Allin KH, et al. Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials. Genome Med. 2016;8(1):52. PMID: 27159972

  5. Chang L, Chey WD, Imdad A, et al. American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023;164(7):1086-1106. PMID: 37211380

  6. van der Schoot A, Drysdale C, Whelan K, Dimidi E. The effect of fiber supplementation on chronic constipation in adults: an updated systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2022;116(4):953-969. PMID: 35816465

  7. Moayyedi P, Quigley EM, Lacy BE, et al. The effect of fiber supplementation on irritable bowel syndrome: a systematic review and meta-analysis. Am J Gastroenterol. 2014;109(9):1367-1374. PMID: 25070054

  8. Niv E, Halak A, Tiommny E, et al. Randomized clinical study: partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritable bowel syndrome. Nutr Metab (Lond). 2016;13:10. PMID: 26855665

  9. Ingrosso MR, Ianiro G, Nee J, et al. Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome. Aliment Pharmacol Ther. 2022;56(6):932-941. PMID: 35942669

  10. Goodoory VC, Khasawneh M, Black CJ, et al. Efficacy of probiotics in irritable bowel syndrome: systematic review and meta-analysis. Gastroenterology. 2023;165(5):1206-1218. PMID: 37541528

  11. Wilson B, Rossi M, Dimidi E, Whelan K. Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2019;109(4):1098-1111. PMID: 30949662

  12. Ganiats TG, Norcross WA, Halverson AL, et al. Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance. J Fam Pract. 1994;39(5):441-445. PMID: 7964541

  13. Shaukat A, Levitt MD, Taylor BC, et al. Systematic review: effective management strategies for lactose intolerance. Ann Intern Med. 2010;152(12):797-803. PMID: 20404262

  14. Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol. 2012;18(30):4012-4018. PMID: 22912552

  15. Stevenson C, Blaauw R, Fredericks E, et al. Randomized clinical trial: effect of Lactobacillus plantarum 299 v on symptoms of irritable bowel syndrome. Nutrition. 2014;30(10):1151-1157. PMID: 25194614

  16. Ringel-Kulka T, Palsson OS, Maier D, et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011;45(6):518-525. PMID: 21436726

  17. NIH Office of Dietary Supplements. Probiotics: Fact Sheet for Health Professionals. ods.od.nih.gov

  18. Rubio-Tapia A, Hill ID, Semrad C, et al. American College of Gastroenterology Guidelines Update: Diagnosis and Management of Celiac Disease. Am J Gastroenterol. 2023;118(1):59-76. PMID: 36602836

  19. Chey WD, Howden CW, Moss SF, et al. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol. 2024;119(9):1730-1753. PMID: 39626064

Frequently asked questions

What is the best supplement for gut health?

It depends on the problem you want to fix. For constipation, psyllium has the strongest trial record among fiber supplements. For IBS, the American College of Gastroenterology recommends soluble fiber and suggests peppermint oil. For diarrhea during antibiotics, Saccharomyces boulardii lowered how often it happened in trials. For a healthy adult with no symptoms, no supplement has shown a clear benefit, and a fiber-rich diet remains the foundation.

What are the signs of an unhealthy gut?

There is no medical definition of an unhealthy gut. The symptoms people usually mean are bloating, gas, abdominal pain, constipation, diarrhea, or a change in bowel habits that lasts for weeks. Some signs need a medical evaluation rather than a supplement: blood in the stool, unintended weight loss, anemia, symptoms that wake you at night, new symptoms after age 50, or a family history of colorectal cancer, inflammatory bowel disease or celiac disease.

How do I fix my gut health quickly?

There is rarely a quick fix. In fiber trials for constipation, the benefit on stool frequency appeared with higher doses taken for at least four weeks, and the IBS probiotic trials in this guide ran for four to eight weeks. Adding fiber slowly with enough fluid, and changing one thing at a time, makes it easier to tell what is helping.

What is a 7 day gut reset?

A 7 day gut reset is a marketing term, not a medical one. Programs sold under the name usually combine a restrictive diet with cleanses, teas or several supplements, and none has been tested in a published trial. Lasting changes in symptoms depend on what you keep doing after the week ends.

Should I take a probiotic every day for gut health?

For healthy adults, the evidence for a daily probiotic is weak. A systematic review of seven randomized trials in healthy adults found no consistent change in the overall makeup of the gut bacteria compared with placebo. Probiotics have better support for specific uses, such as Saccharomyces boulardii during antibiotics, and the effect depends on the exact strain.

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Mito Concierge

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I can build you a panel, explain what your biomarkers mean, and find the cheapest lab near you.

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