Estradiol (E2) Blood Test
Measure the main estrogen of the reproductive years with a standalone blood test.
- No doctor visit or referral needed
- Members pay our cost on every test, never a markup
- Tracked over time alongside your other results
- HSA/FSA eligible
- Typical results in 1-2 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you · Find labs
Why people order the Estradiol (E2) Blood Test
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Irregular, absent, or unexpectedly changing menstrual cycles
Estradiol can add hormone context when the result is matched to cycle timing, clinical history, and other reproductive hormones.
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Possible early menopause or an atypical menopausal presentation
Typical perimenopause at age 45 or older usually does not require estradiol testing. Testing may be useful when changes occur earlier or the presentation is atypical.
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Symptoms prompting evaluation of possible estrogen excess or deficiency
Symptoms are nonspecific and cannot establish that estradiol is the cause without timing, history, and other clinical information.
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Evaluate a reproductive or menstrual-cycle question
The collection phase and clinical purpose should be defined because estradiol changes substantially through the menstrual cycle.
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Support fertility assessment or monitored fertility treatment
Estradiol may be used alongside other hormones during clinician-directed ovulation induction or assisted reproduction.
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Track estradiol in a defined hormone-treatment context
The selected assay must be appropriate for the expected concentration, and serial testing should preserve method and treatment timing.
Who may consider the Estradiol (E2) Blood Test
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Interpret ovarian, pituitary, hypothalamic, testicular, adrenal, or treatment-related questions
Estradiol is often interpreted with FSH, LH, progesterone, prolactin, AMH, medicines, and the broader clinical picture.
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Choose a sensitive assay when very low concentrations are expected
An ultrasensitive LC/MS assay may be more appropriate than this standard assay in selected low-concentration or interference-prone contexts.
Should I order standard or ultrasensitive estradiol?
This product is a standard immunoassay estradiol test, not an ultrasensitive LC/MS test. If the clinical question depends on measuring very low estradiol concentrations, confirm whether an ultrasensitive product is more appropriate before ordering.
Is standalone estradiol enough, or should I choose the LH, FSH, and estradiol panel?
Choose standalone estradiol when estradiol is the specific measurement needed. Choose the combined panel when LH and FSH are also needed to understand the broader reproductive or pituitary hormone pattern. The combined panel answers a broader question and is a separate product.
Does menstrual-cycle timing affect when I should test?
Yes. Estradiol changes across the menstrual cycle, so the collection date and cycle phase can materially affect interpretation. Follow any timing instructions on the order and record the cycle day when relevant.
Do hormonal medicines or high-dose biotin affect how I should prepare?
They can affect the measured result or its interpretation. Record hormones, fertility medicines, DHEA, other medicines or supplements, and high-dose biotin, then follow the selected order's preparation instructions. Do not stop or change treatment unless a clinician or the order instructions tell you to.
What members say on Trustpilot
What the Estradiol (E2) Blood Test measures
Measure the main estrogen of the reproductive years with a standalone blood test.
Estradiol, also called E2, is the main estrogen during the reproductive years. It also plays important roles in reproductive function and bone health across sexes.
This product measures one estradiol concentration from a venous blood sample. Current provider mappings report the source result in pg/mL under LOINC 2243-4. The result must be interpreted with the performing laboratory's assay, unit, reference information, and the person's age, sex, menstrual or reproductive context, pregnancy status, medicines, and testing purpose.
This is the standard Estradiol (E2) product. It is not the separate Estradiol (E2), Ultrasensitive product, a fractionated estrogen panel, an estrone test, an estriol test, or the LH, FSH, and Estradiol panel. It does not diagnose infertility, menopause, PCOS, ovarian failure, a pituitary disorder, a tumor, or another condition by itself.
- Specimen
- Serum or plasma
- Measures
- Mass concentration
- Reported biomarkers
- Estradiol
- Biomarker count
- 1 biomarker
- Fasting
- Special preparation needed (cycle timing may matter)
- Results
- On your Mito dashboard in 1-2 days, with your range explained
- Reference ranges
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Labcorp Test 004515 selected Quest Diagnostics Test 4021 selected
Labcorp Test 004515
- Adult male 7.6-42.6 pg/mL
- Adult female, follicular 12.5-166.0 pg/mL
- Adult female, ovulation 85.8-498.0 pg/mL
- Adult female, luteal 43.8-211.0 pg/mL
- Adult female, postmenopausal <6.0-54.7 pg/mL
- Pregnancy, first trimester 215.0 to >4300.0 pg/mL
Quest Diagnostics Test 4021
- Female, follicular phase 30-144 pg/mL
- Female, mid-cycle 64-357 pg/mL
- Female, luteal phase 56-214 pg/mL
- Female, postmenopausal ≤31 pg/mL
- Male ≤39 pg/mL
Your results
How to understand your Estradiol (E2) Blood Test result
Use the performing laboratory's assay-specific reference information. Menstrual-cycle phase is not an age band, and serial results should preserve laboratory, method, unit, cycle timing, treatment timing, and relevant medicine use when possible.
Low estradiol for the relevant context
A low result can be appropriate for some life stages and cycle phases, or it can reflect ovarian, pituitary, hypothalamic, nutritional, exercise-related, treatment-related, or other factors. One low result does not diagnose menopause, ovarian insufficiency, hypothalamic amenorrhea, or another condition. A standard assay may also be less informative when very low concentrations are expected.
Expected for the relevant phase or treatment context
An estradiol value is meaningful only when matched to sex, age, cycle phase, pregnancy status, medicines, treatment timing, and the assay used. A value that fits one phase or population may not fit another, so there is no single universal normal range.
High estradiol for the relevant context
A high result can be appropriate during some cycle phases, pregnancy, or fertility treatment, or it can reflect medicines, hormone production, or another clinical factor. One high result does not diagnose PCOS, an estrogen-producing tumor, or estrogen dominance. Symptoms, timing, other hormones, and the purpose of testing guide interpretation.
How much the Estradiol (E2) Blood Test costs
Compare exact Mito member and non-member prices with recently checked comparable offers. Collection and lab fees are shown separately.
| Lab | Test price | Collection or lab fee |
|---|---|---|
| Mito member | $5.40 | $15.00 Added once per order |
| Mito non-member | $7.56 | $15.00 Added once per order |
| Goodlabs | $8.00 | $12.00 $12 per visit, included in the final checkout total |
| Marek Diagnostics | $20.00 | $10.00 $10 added at checkout for an individual biomarker or custom panel |
| DrSays | $16.99 | $9.99 $9.99 collection fee per order |
| Jason Health | $30.00 | $18.00 $18 lab collection fee per order |
| Ulta Lab Tests | $30.95 | $12.95 $12.95 standard draw fee; some locations may charge more |
| Walk-In Lab | $49.00 | $6.00 $6 per-order physician fee |
Mito prices come from the live catalog for the selected provider. Competitor prices were checked August 22, 2026. Published standalone item price plus the separately disclosed collection or checkout fee.
See the full Estradiol (E2) Blood Test cost comparison for provider details and comparison notes.
How it works
What to expect from your Estradiol (E2) Blood Test
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your schedule, usually 15 minutes or less. Walk-in and appointments available. Follow the preparation instructions for your order.
- 3 Results in 1-2 days
Your result posts straight to your dashboard as soon as the lab completes it.
- 4 Expert guidance
With membership, a clinician reviews your result and a personalized action plan follows, with clear next steps.
Every result comes with a plan
A number on its own does not tell you much. Membership is what turns it into next steps, and keeps track of what changes.
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
Estradiol (E2) Blood Test testing you can trust
Run to clinical-grade standards
- Processed at the same CLIA and CAP-accredited national labs your doctor uses
- Order online, no doctor visit or referral needed
- Your data is encrypted, handled under HIPAA, and never sold
Overseen by our Care Team Lead
Every result, including your Mito Brain analysis, is checked by Rhonda Collins, FNP-C, our Care Team Lead and a board-certified Family Nurse Practitioner with over 15 years of nursing experience across cardiac ICU, primary care, and dermatology.
Meet RhondaEverything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
Common Estradiol (E2) Blood Test questions
What does this product measure?
Which estradiol test should I choose?
Does cycle day matter?
Can one estradiol result diagnose menopause?
Can this test diagnose PCOS or infertility?
Can medicines or supplements affect the result?
Do results from different labs match exactly?
Is this the same as a total or fractionated estrogen test?
How do availability and prices vary by state?
Available in all 50 states and Washington, DC.
| States | Provider | Availability | Member price | Non-member price |
|---|---|---|---|---|
| All states and DC except NJ, NY, and RI | Labcorp | Available | $22.64 | $31.70 |
| All states and DC except NJ, NY, and RI | Quest Diagnostics | Available | $5.40 | $7.56 |
| NJ, NY, and RI | BioReference | Available | $30.18 | $42.26 |