Tryptase
The main blood marker of mast cell activity, central to working up anaphylaxis and mast cell disorders.
Consider this test if:
- Recurrent flushing, hives, abdominal cramping, or unexplained low blood pressure suggesting mast cell activation
- Confirming whether a severe allergic episode was true anaphylaxis
- Evaluating possible mastocytosis or hereditary alpha tryptasemia
- A persistently raised tryptase found on prior testing that needs a baseline established
- Frequent or severe insect sting, food, or drug reactions under investigation
- HSA/FSA eligible
- Results delivered to your dashboard · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required. Timing is what matters: to capture anaphylaxis, the sample should be drawn within about 30 minutes to 6 hours of the suspected event, then compared against a baseline level drawn at least 24 hours after all symptoms have fully resolved. A single resting measurement is fine for assessing basal tryptase.
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What this test is for
Tryptase is a serine protease stored in mast cells and released both steadily at baseline and in larger amounts when mast cells activate. A persistently elevated basal level points to mast cell burden or hyperactivity: the most common cause is hereditary alpha tryptasemia, but it is also seen in mastocytosis and other myeloid disorders, allergic disease, chronic kidney failure, and some chronic infections. A transient spike above your own baseline is one of the few objective signs that an acute reaction was true anaphylaxis. The serum test detects total tryptase and does not separate the alpha and beta forms, so a single elevated number is interpreted with your history and, when relevant, a repeat draw.
- Specimen
- Serum or plasma
- Measures
- Mass concentration
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Fast, dashboard-delivered results
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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