Tissue Transglutaminase Antibody (tTG IgA)
The first-line screening marker for celiac disease and gluten-sensitive enteropathy.
Consider this test if:
- Chronic diarrhea, bloating, gas, or unexplained weight loss
- Iron-deficiency anemia, fatigue, or nutrient malabsorption without a clear cause
- An itchy, blistering rash (dermatitis herpetiformis) or a first-degree relative with celiac disease
- Confirming whether a gluten-free diet is bringing antibody levels down
- Investigating symptoms before removing gluten, since testing is only accurate while eating gluten
- HSA/FSA eligible
- Typical results in 2-3 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required. Keep eating a normal gluten-containing diet until the blood is drawn, since cutting gluten lowers antibody levels and can produce a false negative. If you have already gone gluten-free, the result may understate disease, so discuss timing first.
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What this test is for
Tissue transglutaminase IgA (tTG IgA) is the antibody the immune system produces against an enzyme in the gut lining when gluten triggers inflammation in celiac disease. It is the single best blood test for screening celiac disease and dermatitis herpetiformis, with high sensitivity in people eating a normal gluten-containing diet. A high level points strongly toward celiac disease and warrants confirmation, usually with an intestinal biopsy; antibody levels fall over time once gluten is removed, so the test also tracks whether a gluten-free diet is working. One important caveat: people with selective IgA deficiency can have a falsely low result, which is why total IgA or the IgG-based antibodies (deamidated gliadin or tTG IgG) are checked when IgA is low.
This is the IgA tissue transglutaminase test, the recommended starting point for most people. The separate tTG IgG and deamidated gliadin IgG tests are used mainly when IgA deficiency is present, and the broader celiac panels add those antibodies for harder diagnostic cases.
- Specimen
- Serum
- Measures
- Concentration
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 2-3 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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$9 /mo
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Without membership
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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