RNP Antibody
Autoantibodies that help pin down lupus, mixed connective tissue disease, and related autoimmune conditions.
Consider this test if:
- Joint pain, fatigue, photosensitive rash, or Raynaud's suggesting connective tissue disease
- A positive ANA that needs to be characterized further
- Suspected lupus, mixed connective tissue disease, Sjögren's, scleroderma, or myositis
- Dry eyes and mouth, muscle weakness, or skin tightening alongside systemic symptoms
- Clarifying an overlap syndrome where features point to more than one autoimmune condition
- HSA/FSA eligible
- Typical results in 2-3 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required, and timing during the day does not affect the result. A standard blood draw is all that is needed.
Video consult with your Care Team
A 1:1 call to discuss your health.
What members say on Trustpilot
What this test is for
This profile measures antibodies against extractable nuclear antigens, including RNP, Sm, SS-A, SS-B, Scl-70, Jo-1, centromere B, chromatin, ribosomal P, and double-stranded DNA. These autoantibodies are markers of systemic autoimmune disease: Sm and ribosomal P are highly specific for systemic lupus erythematosus, high-titer RNP points toward mixed connective tissue disease, SS-A and SS-B are linked to Sjögren's, Scl-70 and centromere to scleroderma, and Jo-1 to inflammatory myositis. It is typically ordered to investigate a cluster of symptoms such as joint pain, persistent fatigue, photosensitive rash, Raynaud's, dry eyes and mouth, or muscle weakness, often after a positive ANA screen. Because each antibody narrows the differential differently, the pattern across the panel matters as much as any single positive.
The separate Sm/RNP Antibody test measures the combined SmRNP complex, which boosts sensitivity but cannot distinguish Sm from RNP specificity; this broader profile reports the individual antibodies so the result can be tied to a specific condition.
- Specimen
- Serum
- Measures
- Concentration
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 2-3 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
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Without membership
$0
pay as you go
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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