Senolytic Px

Senolytic supports longevity and healthy aging.* Cell senescence is a natural process where a cell stops dividing due to various stressors such as aging, oxidation, or DNA damage, but it doesn’t die. This condition is often coined “zombie cell” because it continues to be metabolically active while releasing inflammatory chemicals (called SASP). SASP can spread and damage nearby healthy cells, thus contributing to aging and age-related diseases.

Developing senolytic therapies that selectively target senescent cells may help delay the onset of aging signs and symptoms and improve resiliency and longevity.* Senolytic treatment is often recommended as “hit and run” dosing, meaning high doses are used for a series of days each month, and then take a break for the remainder of the month.*

Health Benefits:

• Supports healthy senescence by clearing out “zombie cells” to better support longevity through optimal cell health and function.*
• Supports healthy neuronal cells, cognitive function, and mitochondrial function throughout ones senior years.*
• Safe, natural support for brain health and focus for seniors challenged with frailty, age-related decline of metabolic and neurological functions, and the aging immune system.*

Formulation Features:

• This unique combination of senolytic phytonutrients features 1724 mg of the bioactive flavonoid Fisetin, optimized by adding fenugreek seed and quercetin.
• Black pepper is added to enhance fisetin bioavailability in the gastrointestinal system.*
• “Hit and run” dosing is recommended; take high doses each month for a series of days, and then take a break for the remainder of the month. Fisetin is present in low concentrations in many fruits and vegetables such as mangoes, apples, strawberries, kiwis, grapes, persimmon, onions, and smoke tree (Cotinus coggygria), the source for dietary supplements. Fisetin has been shown to affect multiple pathways involved in healthy aging and is reported to act as a neurotrophic, botanical antioxidant, and neuroprotective agent.*

Fisetin helps maintain healthy mitochondrial function in the presence of oxidative stress, preserves glutathione supply, and supports healthy cellular metabolism.* It demonstrates a significant level of nerve and brain protection, boosting memory and new nerve cell growth.* Fisetin is now in Phase II Clinical studies. Fenugreek Fenugreek contains galactomannans, compounds that boost the polyphenol fisetin’s bioavailability.* Fenugreek has neuroprotective activity, positive effects on lipid and glucose metabolic function, as well as a modulatory effect on cognitive functions and mood states.*

Quercetin, a flavonoid sourced from the plant Sophora japonica, has been researched for its modulating and regulatory action, supporting healthy inflammation and immunity along with mast cell stabilization.* Black pepper contains the active compound piperine, which enhances the bioavailability of many substances, including plant compounds.* Supplementation Take 5 capsules daily for 3 consecutive days per month or as directed by your health care practitioner.

Restorative Formulations’ clean, pure formulas are free from magnesium stearate, binders, and artificial colors or flavors. We package exclusively in amber glass bottles, not plastic. All products are made in North America with ecologically sourced herbs, from the US whenever possible, harvested at peak potency to avoid solvents. Every lot is tested—raw materials and finished products—using HPLC by third-party labs.