PSA, Total with Reflex to PSA, Free
The main prostate screening marker, tracking changes that can signal enlargement, inflammation, or cancer.
Consider this test if:
- Routine prostate screening after age 50, or earlier with a family history of prostate cancer
- Urinary symptoms like weak stream, frequent nighttime urination, or difficulty starting
- Tracking a known enlarged prostate (BPH) or prior borderline PSA over time
- Following up an abnormal digital rectal exam
- Establishing a baseline PSA to compare against future results
- HSA/FSA eligible
- Typical results in 1-2 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Reflex testing
If your total PSA falls in the borderline range (typically 4.0 to 10.0 ng/mL), a free PSA test runs automatically to calculate the percent free PSA, which helps distinguish benign causes from ones that warrant biopsy. This is done at no additional cost.
Pre-test considerations
Avoid ejaculation, vigorous cycling, and prostate exams for about 48 hours before the draw, since these can transiently raise PSA. Recent urinary infection or prostate procedures also elevate the result, so time the test away from them. No fasting required.
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What this test is for
PSA (prostate-specific antigen) is a protein made by the prostate, and its level in blood rises with changes to prostate tissue. Elevated total PSA reflects a range of causes: benign prostatic hyperplasia (BPH), prostatitis, recent trauma or prostate manipulation, and prostate cancer. It is the standard blood marker for prostate screening and for tracking a known prostate condition over time. A single elevated result does not mean cancer, since BPH and inflammation raise it too, which is exactly why the free PSA reflex is useful in the borderline range.
This is the standard total PSA test measured to routine sensitivity. The separate ultrasensitive PSA is used mainly to monitor for recurrence after prostate cancer treatment, where very small changes near zero matter.
Biomarkers tested
Includes 1 biomarker
PSA is a protein made by prostate cells, and this test measures its total concentration in blood without separating the free and bound fractions. Levels rise with prostate enlargement, inflammation (prostatitis), and prostate cancer, which is why it's the standard tool for prostate cancer screening in men over 50 (or earlier with family history) and for tracking known prostate conditions over time. Rising trends matter as much as single values, so testing PSA on a routine schedule lets you catch upward movement early rather than reacting to a single high number.
- Specimen
- Serum or plasma
- Measures
- Mass concentration
Free PSA measures the fraction of prostate specific antigen that circulates unbound to blood proteins, as opposed to total PSA, which counts both bound and free forms. The ratio of free to total PSA helps distinguish benign prostate enlargement from prostate cancer when total PSA falls in a borderline range, since cancerous tissue tends to release more of the protein-bound form while benign tissue releases more free PSA. A low free PSA percentage raises suspicion for cancer and often prompts further evaluation, while a higher percentage supports a benign cause like BPH and can help men avoid an unnecessary biopsy.
- Specimen
- Serum or plasma
- Measures
- Mass concentration
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 1-2 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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Without membership
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost — covering the lab and what it takes to run the service — never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9/mo, and you still pay the lab’s order fee. Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results post to your dashboard once your lab completes them, then a clinician reviews them and your full analysis and personalized action plan (with clear next steps) follow. Turnaround varies by test: specialty assays and at-home kits take longer, and each test shows its expected turnaround before you buy.
Do I need a doctor’s order?
No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.
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