Prothrombin (Factor II) 20210G>A Genotype
An inherited mutation that raises the risk of abnormal blood clots in the veins.
Consider this test if:
- A personal history of unexplained deep vein thrombosis or pulmonary embolism, especially before age 50
- A first-degree relative with a known clotting disorder or recurrent blood clots
- Planning estrogen-containing contraception, hormone therapy, or pregnancy and weighing clotting risk
- A clot that occurred without an obvious trigger, or recurrent clots
- Already known to carry Factor V Leiden and clarifying combined inherited risk
- HSA/FSA eligible
- Results delivered to your dashboard · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting or special preparation required. This is a DNA test, so results are unaffected by recent meals, medications, or anticoagulant therapy, and timing does not matter. Anticoagulants do not change the genotype, though they do affect clotting tests like PT/INR.
Video consult with your Care Team
A 1:1 call to discuss your health.
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What this test is for
The prothrombin G20210A mutation is one of the most common inherited causes of venous thrombosis, including deep vein thrombosis and pulmonary embolism. This test reads the F2 gene directly to determine whether you carry one copy (heterozygous) or two copies of the variant, which increases the production of clotting factor II. About 2.3% of the general population carries one copy, compared with roughly 6.2% of people with venous thrombosis and 18% of those with a strong family history of clots. The mutation rarely causes problems on its own; risk compounds with other factors such as Factor V Leiden, estrogen-containing contraceptives, pregnancy, surgery, immobility, and smoking.
This is a one-time genetic test, separate from prothrombin time (PT/INR), which measures how fast your blood is clotting right now, and from des-gamma-carboxy prothrombin, a liver and tumor marker. Because your genotype does not change, a single result settles it for life.
- Specimen
- Blood or tissue
- Method
- Molecular (genetic)
- Measures
- Genotype
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Fast, dashboard-delivered results
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
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Without membership
$0
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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