Procollagen Type I Intact N-Terminal Propeptide (PINP)
A leading marker of bone formation, useful for tracking osteoporosis treatment response.
Consider this test if:
- Starting or already on osteoporosis treatment and want to confirm it is working
- Diagnosed with osteoporosis or osteopenia and tracking bone turnover between DEXA scans
- Postmenopausal and assessing whether bone turnover is elevated
- Evaluating conditions that raise bone turnover, such as Paget's disease or hyperparathyroidism
- Establishing a baseline before beginning antiresorptive or anabolic bone therapy
- HSA/FSA eligible
- Typical results in 3-5 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required and food does not affect the result. PINP has very low circadian variation, so collection time is flexible. For treatment monitoring, draw a baseline before starting therapy and recheck three to six months later, ideally under similar conditions for a clean comparison.
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What this test is for
PINP (procollagen type I N-terminal propeptide) is released when osteoblasts build new bone collagen, so its level in blood reflects the rate of bone formation. It is the bone formation marker preferred by the International Osteoporosis Foundation and the National Bone Health Alliance, mainly because it responds quickly to treatment: levels shift within months, long before changes show up on a DEXA scan. High PINP indicates accelerated bone turnover, seen in osteoporosis, Paget's disease, primary hyperparathyroidism, renal osteodystrophy, and bone metastases. When monitoring osteoporosis therapy, a drop of roughly 21% or more from your pretreatment baseline at three to six months signals an adequate response, which makes PINP a practical check on whether a drug is working and whether you are taking it consistently. PINP has very low day-to-day and circadian variation and is not affected by food, so timing is forgiving.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 3-5 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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$9 /mo
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost — covering the lab and what it takes to run the service — never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9/mo, and you still pay the lab’s order fee. Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results post to your dashboard once your lab completes them, then a clinician reviews them and your full analysis and personalized action plan (with clear next steps) follow. Turnaround varies by test: specialty assays and at-home kits take longer, and each test shows its expected turnaround before you buy.
Do I need a doctor’s order?
No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.
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