Procollagen Type I Intact N-Terminal Propeptide (PINP)
A leading marker of bone formation, useful for tracking osteoporosis treatment response.
Consider this test if:
- Starting or already on osteoporosis treatment and want to confirm it is working
- Diagnosed with osteoporosis or osteopenia and tracking bone turnover between DEXA scans
- Postmenopausal and assessing whether bone turnover is elevated
- Evaluating conditions that raise bone turnover, such as Paget's disease or hyperparathyroidism
- Establishing a baseline before beginning antiresorptive or anabolic bone therapy
- HSA/FSA eligible
- Typical results in 3-5 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required and food does not affect the result. PINP has very low circadian variation, so collection time is flexible. For treatment monitoring, draw a baseline before starting therapy and recheck three to six months later, ideally under similar conditions for a clean comparison.
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What this test is for
PINP (procollagen type I N-terminal propeptide) is released when osteoblasts build new bone collagen, so its level in blood reflects the rate of bone formation. It is the bone formation marker preferred by the International Osteoporosis Foundation and the National Bone Health Alliance, mainly because it responds quickly to treatment: levels shift within months, long before changes show up on a DEXA scan. High PINP indicates accelerated bone turnover, seen in osteoporosis, Paget's disease, primary hyperparathyroidism, renal osteodystrophy, and bone metastases. When monitoring osteoporosis therapy, a drop of roughly 21% or more from your pretreatment baseline at three to six months signals an adequate response, which makes PINP a practical check on whether a drug is working and whether you are taking it consistently. PINP has very low day-to-day and circadian variation and is not affected by food, so timing is forgiving.
- Specimen
- Serum or plasma
- Measures
- Mass concentration
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 3-5 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
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Without membership
$0
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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