Saffro-Calm Plus

Herbal-based oral spray for natural stress and mood support

• Promotes emotional wellness and a positive outlook
• Provides support for occasional stress and uneasiness
• Promotes sense of relaxation without drowsiness
• Enhances ability to sleep

Patient One Saffro-Calm Plus oral spray is formulated with a unique and synergistic combination of botanicals to calm feelings of occasional stress without drowsiness. Because the botanicals in Saffro-Calm Plus have been shown to interact with the body's endocannabinoid system (ECS), this formula is part of our ECS Synergy™ series.

Our pleasant tasting spray is for oral use, to be taken by mouth, and may be used by adults and adolescents. Saffro-Calm Plus is convenient to carry when on the go or to easily access on a bedside table.

Key Ingredients
affron® Saffron

In more than 5 published human clinical studies, affron® Saffron has been shown as effective at a low daily dose of 28 mg to calm occasional irritability and stress, promote mental balance, maintain a healthy mood and to support restful sleep. Made from Spanish saffron (Crocus sativus), affron's patented formulation is standardized to provide 3.5% Lepticrosalides®, a complex of bioactive compounds responsible for its beneficial and organoleptic properties.

Affron's dual mechanisms of action include

• reuptake inhibition of dopamine, norepinephrine and serotonin, increasing the concentration of these neurotransmitters in the synaptic cleft of neurons, thereby improving mood balance, and
• antioxidant effect against the excessive oxidative stress produced during anxiety or stress processes in the central nervous system.

Scientific studies have associated saffron with modulation of the body's endocannabinoid system. 

Echinacea augustifolia 

Saffro-Calm Plus also includes Echinacea augustifolia for added support in reducing occasional tension and promoting a relaxed, positive mood. While this herb is typically associated with immune system support, the root extract in our formula contains alkamides along with echinacosides. It has been found that alkamides bind significantly to and activate the body's cannabinoid (CB2) receptors in the endocannabinoid system. 

Alkamides are bioactive compounds that show structural similarity with anandamide, an endogenous ligand of cannabinoid receptors. Anandamide is a neurotransmitter that binds to cannabinoid receptors in the brain and body, stimulating a sense of happiness and mental balance. Anandamide is a little-known brain chemical that's been called the “bliss molecule” for the role it plays in producing feelings of happiness. 

Saffro-Calm Plus:  an ECS Synergy™ Formula

Numerous plants and compounds have been identified whose active agents stimulate, antagonize, or modulate different aspects of the body’s endocannabinoid system (ECS). Perhaps the most well known plant in this group is cannabis, or hemp, which produces cannabinoids that may release neurotransmitters that communicate vital information to regulate many physiological systems in the brain and body.

But beyond cannabis, additional botanicals have been studied and found to exert similar direct or indirect modulatory effects on the ECS, offering therapeutic potential.

In this Saffro-Calm Plus ECS Synergy™ formula, we’ve combined two non-hemp botanicals, saffron and echinacea, that are effective in engaging the ECS. In particular, these botanicals promote beneficial effects on key neurotransmitters that moderate mood and stress response.