Immunoglobulin G (IgG) Subclasses Panel
Breaks total IgG into its four subclasses to find selective antibody deficiencies that a normal total can hide.
Consider this test if:
- Recurrent sinus, ear, bronchial, or respiratory infections without a clear cause
- A normal total IgG but ongoing suspicion of an antibody deficiency
- Following up an immunodeficiency or poor response to vaccination
- Tracking immune status in a known subclass deficiency over time
- HSA/FSA eligible
- Results delivered to your dashboard · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required. Recent immunoglobulin therapy, plasma infusions, or certain immunosuppressive medications can alter results, so note them. Subclass reference ranges vary with age, which matters most when interpreting results in children.
Video consult with your Care Team
A 1:1 call to discuss your health.
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What this test is for
IgG is the main antibody class defending against infection, and it comes in four subclasses (IgG1, IgG2, IgG3, IgG4) that handle different jobs: IgG1 and IgG3 respond mainly to proteins and viruses, while IgG2 covers polysaccharide-coated bacteria. This panel measures total IgG plus each subclass, which matters because one subclass can run low while total IgG looks normal, leaving recurrent sinus, ear, and respiratory infections unexplained. It is used to evaluate frequent or unusually severe infections, suspected immunodeficiency, and conditions involving altered immune regulation. An isolated low subclass is interpreted alongside infection history and vaccine-response testing, since values shift with age and a single low reading is not the same as a clinically meaningful deficiency.
This is the detailed breakdown. The separate total IgG test and the Immunoglobulins Panel (IgA, IgG, IgM) measure overall antibody levels and are the right starting point when you want a broad immunoglobulin overview rather than a subclass workup.
Biomarkers tested
Includes 5 biomarkers
- Specimen
- Serum
- Measures
- Mass concentration
- Specimen
- Serum
- Measures
- Mass concentration
- Specimen
- Serum
- Measures
- Mass concentration
- Specimen
- Serum
- Measures
- Mass concentration
- Specimen
- Serum or plasma
- Measures
- Mass concentration
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Fast, dashboard-delivered results
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
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Without membership
$0
pay as you go
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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