Immunoglobulin G (IgG) Subclasses Panel
Breaks total IgG into its four subclasses to find selective antibody deficiencies that a normal total can hide.
Consider this test if:
- Recurrent sinus, ear, bronchial, or respiratory infections without a clear cause
- A normal total IgG but ongoing suspicion of an antibody deficiency
- Following up an immunodeficiency or poor response to vaccination
- Tracking immune status in a known subclass deficiency over time
- HSA/FSA eligible
- Results delivered to your dashboard · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required. Recent immunoglobulin therapy, plasma infusions, or certain immunosuppressive medications can alter results, so note them. Subclass reference ranges vary with age, which matters most when interpreting results in children.
Video consult with your Care Team
A 1:1 call to discuss your health.
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What this test is for
IgG is the main antibody class defending against infection, and it comes in four subclasses (IgG1, IgG2, IgG3, IgG4) that handle different jobs: IgG1 and IgG3 respond mainly to proteins and viruses, while IgG2 covers polysaccharide-coated bacteria. This panel measures total IgG plus each subclass, which matters because one subclass can run low while total IgG looks normal, leaving recurrent sinus, ear, and respiratory infections unexplained. It is used to evaluate frequent or unusually severe infections, suspected immunodeficiency, and conditions involving altered immune regulation. An isolated low subclass is interpreted alongside infection history and vaccine-response testing, since values shift with age and a single low reading is not the same as a clinically meaningful deficiency.
This is the detailed breakdown. The separate total IgG test and the Immunoglobulins Panel (IgA, IgG, IgM) measure overall antibody levels and are the right starting point when you want a broad immunoglobulin overview rather than a subclass workup.
Biomarkers tested
Includes 5 biomarkers
- Specimen
- Serum
- Measures
- Mass concentration
- Specimen
- Serum
- Measures
- Mass concentration
- Specimen
- Serum
- Measures
- Mass concentration
- Specimen
- Serum
- Measures
- Mass concentration
- Specimen
- Serum or plasma
- Measures
- Mass concentration
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Fast, dashboard-delivered results
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
cancel anytime
Without membership
$0
pay as you go
At-cost pricing on labs, scans, and more
Priority turnaround on your results
On-demand clinician consults when you need guidance
Personalized action plans across supplements, exercise, nutrition, and sleep
AI health coaching to help you act on your results
Year-round medical support, with in-chat clinician escalation
All your health records in one personal vault, with trends and biological age tracking
Early access to new diagnostics and product releases
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost — covering the lab and what it takes to run the service — never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9/mo, and you still pay the lab’s order fee. Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results post to your dashboard once your lab completes them, then a clinician reviews them and your full analysis and personalized action plan (with clear next steps) follow. Turnaround varies by test: specialty assays and at-home kits take longer, and each test shows its expected turnaround before you buy.
Do I need a doctor’s order?
No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.
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