HIV-1/2 Antigen and Antibodies, Fourth Generation, with Reflexes
The standard fourth-generation screen for HIV-1 and HIV-2, able to catch infection earlier than antibody-only tests.
Consider this test if:
- Starting or restarting PrEP and confirming your status first
- A possible exposure through sex, needle sharing, or occupational contact
- Routine screening as recommended for anyone aged 15 to 65, or during pregnancy
- Establishing a documented baseline before a new relationship or fertility planning
- HSA/FSA eligible
- Typical results in 1-2 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Reflex testing
If your initial screen comes back positive, follow-up testing runs automatically to confirm the result and distinguish HIV-1 from HIV-2, including RNA testing when needed to catch acute infection before antibodies form. These reflex steps are included at no additional cost.
Pre-test considerations
No fasting required and no special timing during the day. Timing relative to exposure matters: the p24 antigen becomes detectable roughly two to four weeks after infection, so a very recent exposure can still test negative and may need a repeat test after the window closes.
Video consult with your Care Team
A 1:1 call to discuss your health.
What members say on Trustpilot
What this test is for
This is a fourth-generation HIV screen that detects HIV-1 and HIV-2 antibodies plus the HIV-1 p24 antigen in a single test. Because p24 antigen appears before antibodies develop, it can identify acute infection during the early window when antibody-only tests still read negative. It is the CDC-recommended starting point for HIV diagnosis in adults, pregnant women, and children two years and older, with over 99% sensitivity and specificity. It is the right test for routine screening, for confirming status before starting PrEP, and for checking after a possible exposure once enough time has passed for the marker to turn positive.
This catalog item is the standalone fourth-generation screen with the full reflex algorithm. The same antigen/antibody assay also appears bundled inside our broader STI serology panel alongside syphilis, hepatitis B, hepatitis C, and herpes.
- Specimen
- Serum or plasma
- Method
- Immunoassay
- Measures
- Presence / threshold
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 1-2 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
cancel anytime
Without membership
$0
pay as you go
At-cost pricing on labs, scans, and more
Supplements at 30% off retail prices Coming soon
On-demand clinician consults when you need guidance
Personalized action plans across supplements, exercise, nutrition, and sleep
AI health coaching to help you act on your results
Year-round medical support, with in-chat clinician escalation
All your health records in one personal vault, with trends and biological age tracking
Early access to new diagnostics and product releases
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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