F2-Isoprostane/Creatinine Ratio
The most validated marker of systemic oxidative stress, the damage that drives aging and atherosclerosis.
Consider this test if:
- Smoking, poor diet, obesity, or other lifestyle factors that raise oxidative burden
- A family history of cardiovascular disease, or existing hyperlipidemia
- Wanting an objective baseline for oxidative stress before changing diet, training, or quitting smoking
- Checking whether a sustained lifestyle change has actually lowered your oxidative burden
- HSA/FSA eligible
- Results delivered to your dashboard · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
Provided as a random urine sample, so no fasting or special timing is required. Because the result reflects recent oxidative load, keep conditions consistent between tests if you are tracking change, and note that smoking shortly before collection raises the level.
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What this test is for
F2-isoprostanes are compounds formed when free radicals attack fats in your cell membranes, and the urinary level is considered the gold-standard measure of oxidative stress in the body. Dividing by urine creatinine corrects for how dilute the sample is, so the ratio reflects true oxidative burden rather than how much water you drank. High levels track with the conditions oxidative stress promotes: atherosclerosis, cardiovascular disease, and certain cancers, and they tend to rise with smoking, poor diet, obesity, and hyperlipidemia. This is a research-grade marker of a biological process, not a diagnosis of any single disease, so it is most useful as a baseline you can move with lifestyle change. It is one of the few oxidative-stress measures with enough validation to be worth tracking over time.
Biomarkers tested
Includes 3 biomarkers
Urine creatinine tracks a waste product muscle breaks down at a steady rate, which makes it the reference point for judging whether a urine sample is concentrated or diluted. Labs use it to normalize other urine markers, most importantly albumin, into a ratio (ACR) that actually reflects kidney filtering rather than how much water you drank that morning. On its own it is rarely the number you care about, but pair it with albumin and it becomes one of the earliest ways to catch kidney strain from diabetes, high blood pressure, or high-protein training loads before symptoms show up.
- Specimen
- Urine
- Measures
- Mass concentration
- Specimen
- Urine
- Measures
- Mass concentration
- Specimen
- Urine
- Measures
- Ratio
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Fast, dashboard-delivered results
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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$9 /mo
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Without membership
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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