F2-Isoprostane/Creatinine Ratio
The most validated marker of systemic oxidative stress, the damage that drives aging and atherosclerosis.
Consider this test if:
- Smoking, poor diet, obesity, or other lifestyle factors that raise oxidative burden
- A family history of cardiovascular disease, or existing hyperlipidemia
- Wanting an objective baseline for oxidative stress before changing diet, training, or quitting smoking
- Checking whether a sustained lifestyle change has actually lowered your oxidative burden
- HSA/FSA eligible
- Results delivered to your dashboard · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
Provided as a random urine sample, so no fasting or special timing is required. Because the result reflects recent oxidative load, keep conditions consistent between tests if you are tracking change, and note that smoking shortly before collection raises the level.
Video consult with your Care Team
A 1:1 call to discuss your health.
What members say on Trustpilot
What this test is for
F2-isoprostanes are compounds formed when free radicals attack fats in your cell membranes, and the urinary level is considered the gold-standard measure of oxidative stress in the body. Dividing by urine creatinine corrects for how dilute the sample is, so the ratio reflects true oxidative burden rather than how much water you drank. High levels track with the conditions oxidative stress promotes: atherosclerosis, cardiovascular disease, and certain cancers, and they tend to rise with smoking, poor diet, obesity, and hyperlipidemia. This is a research-grade marker of a biological process, not a diagnosis of any single disease, so it is most useful as a baseline you can move with lifestyle change. It is one of the few oxidative-stress measures with enough validation to be worth tracking over time.
Biomarkers tested
Includes 3 biomarkers
Urine creatinine tracks a waste product muscle breaks down at a steady rate, which makes it the reference point for judging whether a urine sample is concentrated or diluted. Labs use it to normalize other urine markers, most importantly albumin, into a ratio (ACR) that actually reflects kidney filtering rather than how much water you drank that morning. On its own it is rarely the number you care about, but pair it with albumin and it becomes one of the earliest ways to catch kidney strain from diabetes, high blood pressure, or high-protein training loads before symptoms show up.
- Specimen
- Urine
- Measures
- Mass concentration
- Specimen
- Urine
- Measures
- Mass concentration
- Specimen
- Urine
- Measures
- Ratio
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Fast, dashboard-delivered results
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
-
Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
-
Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
-
Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
cancel anytime
Without membership
$0
pay as you go
At-cost pricing on labs, scans, and more
Priority turnaround on your results
On-demand clinician consults when you need guidance
Personalized action plans across supplements, exercise, nutrition, and sleep
AI health coaching to help you act on your results
Year-round medical support, with in-chat clinician escalation
All your health records in one personal vault, with trends and biological age tracking
Early access to new diagnostics and product releases
More tests to consider
Loading essentials…
Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost — covering the lab and what it takes to run the service — never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9/mo, and you still pay the lab’s order fee. Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results post to your dashboard once your lab completes them, then a clinician reviews them and your full analysis and personalized action plan (with clear next steps) follow. Turnaround varies by test: specialty assays and at-home kits take longer, and each test shows its expected turnaround before you buy.
Do I need a doctor’s order?
No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.
Recently viewed
Loading essentials…