Double-Stranded DNA (dsDNA) Antibody
One of the most specific antibodies for systemic lupus, and a marker that tracks disease activity over time.
Consider this test if:
- A positive ANA and symptoms like joint pain, persistent fatigue, a facial rash, or photosensitivity
- Following known lupus to monitor disease activity, especially kidney involvement
- Tracking response to lupus therapy over time
- Investigating unexplained kidney inflammation alongside other autoimmune markers
- HSA/FSA eligible
- Typical results in 2-3 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting required and timing is flexible. The drugs procainamide and hydralazine can induce anti-DNA and antihistone antibodies, so note any medications when reviewing results.
Video consult with your Care Team
A 1:1 call to discuss your health.
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What this test is for
Double-stranded DNA antibodies are autoantibodies directed against the body's own genetic material, and they are among the most specific markers for systemic lupus erythematosus (SLE). They appear in roughly 80 to 90 percent of lupus cases and are far less common in healthy people, which is why a positive result carries weight, though it is not by itself sufficient to diagnose lupus. Levels correlate particularly well with lupus nephritis activity, so the test is also used to follow disease and gauge response to treatment. Lower-level positives can also show up in other rheumatic conditions and in chronic active hepatitis, infectious mononucleosis, and biliary cirrhosis, so the result is read against symptoms and other antibodies.
This is the focused dsDNA antibody test, typically ordered after a positive ANA to confirm and quantify lupus-associated antibodies. The broader ANA screen detects a wide range of antinuclear antibodies as a first-pass test, and the Autoimmune Panel adds complement levels alongside ANA; dsDNA is the more specific follow-up when lupus is the question.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 2-3 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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$9 /mo
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Without membership
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost — covering the lab and what it takes to run the service — never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9/mo, and you still pay the lab’s order fee. Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results post to your dashboard once your lab completes them, then a clinician reviews them and your full analysis and personalized action plan (with clear next steps) follow. Turnaround varies by test: specialty assays and at-home kits take longer, and each test shows its expected turnaround before you buy.
Do I need a doctor’s order?
No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.
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