Cortisone
The inactive partner to cortisol, used to assess the enzyme system that protects against mineralocorticoid-driven hypertension.
Consider this test if:
- Investigating hypertension with low potassium where aldosterone, deoxycorticosterone, and renin all come back low
- Working up suspected apparent mineralocorticoid excess or an 11β-HSD2 enzyme defect
- Heavy or chronic licorice or glycyrrhetinic-acid intake alongside unexplained high blood pressure
- Calculating a serum cortisol:cortisone ratio to localize the source of mineralocorticoid-type hypertension
- HSA/FSA eligible
- Typical results in 4-10 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting is required. Because cortisone tracks cortisol's daily rhythm, draw timing matters; collect at a consistent time and note it, especially if pairing with a cortisol measurement for the ratio. Recent licorice or glycyrrhetinic-acid ingestion can raise the cortisol:cortisone ratio and is worth disclosing.
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What this test is for
Cortisone is the inactive form of cortisol, produced when the enzyme 11β-hydroxysteroid dehydrogenase type 2 converts cortisol so it cannot activate the mineralocorticoid receptor. Measured in serum, it is most useful alongside cortisol to calculate the cortisol:cortisone (F/E) ratio, which reflects how well that protective enzyme is working. An elevated ratio points to impaired conversion and is the basis for diagnosing apparent mineralocorticoid excess, a rare inherited cause of childhood-onset hypertension with low potassium, low renin, and low aldosterone. A high ratio also appears with chronic kidney failure, heavy intake of licorice or glycyrrhetinic acid, and certain liver or bile-acid disorders.
This serum test gives a single point-in-time measurement. The separate 24-hour urine cortisone and free cortisol and cortisone urine collections capture metabolite output over a full day and are the forms used when an integrated daily ratio is needed.
- Specimen
- Serum or plasma
- Measures
- Mass concentration
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 4-10 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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