Cortisol, P.M.
Your evening cortisol low point, the part of the daily rhythm that flattens in Cushing's syndrome.
Consider this test if:
- Evaluating possible Cushing's syndrome, where evening cortisol fails to drop
- Symptoms of cortisol excess such as central weight gain, easy bruising, thinning skin, or high blood pressure
- Investigating fatigue, low blood pressure, or weight loss alongside an AM cortisol
- Mapping the morning-to-evening cortisol rhythm rather than a single reading
- HSA/FSA eligible
- Typical results in 1-2 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
Timing is the whole point: this is a late-day draw, so collect in the evening and note the exact collection time and date. High-dose biotin (vitamin B7) supplements can distort the result, so stop biotin at least 72 hours before the draw. Acute physical or emotional stress and recent illness raise cortisol and can cloud interpretation.
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What this test is for
Cortisol is the adrenal stress hormone that follows a strong daily rhythm: it peaks in the early morning and falls to its lowest point in the evening. This test measures the late-day (PM) trough, which is most useful for evaluating that rhythm rather than total output. A PM level that stays high instead of dropping is a classic sign of Cushing's syndrome (cortisol excess), while consistently low cortisol points toward adrenal insufficiency (Addison's disease). It pairs naturally with the AM (peak) measurement, since the difference between morning and evening levels is often more telling than either value alone.
This is the evening-trough version of the serum cortisol test. The standard Cortisol and Cortisol, AM tests capture a single timed level, the saliva and 24-hour urinary free cortisol tests measure unbound cortisol, and the ACTH stimulation test checks how the adrenal glands respond to a challenge.
- Specimen
- Serum or plasma
- Measures
- Mass concentration
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 1-2 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a physician's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate physician visit before purchasing.
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