Licorice Root Extract

Liquid Cortisol Support

BioMatrix Licorice Root Extract is the only clinician-directed liquid licorice formula standardized to deliver a consistent, quantified amount of glycyrrhizin per drop. Most licorice tinctures, capsules, and powders do not standardize glycyrrhizin content, making their cortisol effects unpredictable. BioMatrix provides precise control—each drop delivers 10.5 mg of Glycyrrhiza glabra extract yielding 0.84 mg of glycyrrhizin—allowing reproducible cortisol-preserving activity that clinicians can rely on when supporting low adrenal output, chronic stress patterns, or adrenal-fatigue–related symptoms.

This standardized extract helps raise and sustain active cortisol levels by slowing cortisol’s conversion into inactive cortisone. The result is more stable energy, clearer cognition, better stress tolerance, and improved mood steadiness. The glycerin-based liquid disperses efficiently under the tongue, providing consistent oral-mucosal absorption without the variability associated with capsules, powders, or non-standardized licorice products.

Licorice extract is also commonly combined with pregnenolone in adrenal-recovery protocols: pregnenolone supports upstream hormone pathways, while licorice preserves cortisol already in circulation, creating a coordinated approach for restoring adrenal resilience.

How Licorice Helps Raise Cortisol Levels

• Inhibits 11β-HSD2, the enzyme that converts cortisol into cortisone
• Extends cortisol’s physiologic half-life for sustained activity
• Supports patients with low morning energy, poor stress tolerance, or flattened diurnal rhythm
• Reinforces HPA-axis communication during chronic stress or recovery

This formula helps maintain healthy cortisol availability, support adrenal recovery, reinforce stress-response pathways, and promote vitality across multiple physiological systems. Its standardized potency and efficient oral mucosa dispersion provide clinicians with a controlled, dependable option for cortisol-enhancing adrenal support, especially when paired with pregnenolone.

Dosing Guidance: The label's Suggested Use is a starting point. For precision titration and pairing with adrenal protocols, consult BioMatrix for advanced use scenarios.