ANA Screen,IFA, Reflex Titer/Pattern,and Reflex to Multiplex 11 Ab Cascade
The gold-standard first screen for autoimmune rheumatic disease like lupus.
Consider this test if:
- Persistent joint pain, swelling, or morning stiffness alongside unexplained fatigue
- A facial (butterfly) rash, photosensitivity, or recurrent unexplained skin rashes
- Dry eyes and dry mouth, hair loss, or Raynaud-type color changes in the fingers
- A family history of lupus, scleroderma, Sjogren syndrome, or other autoimmune disease
- Working up a suspected connective tissue disease and wanting the standard first-line screen
- HSA/FSA eligible
- Results delivered to your dashboard · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Reflex testing
If your ANA screen is positive, the lab automatically reports the titer and staining pattern and then runs a cascade of disease-specific autoantibodies to help identify which autoimmune condition is most likely. All of this reflex testing is included at no additional cost.
Pre-test considerations
No fasting required and no special timing needed. This is a serum blood draw. Results reflect current antibody status, so no particular preparation changes the outcome.
Video consult with your Care Team
A 1:1 call to discuss your health.
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What this test is for
Antinuclear antibodies (ANA) are antibodies directed against components inside your own cell nuclei, and they are a hallmark of systemic autoimmune disease. This test uses immunofluorescence on HEp-2 cells, the method the American College of Rheumatology considers the gold standard for ANA screening because of its high sensitivity across conditions like systemic lupus erythematosus, Sjogren syndrome, systemic sclerosis (scleroderma), mixed connective tissue disease, and inflammatory myositis. It is commonly ordered when investigating clusters such as joint pain and swelling, unexplained fatigue, persistent rashes (including a facial butterfly rash), dry eyes and mouth, hair loss, or sun sensitivity. A positive ANA is not a diagnosis on its own: ANA appears in many healthy people and in other conditions, which is why titer, staining pattern, and specific autoantibodies are used to sharpen the picture. A negative result is genuinely useful because most clinically important autoantibodies are also negative when the ANA screen is negative.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Fast, dashboard-delivered results
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
cancel anytime
Without membership
$0
pay as you go
At-cost pricing on labs, scans, and more
Priority turnaround on your results
On-demand clinician consults when you need guidance
Personalized action plans across supplements, exercise, nutrition, and sleep
AI health coaching to help you act on your results
Year-round medical support, with in-chat clinician escalation
All your health records in one personal vault, with trends and biological age tracking
Early access to new diagnostics and product releases
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost — covering the lab and what it takes to run the service — never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9/mo, and you still pay the lab’s order fee. Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results post to your dashboard once your lab completes them, then a clinician reviews them and your full analysis and personalized action plan (with clear next steps) follow. Turnaround varies by test: specialty assays and at-home kits take longer, and each test shows its expected turnaround before you buy.
Do I need a doctor’s order?
No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.
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