4q25 Atrial Fibrillation Risk Genotype
Two inherited variants that raise the lifetime odds of atrial fibrillation and cardioembolic stroke.
Consider this test if:
- Atrial fibrillation or early cardioembolic stroke runs in your family
- Palpitations, irregular pulse, or unexplained breathlessness you are working up with a clinician
- Building a cardiovascular risk baseline alongside blood pressure and lipids
- Want to know whether to prioritize rhythm monitoring and modifiable-risk control
- HSA/FSA eligible
- Results delivered to your dashboard · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting or special timing required. This is a genotype, so the result does not change with time of day, recent meals, or medications. A single draw is definitive for life.
Video consult with your Care Team
A 1:1 call to discuss your health.
What members say on Trustpilot
What this test is for
The 4q25 region near the PITX2 gene holds the strongest common genetic signals for atrial fibrillation, the most common sustained heart rhythm disorder. This test reads two well-studied variants, rs2200733 and rs10033464, that are consistently associated with higher odds of AF and the cardioembolic strokes that can follow when the heart's upper chambers quiver instead of beating cleanly. Carrying a risk allele raises baseline odds; it does not mean you will develop AF, since age, blood pressure, alcohol, sleep apnea, and structural heart disease all weigh heavily on actual risk. Because genotype is fixed for life, a single test settles your status and adds inherited context to symptoms like palpitations, unexplained breathlessness, or fatigue with exertion, especially when AF or early stroke runs in the family. A high-risk result is a reason to be more vigilant about rhythm monitoring and to control the modifiable drivers, not a diagnosis on its own.
Biomarkers tested
Includes 4 biomarkers
- Specimen
- Blood or tissue
- Method
- Molecular (genetic)
- Measures
- Genotype
- Specimen
- Blood or tissue
- Method
- Molecular (genetic)
- Measures
- Genotype
- Measures
- Interpretation
- Measures
- Type
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Fast, dashboard-delivered results
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
cancel anytime
Without membership
$0
pay as you go
At-cost pricing on labs, scans, and more
Priority turnaround on your results
On-demand clinician consults when you need guidance
Personalized action plans across supplements, exercise, nutrition, and sleep
AI health coaching to help you act on your results
Year-round medical support, with in-chat clinician escalation
All your health records in one personal vault, with trends and biological age tracking
Early access to new diagnostics and product releases
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost — covering the lab and what it takes to run the service — never a profit on the test itself; Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9/mo, and you still pay the lab’s order fee. Prices are itemized before you pay, with no hidden fees.
Where do I get tested?
Choose a partner lab (Quest, Labcorp, or BioReference) at checkout. If your cart spans multiple tests, we consolidate the whole order onto a single lab so you only make one visit.
Is this eligible for HSA/FSA?
Yes. This test is HSA/FSA eligible, and you can pay with your HSA/FSA card at checkout.
When will I get my results?
Your results post to your dashboard once your lab completes them, then a clinician reviews them and your full analysis and personalized action plan (with clear next steps) follow. Turnaround varies by test: specialty assays and at-home kits take longer, and each test shows its expected turnaround before you buy.
Do I need a doctor’s order?
No. Mito provides the lab order for you, so you can book and get tested without a separate doctor visit.
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