MTHFR Mutation Genotype
An inherited variant in the enzyme that processes folate and regulates homocysteine.
Consider this test if:
- Elevated homocysteine on a blood test and you want to know whether genetics is contributing
- A family history of MTHFR variants or homocysteine-related concerns
- Planning or undergoing folate-dependent chemotherapy such as methotrexate
- Curious about your folate-processing genetics as a one-time baseline
- HSA/FSA eligible
- Typical results in 6-10 days · Reviewed by a real clinician
- Drawn at a CLIA/CAP-accredited lab near you ·
Pre-test considerations
No fasting or special preparation is needed. This is a genetic test, so the result is fixed for life and never needs repeating. If you also want to know your actual homocysteine level, which is the marker that shows whether the genotype is having any functional effect, that requires a separate blood test.
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A 1:1 call to discuss your health.
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What this test is for
MTHFR is the gene encoding methylenetetrahydrofolate reductase, the enzyme that converts folate into the active form used to clear homocysteine from the blood. This test identifies the two common variants, C677T and A1298C, that reduce enzyme activity and can raise homocysteine, particularly when folate intake is low. The genotype is a risk factor, not a diagnosis: these variants do not independently raise risk of homocysteine-related conditions unless homocysteine is actually elevated, so measuring total plasma homocysteine is the more useful functional marker. The one situation where the genotype directly informs care is folate-dependent chemotherapy such as methotrexate, where sharing your result with the prescribing physician matters. Major guidelines do not recommend testing these variants to evaluate clotting or pregnancy risk, given limited evidence of clinical utility.
- Specimen
- Blood or tissue
- Method
- Molecular (genetic)
- Measures
- Identity
What you'll learn
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Insights that connect the dots. A clinician reads your whole picture, not one result in isolation, connecting family history, past results, and lifestyle into clear next steps.
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Your personalized action plan. Nutrition, supplements, and training in one clinician-reviewed protocol, updated as your results change.
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Track your trends. Upload results from any lab and see each biomarker trend over time, so you know what is working.
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Never miss a recheck. Mito tells you what is worth retesting and when, then reminds you so nothing slips.
What to expect
- 1 Book instantly
Click, book, done. Choose a convenient lab location near you. Transparent, up-front pricing.
- 2 Quick lab visit
Testing to fit your busy schedule, usually 15 minutes or less. Walk-in and appointments available.
- 3 Typical results in 6-10 days
Your results post straight to your dashboard as soon as the lab completes them.
- 4 Expert guidance
Included with Mito membership. A clinician reviews your results and your personalized action plan follows, with clear next steps.
Everything your health needs,
in one membership
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Every test at our cost
Members pay our cost on every test, with lab fees passed straight through. The full receipt is itemized, never padded.
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Continuous tracking, all in one place
Upload past labs and watch your trends over time. Every marker and visit lives in one longitudinal record, so all your care stays together.
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Year-round clinician support
Text anytime and get clinician-reviewed answers. When you want to go deeper, 1:1 consultations are available at affordable rates.
All for $9/month
Order any test or consult without joining. For $9/month, members unlock member prices, trend tracking, and year-round clinician guidance.
Mito Membership
$9 /mo
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Without membership
$0
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Priority turnaround on your results
On-demand clinician consults when you need guidance
Personalized action plans across supplements, exercise, nutrition, and sleep
AI health coaching to help you act on your results
Year-round medical support, with in-chat clinician escalation
All your health records in one personal vault, with trends and biological age tracking
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Frequently asked questions
View all FAQsHow does pricing work?
Every test shows the member price next to the standard non-member price, so you can see what membership saves you. The member price is our cost, covering the lab and what it takes to run the service. It is never a profit on the test itself. Mito makes its money on the $9 membership, not on marking up your tests. Membership is $9 per month, and any applicable lab order or draw fee is itemized before you pay.
Where do I get tested?
Choose an available partner lab at checkout. If your cart contains multiple blood tests, Mito helps consolidate the eligible tests at one lab when possible. At-home kits and scans follow the collection or appointment process shown on their product page.
Is this eligible for HSA/FSA?
Yes. Eligible tests can be paid for with an HSA or FSA card at checkout.
When will I get my results?
Your results appear in your Mito dashboard after the laboratory completes processing. A clinician then reviews them before your analysis and personalized action plan are finalized. Timing varies by test, and specialty assays and at-home kits may take longer.
Do I need a doctor's order?
No. Mito provides the laboratory order when one is required, so you do not need to arrange a separate doctor visit before purchasing.
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