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Mito Health: Helping you live healthier, longer.

In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.

Mito Health: Helping you live healthier, longer.

In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.

Apr 15, 2025

HOMA-IR vs Estimated Average Glucose (eAG): Key Differences Explained

Compare HOMA-IR and Estimated Average Glucose (eAG) to learn which marker is more relevant for health assessment.

Introduction

HOMA-IR and Estimated Average Glucose (eAG) are essential biomarkers used to evaluate kidney function and overall metabolic health.

What Is HOMA-IR?

HOMA-IR helps assess the body’s ability to filter waste and maintain fluid balance.

What Is Estimated Average Glucose (eAG)?

Estimated Average Glucose (eAG) gives clinicians a ratio-based insight, often improving diagnostic accuracy in conjunction with HOMA-IR.

Comparison Table

Feature

HOMA-IR

ESTIMATED-AVERAGE-GLUCOSE-EAG

Primary Function

HOMA-IR detects or regulates processes related to inflammation, immunity, or metabolism.

ESTIMATED-AVERAGE-GLUCOSE-EAG plays a role in monitoring or responding to chronic or acute physiological changes.

Diagnostic Relevance

Used to evaluate conditions linked to elevated homa-ir levels such as infections or autoimmune disorders.

Helps assess disorders associated with abnormal estimated-average-glucose-eag concentrations.

Speed of Response

Responds rapidly to changes in health status or inflammation.

May rise or fall over a longer period.

Specificity

HOMA-IR offers relatively specific insight into related disease activity.

ESTIMATED-AVERAGE-GLUCOSE-EAG may be influenced by multiple unrelated conditions.

Clinical Use

Commonly ordered to guide treatment plans involving homa-ir pathways.

Used in clinical decision-making where estimated-average-glucose-eag patterns are relevant.

Measurement Units

Varies depending on assay (e.g., mg/L, ng/mL).

Also varies by lab method and clinical context.

Normal Range

Reference range depends on lab standards and population norms.

Interpretation requires context from other biomarkers.

Best Use Case

Effective when monitoring specific inflammation or disease progression via HOMA-IR.

Useful as part of a broader diagnostic panel involving ESTIMATED-AVERAGE-GLUCOSE-EAG.

What They Tell You

HOMA-IR provides foundational insight, while Estimated Average Glucose (eAG) enhances interpretation when both markers are tested together.

Clinical Use Cases

Doctors may order both tests when investigating causes of fatigue, swelling, or changes in urine output.

Which One Should You Get?

Often, both are tested together to interpret kidney function more precisely, especially in hospitalized or chronic care patients.

Can They Be Used Together?

Yes. Combined interpretation offers more context and accuracy in diagnosing renal and systemic conditions.

When to See a Doctor

If either HOMA-IR or Estimated Average Glucose (eAG) shows abnormal trends, especially with symptoms, follow up with a nephrologist or primary care provider.

FAQs

  • Does diet affect the results? Yes, high protein intake or dehydration can shift values.

  • Can I rely on just one? The ratio (Estimated Average Glucose (eAG)) is only meaningful when HOMA-IR and BUN are both measured.

  • Are these tests routine? Yes, especially for those with risk factors like diabetes or high blood pressure.

Optional Value-Add

  • In Seniors: These values change with age and muscle mass decline.

  • In Women: Hormonal cycles and hydration status may influence interpretation.

  • In Athletes: High protein intake or muscle turnover can affect levels.

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What would cost you $15,000? $399 with Mito.

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What's included

Core Panel - Comprehensive lab test covering 100+ biomarkers

Clinician reviewed insights and action plan

1:1 consultation with a real clinician

Upload past lab reports for lifetime tracking

Dedicated 1:1 health coaching

Duo Bundle (For 2)

Most popular

$798

$760

5% off

Individual

$399

What would cost you $15,000? $399 with Mito.

No hidden fees. No subscription traps. Just real care.

What's included

Core Panel - Comprehensive lab test covering 100+ biomarkers

Clinician reviewed insights and action plan

1:1 consultation with a real clinician

Upload past lab reports for lifetime tracking

Dedicated 1:1 health coaching

Duo Bundle (For 2)

Most popular

$798

$760

5% off

Individual

$399

What would cost you $15,000? $399 with Mito.

No hidden fees. No subscription traps. Just real care.

What's included

Core Panel - Comprehensive lab test covering 100+ biomarkers

Clinician reviewed insights and action plan

1:1 consultation with a real clinician

Upload past lab reports for lifetime tracking

Dedicated 1:1 health coaching

Duo Bundle (For 2)

Most popular

$798

$760

5% off

Individual

$399

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The information provided by Mito Health is for improving your overall health and wellness only and is not intended to provide medical advice, diagnosis, or treatment. We engage the services of partner clinics authorised to order the tests and to receive your blood test results prior to making Mito Health analytics and recommendations available to you. These interactions are not intended to create, nor do they create, a doctor-patient relationship. You should seek the advice of a doctor or other qualified health provider with whom you have such a relationship if you are experiencing any symptoms of, or believe you may have, any medical or psychiatric condition. You should not ignore professional medical advice or delay in seeking it because of Mito Health recommendations or analysis. This service should not be used for medical diagnosis or treatment. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your clinician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your clinician or other qualified health provider.

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The information provided by Mito Health is for improving your overall health and wellness only and is not intended to provide medical advice, diagnosis, or treatment. We engage the services of partner clinics authorised to order the tests and to receive your blood test results prior to making Mito Health analytics and recommendations available to you. These interactions are not intended to create, nor do they create, a doctor-patient relationship. You should seek the advice of a doctor or other qualified health provider with whom you have such a relationship if you are experiencing any symptoms of, or believe you may have, any medical or psychiatric condition. You should not ignore professional medical advice or delay in seeking it because of Mito Health recommendations or analysis. This service should not be used for medical diagnosis or treatment. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your clinician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your clinician or other qualified health provider.

© 2025 Mito Health Inc.

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The information provided by Mito Health is for improving your overall health and wellness only and is not intended to provide medical advice, diagnosis, or treatment. We engage the services of partner clinics authorised to order the tests and to receive your blood test results prior to making Mito Health analytics and recommendations available to you. These interactions are not intended to create, nor do they create, a doctor-patient relationship. You should seek the advice of a doctor or other qualified health provider with whom you have such a relationship if you are experiencing any symptoms of, or believe you may have, any medical or psychiatric condition. You should not ignore professional medical advice or delay in seeking it because of Mito Health recommendations or analysis. This service should not be used for medical diagnosis or treatment. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your clinician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your clinician or other qualified health provider.

© 2025 Mito Health Inc.

Company

Inquire

Join our newsletter

The information provided by Mito Health is for improving your overall health and wellness only and is not intended to provide medical advice, diagnosis, or treatment. We engage the services of partner clinics authorised to order the tests and to receive your blood test results prior to making Mito Health analytics and recommendations available to you. These interactions are not intended to create, nor do they create, a doctor-patient relationship. You should seek the advice of a doctor or other qualified health provider with whom you have such a relationship if you are experiencing any symptoms of, or believe you may have, any medical or psychiatric condition. You should not ignore professional medical advice or delay in seeking it because of Mito Health recommendations or analysis. This service should not be used for medical diagnosis or treatment. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your clinician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your clinician or other qualified health provider.

© 2025 Mito Health Inc.