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How to Raise Cortisol Naturally: 7 Evidence-Based Methods for Low Cortisol
Learn how to raise cortisol levels naturally for adrenal fatigue, chronic fatigue, and low morning cortisol. Evidence-based strategies using adaptogens, nutrition, sleep...

Written by
Mito Health

How to Raise Cortisol Naturally - 7 Evidence-Based Methods for Low Cortisol
Quick Summary
Learn how to raise cortisol levels naturally for adrenal fatigue, chronic fatigue, and low morning cortisol. Evidence-based strategies using adaptogens, nutrition, sleep...
You wake up exhausted-no matter how much sleep you get. Your blood pressure is low, you crave salt constantly, and standing up makes you dizzy. Stressful situations that used to energize you now leave you feeling completely depleted.
Your doctor tests your cortisol and says it's "on the low side" but not low enough for Addison's disease.
What your doctor might not mention: cortisol isn't just a "stress hormone"-it's your body's primary energy regulator. It mobilizes glucose, maintains blood pressure, regulates inflammation, and coordinates your circadian rhythm. When cortisol is chronically low (adrenal insufficiency or "adrenal fatigue"), you experience debilitating fatigue, brain fog, low blood pressure, and an inability to handle stress.
What most people don't realize is that targeted cortisol optimization can help. While severe adrenal insufficiency (Addison's disease) requires medical treatment, functional low cortisol-often called "adrenal fatigue" or HPA axis dysfunction-can often be improved with nutrition, adaptogens, sleep optimization, and lifestyle interventions. Let's break down the 7 most effective methods-optimize from within.
What Is Low Cortisol?
Cortisol is produced by your adrenal glands in response to signals from the pituitary (ACTH) and hypothalamus (CRH). It follows a circadian rhythm:
Morning peak: Cortisol should be highest 30-60 minutes after waking (cortisol awakening response)
Gradual decline: Throughout the day
Lowest point: Midnight to 3 AM
Optimal cortisol levels (4-point salivary test):
Morning (7-9 AM): 13-24 nmol/L (awakening response)
Noon: 5-10 nmol/L
Evening (4-6 PM): 3-8 nmol/L
Bedtime: 1-4 nmol/L
Low cortisol is defined as:
Morning cortisol <13 nmol/L (waking sample)
Flattened cortisol curve (low morning, minimal decline throughout day)
Want to assess your cortisol rhythm? Our 4-point salivary cortisol test measures your levels throughout the day-capturing your unique pattern. Data-driven insights for HPA axis optimization.
Types of low cortisol:
Primary adrenal insufficiency (Addison's disease): Adrenal glands cannot produce cortisol-requires medical treatment with hydrocortisone
Secondary adrenal insufficiency: Pituitary doesn't produce enough ACTH-often due to long-term steroid use
Functional adrenal insufficiency ("adrenal fatigue"): HPA axis dysfunction, stress-induced cortisol depletion-responds to natural interventions
The reality is that "adrenal fatigue" is controversial in conventional medicine, but research shows HPA axis dysfunction is real. Studies find that chronic stress, inflammation, and poor sleep can suppress cortisol production and blunt the cortisol awakening response [1]. when you address the root causes.
Track Your Cortisol Levels
Mito Health tests 100+ biomarkers including 4-point salivary cortisol, DHEA-S, and stress markers with physician-guided protocols to help you optimize energy, stress resilience, and HPA axis function. Our comprehensive panels provide personalized interpretation to identify adrenal dysfunction early.
Why Does Low Cortisol Happen?
Root causes of low cortisol:
1. HPA Axis Dysregulation (Chronic Stress Burnout)
After prolonged periods of high stress (months to years), the hypothalamic-pituitary-adrenal (HPA) axis can become dysregulated. Initial stress elevates cortisol, but eventually, the system "burns out"-cortisol production drops, ACTH sensitivity decreases, and you enter a state of chronic low cortisol [2].
Common triggers:
Chronic work stress, caregiving, financial strain
Sleep deprivation (blunts morning cortisol by 20-50%)
Chronic illness or inflammation
Psychological trauma or PTSD
2. Autoimmune Destruction of Adrenal Glands (Addison's Disease)
In Addison's disease, the immune system attacks adrenal tissue, destroying cortisol-producing cells. This is a serious medical condition requiring lifelong hormone replacement. Symptoms include extreme fatigue, low blood pressure, hyperpigmentation (darkening skin), and salt cravings [3].
Testing:
ACTH stimulation test (cortisol doesn't rise after ACTH injection)
Adrenal antibodies (21-hydroxylase antibodies)
Serum cortisol <5 mcg/dL (morning) is diagnostic
3. Chronic Inflammation and Cytokine Effects
Inflammatory cytokines (IL-6, TNF-alpha) can suppress HPA axis function. Chronic inflammatory conditions like autoimmune diseases, gut dysbiosis, and obesity can blunt cortisol production and reduce cortisol receptor sensitivity [4].
4. Nutrient Deficiencies (Vitamin C, B5, Magnesium)
Cortisol synthesis requires specific nutrients:
Vitamin C: Adrenal glands have the highest concentration of vitamin C in the body-used in cortisol synthesis
Pantothenic acid (B5): Critical for steroid hormone production
Magnesium: Cofactor for HPA axis signaling
Cholesterol: Precursor to all steroid hormones (cortisol, testosterone, estrogen)
Deficiency in these nutrients can impair cortisol production [5].
5. Long-Term Steroid Use (Suppression of Natural Production)
Taking prednisone, dexamethasone, or other corticosteroids for >2 weeks suppresses natural cortisol production. When you stop, your adrenal glands may take months to recover-this is called secondary adrenal insufficiency. Tapering steroids slowly is critical [6].
6. Poor Sleep Quality and Circadian Disruption
Cortisol production is tightly linked to your circadian rhythm. Night shift work, jet lag, blue light exposure at night, and irregular sleep schedules disrupt the cortisol awakening response and flatten the daily cortisol curve [7].
1. Optimize Sleep Timing and Quality (Restore Circadian Rhythm)
Why it works:
Cortisol production is regulated by your circadian clock. The cortisol awakening response (CAR)-a 50-100% spike in cortisol 30-60 minutes after waking-is critical for energy and alertness. Poor sleep quality, late bedtimes, and shift work suppress morning cortisol by 20-50% [8].
How to implement:
Sleep timing:
Consistent sleep/wake times: Go to bed 10-11 PM, wake 6-7 AM (align with natural circadian rhythm)
7.5-9 hours total: Cortisol production recovers during deep sleep
Morning light exposure:
Within 30 minutes of waking: Get 10-30 minutes of bright light (ideally sunlight)
Why: Light exposure triggers cortisol release via the suprachiasmatic nucleus (SCN)
Research: Morning light increases cortisol awakening response by 30-50% [9]
Evening routine:
Dim lights after sunset: Bright light after 8 PM suppresses next-day cortisol
Avoid blue light: Blue-blocking glasses 2 hours before bed
Cool bedroom: 66-68°F (18-20°C) optimizes cortisol rhythm
Sleep quality optimization:
Magnesium glycinate: 300-400 mg before bed (improves deep sleep)
Glycine: 3 grams before bed (enhances sleep quality, supports cortisol rhythm)
Ashwagandha: 300-600 mg (balances cortisol-lowers if high, raises if low via HPA axis modulation)
Evidence:
A study found that individuals with consistent sleep schedules (same bedtime plus or minus 30 min) had 40% higher morning cortisol compared to irregular sleepers [10].
2. Use Adaptogenic Herbs (Support HPA Axis Recovery)
Why it works:
Adaptogens modulate the HPA axis, helping it respond appropriately to stress. In low-cortisol states, they support adrenal function and increase cortisol production. In high-cortisol states, they reduce excess cortisol-they're "bidirectional" [11].
How to implement:
Licorice Root (Glycyrrhiza glabra):
Mechanism: Inhibits 11β-HSD2 enzyme, which breaks down cortisol-extends cortisol half-life by 30-50%
Dosage: 300-500 mg extract (20% glycyrrhizin) daily
Timing: Morning (to enhance cortisol awakening response)
Caution: Can raise blood pressure (inhibits aldosterone breakdown)-monitor BP, avoid if hypertensive
Duration: 4-8 weeks maximum, then take 2-week break
Evidence: Licorice root increased serum cortisol by 25% in individuals with low baseline cortisol [12].
Rhodiola Rosea:
Mechanism: Supports HPA axis regulation, enhances stress resilience, increases cortisol output under stress
Dosage: 200-400 mg (3% rosavins, 1% salidroside) daily
Timing: Morning or early afternoon (can be stimulating)
Best for: Fatigue, mental fog, stress-related low cortisol
Evidence: Rhodiola increased cortisol awakening response by 18% in chronic fatigue patients [13].
Cordyceps (Cordyceps militaris):
Mechanism: Supports adrenal cortex function, increases cortisol production, enhances ATP production
Dosage: 1,000-3,000 mg daily (or 500-1,000 mg extract)
Timing: Morning (energizing)
Best for: Athletes, physical fatigue, low stamina
Evidence: Cordyceps increased morning cortisol by 12-15% and improved exercise performance in athletes [14].
Ashwagandha (Withania somnifera):
Mechanism: Bidirectional-lowers high cortisol, supports low cortisol by normalizing HPA axis
Dosage: 300-600 mg (Sensoril or KSM-66 extract) daily
Timing: Morning or bedtime (depending on whether you need energy or stress reduction)
Best for: Generalized HPA axis dysfunction
Evidence: Ashwagandha normalized cortisol patterns in stressed adults (raised low morning cortisol by 10-15%) [15].
Protocol for low cortisol:
Weeks 1-4: Rhodiola (300 mg AM) + Ashwagandha (300 mg AM)
Weeks 5-8: Add licorice root (400 mg AM) if cortisol still low
Maintenance: Rhodiola + Ashwagandha long-term, cycle licorice 4 weeks on / 2 weeks off
3. Supplement with Vitamin C (Critical for Cortisol Synthesis)
Why it works:
The adrenal glands have the highest concentration of vitamin C in the body. Vitamin C is a cofactor for enzymes that convert cholesterol to cortisol. During stress or illness, vitamin C is rapidly depleted from adrenal tissue, impairing cortisol production [16].
How to implement:
Dosing:
1,000-2,000 mg daily (split doses: 500 mg 2-4x daily)
Higher doses during stress: 3,000-5,000 mg daily (spread throughout day)
Form: Ascorbic acid or sodium ascorbate (avoid if sensitive to acidity)
Timing:
With meals (reduces GI irritation)
Morning dose important (supports cortisol awakening response)
Food sources (as adjunct):
Bell peppers, kiwi, citrus fruits, strawberries, broccoli
Evidence:
A study in critically ill patients found that vitamin C supplementation (3,000 mg daily) increased cortisol production by 30% and shortened recovery time [17]. Another trial showed that vitamin C (1,000 mg daily) improved cortisol response to stress in adults with low baseline levels [18].
Expected timeline:
Improvements in energy and stress tolerance within 2-4 weeks.
4. Increase Sodium Intake (Support Blood Pressure and Aldosterone)
Why it works:
Low cortisol is often accompanied by low aldosterone (both produced by adrenal glands). Aldosterone regulates sodium and potassium balance. Without sufficient aldosterone, you lose sodium, leading to low blood pressure, dizziness, and salt cravings. Increasing sodium intake helps stabilize blood pressure and supports adrenal function [19].
How to implement:
Salt intake:
Add 1-2 teaspoons unrefined sea salt daily (Celtic sea salt, Himalayan pink salt)
Liberally salt meals (especially if you crave salt)
Salt in water: 1/4 teaspoon in 16 oz water in morning (adrenal cocktail)
Adrenal cocktail (supports cortisol and electrolyte balance):
Recipe: 4 oz orange juice (vitamin C) + 1/4 tsp sea salt + 1/4 tsp cream of tartar (potassium)
Timing: Morning and mid-afternoon (when cortisol should peak)
Benefits: Vitamin C + sodium + potassium supports adrenal function
Caution:
Check blood pressure regularly
If BP remains low (<100/60), consult doctor (may need fludrocortisone)
Evidence:
Increased sodium intake (2,500-3,500 mg daily) improved blood pressure and reduced fatigue symptoms in adrenal insufficiency patients not yet on medication [20].
5. Consume Adequate Protein and Healthy Fats (Support Hormone Production)
Why it works:
Cortisol is synthesized from cholesterol. Low-fat diets and inadequate protein reduce the building blocks needed for steroid hormone production. Protein provides amino acids (tyrosine, phenylalanine) for neurotransmitters that regulate HPA axis signaling [21].
How to implement:
Protein intake:
Target: 1.0-1.2 grams per pound body weight
Sources: Grass-fed meat, wild fish, eggs, poultry, Greek yogurt, cottage cheese
Timing: 30-40 grams at breakfast (supports cortisol awakening response)
Healthy fats:
Target: 30-35% of daily calories from fat
Sources: Egg yolks, grass-fed butter, ghee, avocado, olive oil, coconut oil, fatty fish
Cholesterol important: Eggs, organ meats (cortisol precursor)
Avoid:
Very low-calorie diets (<1,500 calories/day)-suppress cortisol production by 30-50%
Very low-carb diets long-term-can blunt cortisol awakening response (need some carbs for HPA axis)
Evidence:
A study found that increasing dietary fat from 20% to 40% of calories raised morning cortisol by 18% in individuals with low baseline levels [22].

Photo from Unsplash
6. Add Pantothenic Acid (Vitamin B5) and B-Complex
Why it works:
Pantothenic acid (vitamin B5) is critical for synthesis of coenzyme A, which is required for steroid hormone production in the adrenal glands. B vitamins also support cellular energy (ATP production), neurotransmitter synthesis, and stress resilience [23].
How to implement:
Pantothenic acid (B5):
Dosage: 500-1,000 mg daily (in divided doses)
Form: Calcium pantothenate or pantethine
Food sources: Organ meats (liver), mushrooms, avocado, eggs, legumes
B-Complex (comprehensive support):
Dosage: High-potency B-complex (B1, B2, B3, B5, B6, B12, folate)
B6: 25-50 mg (supports neurotransmitter production)
B12: 1,000 mcg (methylcobalamin for energy)
Folate: 400-800 mcg (methylfolate preferred)
Timing:
Take with breakfast (B vitamins can be energizing)
Evidence:
A trial in individuals with chronic fatigue found that pantothenic acid (1,000 mg daily) increased morning cortisol by 15% and improved fatigue scores by 30% over 8 weeks [24].
7. Strategic Exercise (Low-Intensity, Avoid Overtraining)
Why it works:
Exercise stimulates cortisol production-but the dose matters. Moderate exercise (30-60 min) raises cortisol acutely and improves HPA axis sensitivity long-term. However, high-intensity or prolonged exercise (>90 min) can further deplete cortisol in individuals with adrenal fatigue [25].
How to implement:
Best exercise types for low cortisol:
Walking: 30-60 minutes daily (gentle cortisol stimulation)
Yoga: Restorative or gentle flow (reduces stress, balances HPA axis)
Tai Chi or Qigong: Improves HPA axis regulation
Light strength training: 2-3x per week (20-30 min sessions)
Avoid:
HIIT or intense CrossFit-style training (further depletes cortisol)
Endurance exercise >90 minutes (marathon training, long cycling)
Fasted exercise (requires cortisol to mobilize energy-worsens fatigue)
Optimal timing:
Morning exercise (7-9 AM): Enhances cortisol awakening response
Outdoor exercise: Sunlight + movement = synergistic cortisol boost
Evidence:
A study found that 30 minutes of moderate walking (60-70% max HR) increased morning cortisol by 12% and improved HPA axis sensitivity in chronic fatigue patients, while high-intensity training worsened symptoms [26].
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Testing Protocols - When and What to Measure
Baseline testing (before starting interventions):
4-point salivary cortisol (waking, noon, evening, bedtime)-gold standard for HPA axis function
DHEA-S (dehydroepiandrosterone sulfate)-adrenal reserve marker
ACTH stimulation test (if suspected Addison's-cortisol should rise after synthetic ACTH)
Serum cortisol (morning, 8 AM)-quick screen but less accurate than saliva
Vitamin C (serum or leukocyte)
Vitamin B5 (pantothenic acid, whole blood)
Electrolytes (sodium, potassium-check for hyponatremia)
Blood pressure (standing and lying-check for orthostatic hypotension)
Follow-up testing:
4-6 weeks: Repeat 4-point salivary cortisol (assess early response)
12 weeks: Full retest (assess optimization)
6 months: Maintenance testing
Optimal targets:
Morning cortisol: 13-24 nmol/L (salivary) or 10-20 mcg/dL (serum)
Cortisol awakening response: 50-100% increase from waking to 30 min post-wake
Total daily output: 40-60 nmol/L (sum of 4-point test)
DHEA-S: 200-400 mcg/dL (men), 100-300 mcg/dL (women)
Severe Adrenal Insufficiency (Addison's Disease)
Goal: Medical treatment with hydrocortisone + natural support
Medical:
Hydrocortisone: 15-25 mg daily (split doses: AM, noon, PM)-prescribed by endocrinologist
Fludrocortisone: 0.05-0.2 mg daily (aldosterone replacement)
Natural adjuncts:
Vitamin C: 1,000-2,000 mg daily
Sodium: 3,000-5,000 mg daily (liberal salt intake)
Adrenal cocktail: 2x daily
Adaptogen support: Rhodiola (200 mg AM), Ashwagandha (300 mg PM)
Critical: Do not attempt to replace medical treatment with natural methods. Addison's is life-threatening without hormone replacement.
Moderate Adrenal Insufficiency (Functional, Morning Cortisol 8-13 nmol/L)
Goal: Raise morning cortisol to >13 nmol/L, improve energy within 4-8 weeks
Sleep optimization: Consistent 10:30 PM bedtime, 7-9 hours, morning light exposure
Licorice root: 400 mg AM (monitor BP)
Rhodiola: 300-400 mg AM
Vitamin C: 2,000 mg daily (split doses)
Pantothenic acid: 500 mg 2x daily
Adrenal cocktail: Morning and mid-afternoon
Sodium: 2,500-3,500 mg daily
Protein: 1.0 g/lb body weight, 30-40g at breakfast
Healthy fats: 35% of calories
Exercise: 30 min walking daily (morning)
Retest: 6-8 weeks
Mild Adrenal Insufficiency (Morning Cortisol 10-13 nmol/L, Flattened Curve)
Goal: Optimize cortisol rhythm, improve resilience to stress
Sleep timing: Consistent schedule, morning light
Rhodiola: 200-300 mg AM
Ashwagandha: 300 mg AM (HPA axis balancing)
Vitamin C: 1,000 mg daily
B-Complex: High-potency daily
Adrenal cocktail: Morning
Protein: 30g at breakfast
Exercise: Moderate walking, yoga, avoid overtraining
Retest: 8-12 weeks
Recovery from Long-Term Steroid Use (Secondary Adrenal Insufficiency)
Goal: Gradually restore natural cortisol production as steroids taper
Work with doctor: Slow taper (reduce prednisone by 1-2.5 mg every 1-2 weeks)
Vitamin C: 2,000-3,000 mg daily
Pantothenic acid: 1,000 mg daily
Rhodiola: 300 mg AM
Licorice root: 300-500 mg AM (supports low cortisol during taper)
DHEA: 25-50 mg daily (if DHEA-S <100 mcg/dL)-consult doctor
Sleep: Critical-prioritize 8+ hours
Patience: Adrenal recovery can take 6-12 months post-taper
Monitoring: Test cortisol every 4-6 weeks during taper
Expected Timeline for Cortisol Recovery
Weeks 1-2:
Improved sleep quality (if using magnesium, ashwagandha)
Better stress tolerance
Reduced salt cravings
Weeks 4-6:
Increased morning energy (cortisol awakening response improving)
Better blood pressure stability
Reduced brain fog
Noticeable increase in resilience
Weeks 8-12:
Measurable increase in cortisol (4-point test shows improvement)
Sustained energy throughout day
Improved exercise tolerance
Less dizziness when standing
Months 3-6:
Full HPA axis recovery for most functional cases
Normal cortisol rhythm restored
Ability to handle stress without crashing
DHEA-S levels normalizing
When to Seek Medical Treatment
Natural approaches work best for:
Functional adrenal insufficiency ("adrenal fatigue")
HPA axis dysfunction from chronic stress
Recovery from short-term steroid use
Seek medical treatment immediately if:
Morning cortisol <5 mcg/dL (serum)
Symptoms of adrenal crisis: severe weakness, confusion, low blood pressure, nausea, vomiting
Weight loss, hyperpigmentation (darkening skin), severe salt cravings
Orthostatic hypotension (BP drops >20 mmHg when standing)
ACTH stimulation test confirms primary adrenal insufficiency
Addison's disease is a medical emergency-requires lifelong hydrocortisone replacement.
The Bottom Line
Raising cortisol naturally is possible for functional adrenal insufficiency and HPA axis dysfunction, but severe cases (Addison's disease) require medical treatment. The key is restoring circadian rhythm through sleep optimization and morning light, supporting adrenal function with vitamin C and B5, using adaptogens strategically (licorice, rhodiola, cordyceps), and ensuring adequate sodium, protein, and healthy fats.
Start with testing-4-point salivary cortisol is essential to understand your baseline and track progress. Most people with functional low cortisol see improvements in energy and stress tolerance within 4-6 weeks, with full HPA axis recovery in 3-6 months. Cortisol isn't the enemy-chronic imbalance is. Support your adrenal glands with the right nutrients, lifestyle, and adaptogens, and your body will restore its natural rhythm.
Key Takeaways
Optimal cortisol follows a rhythm: High in morning (8-20 mcg/dL), low at night (<2-3 mcg/dL)
MMA is functional deficiency: Serum cortisol <12 mcg/dL or blunted morning spike indicates dysfunction
Sleep is foundational: Proper circadian rhythm (early bed, sunlight morning) is non-negotiable
Adaptogens matter: Licorice, rhodiola, cordyceps support adrenal function without causing addiction
Nutritional support essential: Vitamin C (500-1,000 mg), B5 (500 mg), magnesium (400 mg), sodium (3-5g)
Test to track: 4-point salivary cortisol every 4-6 weeks; MMA should return to normal within 2-3 months
Timeline realistic: 4-6 weeks for energy improvement; 3-6 months for full HPA recovery
Medical Disclaimer
This article is for educational and informational purposes only and does not constitute medical advice. The information provided should not be used for diagnosing or treating a health condition. Always consult with your doctor or qualified healthcare provider before starting any new supplement protocol, making changes to your diet, or if you have questions about a medical condition.
Individual results may vary. The dosages and protocols discussed are evidence-based but should be personalized under medical supervision, especially if you have existing health conditions or take medications.
Track Your Progress
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References
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How to Raise Cortisol Naturally: 7 Evidence-Based Methods for Low Cortisol
Learn how to raise cortisol levels naturally for adrenal fatigue, chronic fatigue, and low morning cortisol. Evidence-based strategies using adaptogens, nutrition, sleep...

Written by
Mito Health

How to Raise Cortisol Naturally - 7 Evidence-Based Methods for Low Cortisol
Quick Summary
Learn how to raise cortisol levels naturally for adrenal fatigue, chronic fatigue, and low morning cortisol. Evidence-based strategies using adaptogens, nutrition, sleep...
You wake up exhausted-no matter how much sleep you get. Your blood pressure is low, you crave salt constantly, and standing up makes you dizzy. Stressful situations that used to energize you now leave you feeling completely depleted.
Your doctor tests your cortisol and says it's "on the low side" but not low enough for Addison's disease.
What your doctor might not mention: cortisol isn't just a "stress hormone"-it's your body's primary energy regulator. It mobilizes glucose, maintains blood pressure, regulates inflammation, and coordinates your circadian rhythm. When cortisol is chronically low (adrenal insufficiency or "adrenal fatigue"), you experience debilitating fatigue, brain fog, low blood pressure, and an inability to handle stress.
What most people don't realize is that targeted cortisol optimization can help. While severe adrenal insufficiency (Addison's disease) requires medical treatment, functional low cortisol-often called "adrenal fatigue" or HPA axis dysfunction-can often be improved with nutrition, adaptogens, sleep optimization, and lifestyle interventions. Let's break down the 7 most effective methods-optimize from within.
What Is Low Cortisol?
Cortisol is produced by your adrenal glands in response to signals from the pituitary (ACTH) and hypothalamus (CRH). It follows a circadian rhythm:
Morning peak: Cortisol should be highest 30-60 minutes after waking (cortisol awakening response)
Gradual decline: Throughout the day
Lowest point: Midnight to 3 AM
Optimal cortisol levels (4-point salivary test):
Morning (7-9 AM): 13-24 nmol/L (awakening response)
Noon: 5-10 nmol/L
Evening (4-6 PM): 3-8 nmol/L
Bedtime: 1-4 nmol/L
Low cortisol is defined as:
Morning cortisol <13 nmol/L (waking sample)
Flattened cortisol curve (low morning, minimal decline throughout day)
Want to assess your cortisol rhythm? Our 4-point salivary cortisol test measures your levels throughout the day-capturing your unique pattern. Data-driven insights for HPA axis optimization.
Types of low cortisol:
Primary adrenal insufficiency (Addison's disease): Adrenal glands cannot produce cortisol-requires medical treatment with hydrocortisone
Secondary adrenal insufficiency: Pituitary doesn't produce enough ACTH-often due to long-term steroid use
Functional adrenal insufficiency ("adrenal fatigue"): HPA axis dysfunction, stress-induced cortisol depletion-responds to natural interventions
The reality is that "adrenal fatigue" is controversial in conventional medicine, but research shows HPA axis dysfunction is real. Studies find that chronic stress, inflammation, and poor sleep can suppress cortisol production and blunt the cortisol awakening response [1]. when you address the root causes.
Track Your Cortisol Levels
Mito Health tests 100+ biomarkers including 4-point salivary cortisol, DHEA-S, and stress markers with physician-guided protocols to help you optimize energy, stress resilience, and HPA axis function. Our comprehensive panels provide personalized interpretation to identify adrenal dysfunction early.
Why Does Low Cortisol Happen?
Root causes of low cortisol:
1. HPA Axis Dysregulation (Chronic Stress Burnout)
After prolonged periods of high stress (months to years), the hypothalamic-pituitary-adrenal (HPA) axis can become dysregulated. Initial stress elevates cortisol, but eventually, the system "burns out"-cortisol production drops, ACTH sensitivity decreases, and you enter a state of chronic low cortisol [2].
Common triggers:
Chronic work stress, caregiving, financial strain
Sleep deprivation (blunts morning cortisol by 20-50%)
Chronic illness or inflammation
Psychological trauma or PTSD
2. Autoimmune Destruction of Adrenal Glands (Addison's Disease)
In Addison's disease, the immune system attacks adrenal tissue, destroying cortisol-producing cells. This is a serious medical condition requiring lifelong hormone replacement. Symptoms include extreme fatigue, low blood pressure, hyperpigmentation (darkening skin), and salt cravings [3].
Testing:
ACTH stimulation test (cortisol doesn't rise after ACTH injection)
Adrenal antibodies (21-hydroxylase antibodies)
Serum cortisol <5 mcg/dL (morning) is diagnostic
3. Chronic Inflammation and Cytokine Effects
Inflammatory cytokines (IL-6, TNF-alpha) can suppress HPA axis function. Chronic inflammatory conditions like autoimmune diseases, gut dysbiosis, and obesity can blunt cortisol production and reduce cortisol receptor sensitivity [4].
4. Nutrient Deficiencies (Vitamin C, B5, Magnesium)
Cortisol synthesis requires specific nutrients:
Vitamin C: Adrenal glands have the highest concentration of vitamin C in the body-used in cortisol synthesis
Pantothenic acid (B5): Critical for steroid hormone production
Magnesium: Cofactor for HPA axis signaling
Cholesterol: Precursor to all steroid hormones (cortisol, testosterone, estrogen)
Deficiency in these nutrients can impair cortisol production [5].
5. Long-Term Steroid Use (Suppression of Natural Production)
Taking prednisone, dexamethasone, or other corticosteroids for >2 weeks suppresses natural cortisol production. When you stop, your adrenal glands may take months to recover-this is called secondary adrenal insufficiency. Tapering steroids slowly is critical [6].
6. Poor Sleep Quality and Circadian Disruption
Cortisol production is tightly linked to your circadian rhythm. Night shift work, jet lag, blue light exposure at night, and irregular sleep schedules disrupt the cortisol awakening response and flatten the daily cortisol curve [7].
1. Optimize Sleep Timing and Quality (Restore Circadian Rhythm)
Why it works:
Cortisol production is regulated by your circadian clock. The cortisol awakening response (CAR)-a 50-100% spike in cortisol 30-60 minutes after waking-is critical for energy and alertness. Poor sleep quality, late bedtimes, and shift work suppress morning cortisol by 20-50% [8].
How to implement:
Sleep timing:
Consistent sleep/wake times: Go to bed 10-11 PM, wake 6-7 AM (align with natural circadian rhythm)
7.5-9 hours total: Cortisol production recovers during deep sleep
Morning light exposure:
Within 30 minutes of waking: Get 10-30 minutes of bright light (ideally sunlight)
Why: Light exposure triggers cortisol release via the suprachiasmatic nucleus (SCN)
Research: Morning light increases cortisol awakening response by 30-50% [9]
Evening routine:
Dim lights after sunset: Bright light after 8 PM suppresses next-day cortisol
Avoid blue light: Blue-blocking glasses 2 hours before bed
Cool bedroom: 66-68°F (18-20°C) optimizes cortisol rhythm
Sleep quality optimization:
Magnesium glycinate: 300-400 mg before bed (improves deep sleep)
Glycine: 3 grams before bed (enhances sleep quality, supports cortisol rhythm)
Ashwagandha: 300-600 mg (balances cortisol-lowers if high, raises if low via HPA axis modulation)
Evidence:
A study found that individuals with consistent sleep schedules (same bedtime plus or minus 30 min) had 40% higher morning cortisol compared to irregular sleepers [10].
2. Use Adaptogenic Herbs (Support HPA Axis Recovery)
Why it works:
Adaptogens modulate the HPA axis, helping it respond appropriately to stress. In low-cortisol states, they support adrenal function and increase cortisol production. In high-cortisol states, they reduce excess cortisol-they're "bidirectional" [11].
How to implement:
Licorice Root (Glycyrrhiza glabra):
Mechanism: Inhibits 11β-HSD2 enzyme, which breaks down cortisol-extends cortisol half-life by 30-50%
Dosage: 300-500 mg extract (20% glycyrrhizin) daily
Timing: Morning (to enhance cortisol awakening response)
Caution: Can raise blood pressure (inhibits aldosterone breakdown)-monitor BP, avoid if hypertensive
Duration: 4-8 weeks maximum, then take 2-week break
Evidence: Licorice root increased serum cortisol by 25% in individuals with low baseline cortisol [12].
Rhodiola Rosea:
Mechanism: Supports HPA axis regulation, enhances stress resilience, increases cortisol output under stress
Dosage: 200-400 mg (3% rosavins, 1% salidroside) daily
Timing: Morning or early afternoon (can be stimulating)
Best for: Fatigue, mental fog, stress-related low cortisol
Evidence: Rhodiola increased cortisol awakening response by 18% in chronic fatigue patients [13].
Cordyceps (Cordyceps militaris):
Mechanism: Supports adrenal cortex function, increases cortisol production, enhances ATP production
Dosage: 1,000-3,000 mg daily (or 500-1,000 mg extract)
Timing: Morning (energizing)
Best for: Athletes, physical fatigue, low stamina
Evidence: Cordyceps increased morning cortisol by 12-15% and improved exercise performance in athletes [14].
Ashwagandha (Withania somnifera):
Mechanism: Bidirectional-lowers high cortisol, supports low cortisol by normalizing HPA axis
Dosage: 300-600 mg (Sensoril or KSM-66 extract) daily
Timing: Morning or bedtime (depending on whether you need energy or stress reduction)
Best for: Generalized HPA axis dysfunction
Evidence: Ashwagandha normalized cortisol patterns in stressed adults (raised low morning cortisol by 10-15%) [15].
Protocol for low cortisol:
Weeks 1-4: Rhodiola (300 mg AM) + Ashwagandha (300 mg AM)
Weeks 5-8: Add licorice root (400 mg AM) if cortisol still low
Maintenance: Rhodiola + Ashwagandha long-term, cycle licorice 4 weeks on / 2 weeks off
3. Supplement with Vitamin C (Critical for Cortisol Synthesis)
Why it works:
The adrenal glands have the highest concentration of vitamin C in the body. Vitamin C is a cofactor for enzymes that convert cholesterol to cortisol. During stress or illness, vitamin C is rapidly depleted from adrenal tissue, impairing cortisol production [16].
How to implement:
Dosing:
1,000-2,000 mg daily (split doses: 500 mg 2-4x daily)
Higher doses during stress: 3,000-5,000 mg daily (spread throughout day)
Form: Ascorbic acid or sodium ascorbate (avoid if sensitive to acidity)
Timing:
With meals (reduces GI irritation)
Morning dose important (supports cortisol awakening response)
Food sources (as adjunct):
Bell peppers, kiwi, citrus fruits, strawberries, broccoli
Evidence:
A study in critically ill patients found that vitamin C supplementation (3,000 mg daily) increased cortisol production by 30% and shortened recovery time [17]. Another trial showed that vitamin C (1,000 mg daily) improved cortisol response to stress in adults with low baseline levels [18].
Expected timeline:
Improvements in energy and stress tolerance within 2-4 weeks.
4. Increase Sodium Intake (Support Blood Pressure and Aldosterone)
Why it works:
Low cortisol is often accompanied by low aldosterone (both produced by adrenal glands). Aldosterone regulates sodium and potassium balance. Without sufficient aldosterone, you lose sodium, leading to low blood pressure, dizziness, and salt cravings. Increasing sodium intake helps stabilize blood pressure and supports adrenal function [19].
How to implement:
Salt intake:
Add 1-2 teaspoons unrefined sea salt daily (Celtic sea salt, Himalayan pink salt)
Liberally salt meals (especially if you crave salt)
Salt in water: 1/4 teaspoon in 16 oz water in morning (adrenal cocktail)
Adrenal cocktail (supports cortisol and electrolyte balance):
Recipe: 4 oz orange juice (vitamin C) + 1/4 tsp sea salt + 1/4 tsp cream of tartar (potassium)
Timing: Morning and mid-afternoon (when cortisol should peak)
Benefits: Vitamin C + sodium + potassium supports adrenal function
Caution:
Check blood pressure regularly
If BP remains low (<100/60), consult doctor (may need fludrocortisone)
Evidence:
Increased sodium intake (2,500-3,500 mg daily) improved blood pressure and reduced fatigue symptoms in adrenal insufficiency patients not yet on medication [20].
5. Consume Adequate Protein and Healthy Fats (Support Hormone Production)
Why it works:
Cortisol is synthesized from cholesterol. Low-fat diets and inadequate protein reduce the building blocks needed for steroid hormone production. Protein provides amino acids (tyrosine, phenylalanine) for neurotransmitters that regulate HPA axis signaling [21].
How to implement:
Protein intake:
Target: 1.0-1.2 grams per pound body weight
Sources: Grass-fed meat, wild fish, eggs, poultry, Greek yogurt, cottage cheese
Timing: 30-40 grams at breakfast (supports cortisol awakening response)
Healthy fats:
Target: 30-35% of daily calories from fat
Sources: Egg yolks, grass-fed butter, ghee, avocado, olive oil, coconut oil, fatty fish
Cholesterol important: Eggs, organ meats (cortisol precursor)
Avoid:
Very low-calorie diets (<1,500 calories/day)-suppress cortisol production by 30-50%
Very low-carb diets long-term-can blunt cortisol awakening response (need some carbs for HPA axis)
Evidence:
A study found that increasing dietary fat from 20% to 40% of calories raised morning cortisol by 18% in individuals with low baseline levels [22].

Photo from Unsplash
6. Add Pantothenic Acid (Vitamin B5) and B-Complex
Why it works:
Pantothenic acid (vitamin B5) is critical for synthesis of coenzyme A, which is required for steroid hormone production in the adrenal glands. B vitamins also support cellular energy (ATP production), neurotransmitter synthesis, and stress resilience [23].
How to implement:
Pantothenic acid (B5):
Dosage: 500-1,000 mg daily (in divided doses)
Form: Calcium pantothenate or pantethine
Food sources: Organ meats (liver), mushrooms, avocado, eggs, legumes
B-Complex (comprehensive support):
Dosage: High-potency B-complex (B1, B2, B3, B5, B6, B12, folate)
B6: 25-50 mg (supports neurotransmitter production)
B12: 1,000 mcg (methylcobalamin for energy)
Folate: 400-800 mcg (methylfolate preferred)
Timing:
Take with breakfast (B vitamins can be energizing)
Evidence:
A trial in individuals with chronic fatigue found that pantothenic acid (1,000 mg daily) increased morning cortisol by 15% and improved fatigue scores by 30% over 8 weeks [24].
7. Strategic Exercise (Low-Intensity, Avoid Overtraining)
Why it works:
Exercise stimulates cortisol production-but the dose matters. Moderate exercise (30-60 min) raises cortisol acutely and improves HPA axis sensitivity long-term. However, high-intensity or prolonged exercise (>90 min) can further deplete cortisol in individuals with adrenal fatigue [25].
How to implement:
Best exercise types for low cortisol:
Walking: 30-60 minutes daily (gentle cortisol stimulation)
Yoga: Restorative or gentle flow (reduces stress, balances HPA axis)
Tai Chi or Qigong: Improves HPA axis regulation
Light strength training: 2-3x per week (20-30 min sessions)
Avoid:
HIIT or intense CrossFit-style training (further depletes cortisol)
Endurance exercise >90 minutes (marathon training, long cycling)
Fasted exercise (requires cortisol to mobilize energy-worsens fatigue)
Optimal timing:
Morning exercise (7-9 AM): Enhances cortisol awakening response
Outdoor exercise: Sunlight + movement = synergistic cortisol boost
Evidence:
A study found that 30 minutes of moderate walking (60-70% max HR) increased morning cortisol by 12% and improved HPA axis sensitivity in chronic fatigue patients, while high-intensity training worsened symptoms [26].
Get the Full Picture
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Testing Protocols - When and What to Measure
Baseline testing (before starting interventions):
4-point salivary cortisol (waking, noon, evening, bedtime)-gold standard for HPA axis function
DHEA-S (dehydroepiandrosterone sulfate)-adrenal reserve marker
ACTH stimulation test (if suspected Addison's-cortisol should rise after synthetic ACTH)
Serum cortisol (morning, 8 AM)-quick screen but less accurate than saliva
Vitamin C (serum or leukocyte)
Vitamin B5 (pantothenic acid, whole blood)
Electrolytes (sodium, potassium-check for hyponatremia)
Blood pressure (standing and lying-check for orthostatic hypotension)
Follow-up testing:
4-6 weeks: Repeat 4-point salivary cortisol (assess early response)
12 weeks: Full retest (assess optimization)
6 months: Maintenance testing
Optimal targets:
Morning cortisol: 13-24 nmol/L (salivary) or 10-20 mcg/dL (serum)
Cortisol awakening response: 50-100% increase from waking to 30 min post-wake
Total daily output: 40-60 nmol/L (sum of 4-point test)
DHEA-S: 200-400 mcg/dL (men), 100-300 mcg/dL (women)
Severe Adrenal Insufficiency (Addison's Disease)
Goal: Medical treatment with hydrocortisone + natural support
Medical:
Hydrocortisone: 15-25 mg daily (split doses: AM, noon, PM)-prescribed by endocrinologist
Fludrocortisone: 0.05-0.2 mg daily (aldosterone replacement)
Natural adjuncts:
Vitamin C: 1,000-2,000 mg daily
Sodium: 3,000-5,000 mg daily (liberal salt intake)
Adrenal cocktail: 2x daily
Adaptogen support: Rhodiola (200 mg AM), Ashwagandha (300 mg PM)
Critical: Do not attempt to replace medical treatment with natural methods. Addison's is life-threatening without hormone replacement.
Moderate Adrenal Insufficiency (Functional, Morning Cortisol 8-13 nmol/L)
Goal: Raise morning cortisol to >13 nmol/L, improve energy within 4-8 weeks
Sleep optimization: Consistent 10:30 PM bedtime, 7-9 hours, morning light exposure
Licorice root: 400 mg AM (monitor BP)
Rhodiola: 300-400 mg AM
Vitamin C: 2,000 mg daily (split doses)
Pantothenic acid: 500 mg 2x daily
Adrenal cocktail: Morning and mid-afternoon
Sodium: 2,500-3,500 mg daily
Protein: 1.0 g/lb body weight, 30-40g at breakfast
Healthy fats: 35% of calories
Exercise: 30 min walking daily (morning)
Retest: 6-8 weeks
Mild Adrenal Insufficiency (Morning Cortisol 10-13 nmol/L, Flattened Curve)
Goal: Optimize cortisol rhythm, improve resilience to stress
Sleep timing: Consistent schedule, morning light
Rhodiola: 200-300 mg AM
Ashwagandha: 300 mg AM (HPA axis balancing)
Vitamin C: 1,000 mg daily
B-Complex: High-potency daily
Adrenal cocktail: Morning
Protein: 30g at breakfast
Exercise: Moderate walking, yoga, avoid overtraining
Retest: 8-12 weeks
Recovery from Long-Term Steroid Use (Secondary Adrenal Insufficiency)
Goal: Gradually restore natural cortisol production as steroids taper
Work with doctor: Slow taper (reduce prednisone by 1-2.5 mg every 1-2 weeks)
Vitamin C: 2,000-3,000 mg daily
Pantothenic acid: 1,000 mg daily
Rhodiola: 300 mg AM
Licorice root: 300-500 mg AM (supports low cortisol during taper)
DHEA: 25-50 mg daily (if DHEA-S <100 mcg/dL)-consult doctor
Sleep: Critical-prioritize 8+ hours
Patience: Adrenal recovery can take 6-12 months post-taper
Monitoring: Test cortisol every 4-6 weeks during taper
Expected Timeline for Cortisol Recovery
Weeks 1-2:
Improved sleep quality (if using magnesium, ashwagandha)
Better stress tolerance
Reduced salt cravings
Weeks 4-6:
Increased morning energy (cortisol awakening response improving)
Better blood pressure stability
Reduced brain fog
Noticeable increase in resilience
Weeks 8-12:
Measurable increase in cortisol (4-point test shows improvement)
Sustained energy throughout day
Improved exercise tolerance
Less dizziness when standing
Months 3-6:
Full HPA axis recovery for most functional cases
Normal cortisol rhythm restored
Ability to handle stress without crashing
DHEA-S levels normalizing
When to Seek Medical Treatment
Natural approaches work best for:
Functional adrenal insufficiency ("adrenal fatigue")
HPA axis dysfunction from chronic stress
Recovery from short-term steroid use
Seek medical treatment immediately if:
Morning cortisol <5 mcg/dL (serum)
Symptoms of adrenal crisis: severe weakness, confusion, low blood pressure, nausea, vomiting
Weight loss, hyperpigmentation (darkening skin), severe salt cravings
Orthostatic hypotension (BP drops >20 mmHg when standing)
ACTH stimulation test confirms primary adrenal insufficiency
Addison's disease is a medical emergency-requires lifelong hydrocortisone replacement.
The Bottom Line
Raising cortisol naturally is possible for functional adrenal insufficiency and HPA axis dysfunction, but severe cases (Addison's disease) require medical treatment. The key is restoring circadian rhythm through sleep optimization and morning light, supporting adrenal function with vitamin C and B5, using adaptogens strategically (licorice, rhodiola, cordyceps), and ensuring adequate sodium, protein, and healthy fats.
Start with testing-4-point salivary cortisol is essential to understand your baseline and track progress. Most people with functional low cortisol see improvements in energy and stress tolerance within 4-6 weeks, with full HPA axis recovery in 3-6 months. Cortisol isn't the enemy-chronic imbalance is. Support your adrenal glands with the right nutrients, lifestyle, and adaptogens, and your body will restore its natural rhythm.
Key Takeaways
Optimal cortisol follows a rhythm: High in morning (8-20 mcg/dL), low at night (<2-3 mcg/dL)
MMA is functional deficiency: Serum cortisol <12 mcg/dL or blunted morning spike indicates dysfunction
Sleep is foundational: Proper circadian rhythm (early bed, sunlight morning) is non-negotiable
Adaptogens matter: Licorice, rhodiola, cordyceps support adrenal function without causing addiction
Nutritional support essential: Vitamin C (500-1,000 mg), B5 (500 mg), magnesium (400 mg), sodium (3-5g)
Test to track: 4-point salivary cortisol every 4-6 weeks; MMA should return to normal within 2-3 months
Timeline realistic: 4-6 weeks for energy improvement; 3-6 months for full HPA recovery
Medical Disclaimer
This article is for educational and informational purposes only and does not constitute medical advice. The information provided should not be used for diagnosing or treating a health condition. Always consult with your doctor or qualified healthcare provider before starting any new supplement protocol, making changes to your diet, or if you have questions about a medical condition.
Individual results may vary. The dosages and protocols discussed are evidence-based but should be personalized under medical supervision, especially if you have existing health conditions or take medications.
Track Your Progress
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References
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How to Raise Cortisol Naturally: 7 Evidence-Based Methods for Low Cortisol
Learn how to raise cortisol levels naturally for adrenal fatigue, chronic fatigue, and low morning cortisol. Evidence-based strategies using adaptogens, nutrition, sleep...

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Mito Health

How to Raise Cortisol Naturally - 7 Evidence-Based Methods for Low Cortisol
Quick Summary
Learn how to raise cortisol levels naturally for adrenal fatigue, chronic fatigue, and low morning cortisol. Evidence-based strategies using adaptogens, nutrition, sleep...
You wake up exhausted-no matter how much sleep you get. Your blood pressure is low, you crave salt constantly, and standing up makes you dizzy. Stressful situations that used to energize you now leave you feeling completely depleted.
Your doctor tests your cortisol and says it's "on the low side" but not low enough for Addison's disease.
What your doctor might not mention: cortisol isn't just a "stress hormone"-it's your body's primary energy regulator. It mobilizes glucose, maintains blood pressure, regulates inflammation, and coordinates your circadian rhythm. When cortisol is chronically low (adrenal insufficiency or "adrenal fatigue"), you experience debilitating fatigue, brain fog, low blood pressure, and an inability to handle stress.
What most people don't realize is that targeted cortisol optimization can help. While severe adrenal insufficiency (Addison's disease) requires medical treatment, functional low cortisol-often called "adrenal fatigue" or HPA axis dysfunction-can often be improved with nutrition, adaptogens, sleep optimization, and lifestyle interventions. Let's break down the 7 most effective methods-optimize from within.
What Is Low Cortisol?
Cortisol is produced by your adrenal glands in response to signals from the pituitary (ACTH) and hypothalamus (CRH). It follows a circadian rhythm:
Morning peak: Cortisol should be highest 30-60 minutes after waking (cortisol awakening response)
Gradual decline: Throughout the day
Lowest point: Midnight to 3 AM
Optimal cortisol levels (4-point salivary test):
Morning (7-9 AM): 13-24 nmol/L (awakening response)
Noon: 5-10 nmol/L
Evening (4-6 PM): 3-8 nmol/L
Bedtime: 1-4 nmol/L
Low cortisol is defined as:
Morning cortisol <13 nmol/L (waking sample)
Flattened cortisol curve (low morning, minimal decline throughout day)
Want to assess your cortisol rhythm? Our 4-point salivary cortisol test measures your levels throughout the day-capturing your unique pattern. Data-driven insights for HPA axis optimization.
Types of low cortisol:
Primary adrenal insufficiency (Addison's disease): Adrenal glands cannot produce cortisol-requires medical treatment with hydrocortisone
Secondary adrenal insufficiency: Pituitary doesn't produce enough ACTH-often due to long-term steroid use
Functional adrenal insufficiency ("adrenal fatigue"): HPA axis dysfunction, stress-induced cortisol depletion-responds to natural interventions
The reality is that "adrenal fatigue" is controversial in conventional medicine, but research shows HPA axis dysfunction is real. Studies find that chronic stress, inflammation, and poor sleep can suppress cortisol production and blunt the cortisol awakening response [1]. when you address the root causes.
Track Your Cortisol Levels
Mito Health tests 100+ biomarkers including 4-point salivary cortisol, DHEA-S, and stress markers with physician-guided protocols to help you optimize energy, stress resilience, and HPA axis function. Our comprehensive panels provide personalized interpretation to identify adrenal dysfunction early.
Why Does Low Cortisol Happen?
Root causes of low cortisol:
1. HPA Axis Dysregulation (Chronic Stress Burnout)
After prolonged periods of high stress (months to years), the hypothalamic-pituitary-adrenal (HPA) axis can become dysregulated. Initial stress elevates cortisol, but eventually, the system "burns out"-cortisol production drops, ACTH sensitivity decreases, and you enter a state of chronic low cortisol [2].
Common triggers:
Chronic work stress, caregiving, financial strain
Sleep deprivation (blunts morning cortisol by 20-50%)
Chronic illness or inflammation
Psychological trauma or PTSD
2. Autoimmune Destruction of Adrenal Glands (Addison's Disease)
In Addison's disease, the immune system attacks adrenal tissue, destroying cortisol-producing cells. This is a serious medical condition requiring lifelong hormone replacement. Symptoms include extreme fatigue, low blood pressure, hyperpigmentation (darkening skin), and salt cravings [3].
Testing:
ACTH stimulation test (cortisol doesn't rise after ACTH injection)
Adrenal antibodies (21-hydroxylase antibodies)
Serum cortisol <5 mcg/dL (morning) is diagnostic
3. Chronic Inflammation and Cytokine Effects
Inflammatory cytokines (IL-6, TNF-alpha) can suppress HPA axis function. Chronic inflammatory conditions like autoimmune diseases, gut dysbiosis, and obesity can blunt cortisol production and reduce cortisol receptor sensitivity [4].
4. Nutrient Deficiencies (Vitamin C, B5, Magnesium)
Cortisol synthesis requires specific nutrients:
Vitamin C: Adrenal glands have the highest concentration of vitamin C in the body-used in cortisol synthesis
Pantothenic acid (B5): Critical for steroid hormone production
Magnesium: Cofactor for HPA axis signaling
Cholesterol: Precursor to all steroid hormones (cortisol, testosterone, estrogen)
Deficiency in these nutrients can impair cortisol production [5].
5. Long-Term Steroid Use (Suppression of Natural Production)
Taking prednisone, dexamethasone, or other corticosteroids for >2 weeks suppresses natural cortisol production. When you stop, your adrenal glands may take months to recover-this is called secondary adrenal insufficiency. Tapering steroids slowly is critical [6].
6. Poor Sleep Quality and Circadian Disruption
Cortisol production is tightly linked to your circadian rhythm. Night shift work, jet lag, blue light exposure at night, and irregular sleep schedules disrupt the cortisol awakening response and flatten the daily cortisol curve [7].
1. Optimize Sleep Timing and Quality (Restore Circadian Rhythm)
Why it works:
Cortisol production is regulated by your circadian clock. The cortisol awakening response (CAR)-a 50-100% spike in cortisol 30-60 minutes after waking-is critical for energy and alertness. Poor sleep quality, late bedtimes, and shift work suppress morning cortisol by 20-50% [8].
How to implement:
Sleep timing:
Consistent sleep/wake times: Go to bed 10-11 PM, wake 6-7 AM (align with natural circadian rhythm)
7.5-9 hours total: Cortisol production recovers during deep sleep
Morning light exposure:
Within 30 minutes of waking: Get 10-30 minutes of bright light (ideally sunlight)
Why: Light exposure triggers cortisol release via the suprachiasmatic nucleus (SCN)
Research: Morning light increases cortisol awakening response by 30-50% [9]
Evening routine:
Dim lights after sunset: Bright light after 8 PM suppresses next-day cortisol
Avoid blue light: Blue-blocking glasses 2 hours before bed
Cool bedroom: 66-68°F (18-20°C) optimizes cortisol rhythm
Sleep quality optimization:
Magnesium glycinate: 300-400 mg before bed (improves deep sleep)
Glycine: 3 grams before bed (enhances sleep quality, supports cortisol rhythm)
Ashwagandha: 300-600 mg (balances cortisol-lowers if high, raises if low via HPA axis modulation)
Evidence:
A study found that individuals with consistent sleep schedules (same bedtime plus or minus 30 min) had 40% higher morning cortisol compared to irregular sleepers [10].
2. Use Adaptogenic Herbs (Support HPA Axis Recovery)
Why it works:
Adaptogens modulate the HPA axis, helping it respond appropriately to stress. In low-cortisol states, they support adrenal function and increase cortisol production. In high-cortisol states, they reduce excess cortisol-they're "bidirectional" [11].
How to implement:
Licorice Root (Glycyrrhiza glabra):
Mechanism: Inhibits 11β-HSD2 enzyme, which breaks down cortisol-extends cortisol half-life by 30-50%
Dosage: 300-500 mg extract (20% glycyrrhizin) daily
Timing: Morning (to enhance cortisol awakening response)
Caution: Can raise blood pressure (inhibits aldosterone breakdown)-monitor BP, avoid if hypertensive
Duration: 4-8 weeks maximum, then take 2-week break
Evidence: Licorice root increased serum cortisol by 25% in individuals with low baseline cortisol [12].
Rhodiola Rosea:
Mechanism: Supports HPA axis regulation, enhances stress resilience, increases cortisol output under stress
Dosage: 200-400 mg (3% rosavins, 1% salidroside) daily
Timing: Morning or early afternoon (can be stimulating)
Best for: Fatigue, mental fog, stress-related low cortisol
Evidence: Rhodiola increased cortisol awakening response by 18% in chronic fatigue patients [13].
Cordyceps (Cordyceps militaris):
Mechanism: Supports adrenal cortex function, increases cortisol production, enhances ATP production
Dosage: 1,000-3,000 mg daily (or 500-1,000 mg extract)
Timing: Morning (energizing)
Best for: Athletes, physical fatigue, low stamina
Evidence: Cordyceps increased morning cortisol by 12-15% and improved exercise performance in athletes [14].
Ashwagandha (Withania somnifera):
Mechanism: Bidirectional-lowers high cortisol, supports low cortisol by normalizing HPA axis
Dosage: 300-600 mg (Sensoril or KSM-66 extract) daily
Timing: Morning or bedtime (depending on whether you need energy or stress reduction)
Best for: Generalized HPA axis dysfunction
Evidence: Ashwagandha normalized cortisol patterns in stressed adults (raised low morning cortisol by 10-15%) [15].
Protocol for low cortisol:
Weeks 1-4: Rhodiola (300 mg AM) + Ashwagandha (300 mg AM)
Weeks 5-8: Add licorice root (400 mg AM) if cortisol still low
Maintenance: Rhodiola + Ashwagandha long-term, cycle licorice 4 weeks on / 2 weeks off
3. Supplement with Vitamin C (Critical for Cortisol Synthesis)
Why it works:
The adrenal glands have the highest concentration of vitamin C in the body. Vitamin C is a cofactor for enzymes that convert cholesterol to cortisol. During stress or illness, vitamin C is rapidly depleted from adrenal tissue, impairing cortisol production [16].
How to implement:
Dosing:
1,000-2,000 mg daily (split doses: 500 mg 2-4x daily)
Higher doses during stress: 3,000-5,000 mg daily (spread throughout day)
Form: Ascorbic acid or sodium ascorbate (avoid if sensitive to acidity)
Timing:
With meals (reduces GI irritation)
Morning dose important (supports cortisol awakening response)
Food sources (as adjunct):
Bell peppers, kiwi, citrus fruits, strawberries, broccoli
Evidence:
A study in critically ill patients found that vitamin C supplementation (3,000 mg daily) increased cortisol production by 30% and shortened recovery time [17]. Another trial showed that vitamin C (1,000 mg daily) improved cortisol response to stress in adults with low baseline levels [18].
Expected timeline:
Improvements in energy and stress tolerance within 2-4 weeks.
4. Increase Sodium Intake (Support Blood Pressure and Aldosterone)
Why it works:
Low cortisol is often accompanied by low aldosterone (both produced by adrenal glands). Aldosterone regulates sodium and potassium balance. Without sufficient aldosterone, you lose sodium, leading to low blood pressure, dizziness, and salt cravings. Increasing sodium intake helps stabilize blood pressure and supports adrenal function [19].
How to implement:
Salt intake:
Add 1-2 teaspoons unrefined sea salt daily (Celtic sea salt, Himalayan pink salt)
Liberally salt meals (especially if you crave salt)
Salt in water: 1/4 teaspoon in 16 oz water in morning (adrenal cocktail)
Adrenal cocktail (supports cortisol and electrolyte balance):
Recipe: 4 oz orange juice (vitamin C) + 1/4 tsp sea salt + 1/4 tsp cream of tartar (potassium)
Timing: Morning and mid-afternoon (when cortisol should peak)
Benefits: Vitamin C + sodium + potassium supports adrenal function
Caution:
Check blood pressure regularly
If BP remains low (<100/60), consult doctor (may need fludrocortisone)
Evidence:
Increased sodium intake (2,500-3,500 mg daily) improved blood pressure and reduced fatigue symptoms in adrenal insufficiency patients not yet on medication [20].
5. Consume Adequate Protein and Healthy Fats (Support Hormone Production)
Why it works:
Cortisol is synthesized from cholesterol. Low-fat diets and inadequate protein reduce the building blocks needed for steroid hormone production. Protein provides amino acids (tyrosine, phenylalanine) for neurotransmitters that regulate HPA axis signaling [21].
How to implement:
Protein intake:
Target: 1.0-1.2 grams per pound body weight
Sources: Grass-fed meat, wild fish, eggs, poultry, Greek yogurt, cottage cheese
Timing: 30-40 grams at breakfast (supports cortisol awakening response)
Healthy fats:
Target: 30-35% of daily calories from fat
Sources: Egg yolks, grass-fed butter, ghee, avocado, olive oil, coconut oil, fatty fish
Cholesterol important: Eggs, organ meats (cortisol precursor)
Avoid:
Very low-calorie diets (<1,500 calories/day)-suppress cortisol production by 30-50%
Very low-carb diets long-term-can blunt cortisol awakening response (need some carbs for HPA axis)
Evidence:
A study found that increasing dietary fat from 20% to 40% of calories raised morning cortisol by 18% in individuals with low baseline levels [22].

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6. Add Pantothenic Acid (Vitamin B5) and B-Complex
Why it works:
Pantothenic acid (vitamin B5) is critical for synthesis of coenzyme A, which is required for steroid hormone production in the adrenal glands. B vitamins also support cellular energy (ATP production), neurotransmitter synthesis, and stress resilience [23].
How to implement:
Pantothenic acid (B5):
Dosage: 500-1,000 mg daily (in divided doses)
Form: Calcium pantothenate or pantethine
Food sources: Organ meats (liver), mushrooms, avocado, eggs, legumes
B-Complex (comprehensive support):
Dosage: High-potency B-complex (B1, B2, B3, B5, B6, B12, folate)
B6: 25-50 mg (supports neurotransmitter production)
B12: 1,000 mcg (methylcobalamin for energy)
Folate: 400-800 mcg (methylfolate preferred)
Timing:
Take with breakfast (B vitamins can be energizing)
Evidence:
A trial in individuals with chronic fatigue found that pantothenic acid (1,000 mg daily) increased morning cortisol by 15% and improved fatigue scores by 30% over 8 weeks [24].
7. Strategic Exercise (Low-Intensity, Avoid Overtraining)
Why it works:
Exercise stimulates cortisol production-but the dose matters. Moderate exercise (30-60 min) raises cortisol acutely and improves HPA axis sensitivity long-term. However, high-intensity or prolonged exercise (>90 min) can further deplete cortisol in individuals with adrenal fatigue [25].
How to implement:
Best exercise types for low cortisol:
Walking: 30-60 minutes daily (gentle cortisol stimulation)
Yoga: Restorative or gentle flow (reduces stress, balances HPA axis)
Tai Chi or Qigong: Improves HPA axis regulation
Light strength training: 2-3x per week (20-30 min sessions)
Avoid:
HIIT or intense CrossFit-style training (further depletes cortisol)
Endurance exercise >90 minutes (marathon training, long cycling)
Fasted exercise (requires cortisol to mobilize energy-worsens fatigue)
Optimal timing:
Morning exercise (7-9 AM): Enhances cortisol awakening response
Outdoor exercise: Sunlight + movement = synergistic cortisol boost
Evidence:
A study found that 30 minutes of moderate walking (60-70% max HR) increased morning cortisol by 12% and improved HPA axis sensitivity in chronic fatigue patients, while high-intensity training worsened symptoms [26].
Get the Full Picture
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Testing Protocols - When and What to Measure
Baseline testing (before starting interventions):
4-point salivary cortisol (waking, noon, evening, bedtime)-gold standard for HPA axis function
DHEA-S (dehydroepiandrosterone sulfate)-adrenal reserve marker
ACTH stimulation test (if suspected Addison's-cortisol should rise after synthetic ACTH)
Serum cortisol (morning, 8 AM)-quick screen but less accurate than saliva
Vitamin C (serum or leukocyte)
Vitamin B5 (pantothenic acid, whole blood)
Electrolytes (sodium, potassium-check for hyponatremia)
Blood pressure (standing and lying-check for orthostatic hypotension)
Follow-up testing:
4-6 weeks: Repeat 4-point salivary cortisol (assess early response)
12 weeks: Full retest (assess optimization)
6 months: Maintenance testing
Optimal targets:
Morning cortisol: 13-24 nmol/L (salivary) or 10-20 mcg/dL (serum)
Cortisol awakening response: 50-100% increase from waking to 30 min post-wake
Total daily output: 40-60 nmol/L (sum of 4-point test)
DHEA-S: 200-400 mcg/dL (men), 100-300 mcg/dL (women)
Severe Adrenal Insufficiency (Addison's Disease)
Goal: Medical treatment with hydrocortisone + natural support
Medical:
Hydrocortisone: 15-25 mg daily (split doses: AM, noon, PM)-prescribed by endocrinologist
Fludrocortisone: 0.05-0.2 mg daily (aldosterone replacement)
Natural adjuncts:
Vitamin C: 1,000-2,000 mg daily
Sodium: 3,000-5,000 mg daily (liberal salt intake)
Adrenal cocktail: 2x daily
Adaptogen support: Rhodiola (200 mg AM), Ashwagandha (300 mg PM)
Critical: Do not attempt to replace medical treatment with natural methods. Addison's is life-threatening without hormone replacement.
Moderate Adrenal Insufficiency (Functional, Morning Cortisol 8-13 nmol/L)
Goal: Raise morning cortisol to >13 nmol/L, improve energy within 4-8 weeks
Sleep optimization: Consistent 10:30 PM bedtime, 7-9 hours, morning light exposure
Licorice root: 400 mg AM (monitor BP)
Rhodiola: 300-400 mg AM
Vitamin C: 2,000 mg daily (split doses)
Pantothenic acid: 500 mg 2x daily
Adrenal cocktail: Morning and mid-afternoon
Sodium: 2,500-3,500 mg daily
Protein: 1.0 g/lb body weight, 30-40g at breakfast
Healthy fats: 35% of calories
Exercise: 30 min walking daily (morning)
Retest: 6-8 weeks
Mild Adrenal Insufficiency (Morning Cortisol 10-13 nmol/L, Flattened Curve)
Goal: Optimize cortisol rhythm, improve resilience to stress
Sleep timing: Consistent schedule, morning light
Rhodiola: 200-300 mg AM
Ashwagandha: 300 mg AM (HPA axis balancing)
Vitamin C: 1,000 mg daily
B-Complex: High-potency daily
Adrenal cocktail: Morning
Protein: 30g at breakfast
Exercise: Moderate walking, yoga, avoid overtraining
Retest: 8-12 weeks
Recovery from Long-Term Steroid Use (Secondary Adrenal Insufficiency)
Goal: Gradually restore natural cortisol production as steroids taper
Work with doctor: Slow taper (reduce prednisone by 1-2.5 mg every 1-2 weeks)
Vitamin C: 2,000-3,000 mg daily
Pantothenic acid: 1,000 mg daily
Rhodiola: 300 mg AM
Licorice root: 300-500 mg AM (supports low cortisol during taper)
DHEA: 25-50 mg daily (if DHEA-S <100 mcg/dL)-consult doctor
Sleep: Critical-prioritize 8+ hours
Patience: Adrenal recovery can take 6-12 months post-taper
Monitoring: Test cortisol every 4-6 weeks during taper
Expected Timeline for Cortisol Recovery
Weeks 1-2:
Improved sleep quality (if using magnesium, ashwagandha)
Better stress tolerance
Reduced salt cravings
Weeks 4-6:
Increased morning energy (cortisol awakening response improving)
Better blood pressure stability
Reduced brain fog
Noticeable increase in resilience
Weeks 8-12:
Measurable increase in cortisol (4-point test shows improvement)
Sustained energy throughout day
Improved exercise tolerance
Less dizziness when standing
Months 3-6:
Full HPA axis recovery for most functional cases
Normal cortisol rhythm restored
Ability to handle stress without crashing
DHEA-S levels normalizing
When to Seek Medical Treatment
Natural approaches work best for:
Functional adrenal insufficiency ("adrenal fatigue")
HPA axis dysfunction from chronic stress
Recovery from short-term steroid use
Seek medical treatment immediately if:
Morning cortisol <5 mcg/dL (serum)
Symptoms of adrenal crisis: severe weakness, confusion, low blood pressure, nausea, vomiting
Weight loss, hyperpigmentation (darkening skin), severe salt cravings
Orthostatic hypotension (BP drops >20 mmHg when standing)
ACTH stimulation test confirms primary adrenal insufficiency
Addison's disease is a medical emergency-requires lifelong hydrocortisone replacement.
The Bottom Line
Raising cortisol naturally is possible for functional adrenal insufficiency and HPA axis dysfunction, but severe cases (Addison's disease) require medical treatment. The key is restoring circadian rhythm through sleep optimization and morning light, supporting adrenal function with vitamin C and B5, using adaptogens strategically (licorice, rhodiola, cordyceps), and ensuring adequate sodium, protein, and healthy fats.
Start with testing-4-point salivary cortisol is essential to understand your baseline and track progress. Most people with functional low cortisol see improvements in energy and stress tolerance within 4-6 weeks, with full HPA axis recovery in 3-6 months. Cortisol isn't the enemy-chronic imbalance is. Support your adrenal glands with the right nutrients, lifestyle, and adaptogens, and your body will restore its natural rhythm.
Key Takeaways
Optimal cortisol follows a rhythm: High in morning (8-20 mcg/dL), low at night (<2-3 mcg/dL)
MMA is functional deficiency: Serum cortisol <12 mcg/dL or blunted morning spike indicates dysfunction
Sleep is foundational: Proper circadian rhythm (early bed, sunlight morning) is non-negotiable
Adaptogens matter: Licorice, rhodiola, cordyceps support adrenal function without causing addiction
Nutritional support essential: Vitamin C (500-1,000 mg), B5 (500 mg), magnesium (400 mg), sodium (3-5g)
Test to track: 4-point salivary cortisol every 4-6 weeks; MMA should return to normal within 2-3 months
Timeline realistic: 4-6 weeks for energy improvement; 3-6 months for full HPA recovery
Medical Disclaimer
This article is for educational and informational purposes only and does not constitute medical advice. The information provided should not be used for diagnosing or treating a health condition. Always consult with your doctor or qualified healthcare provider before starting any new supplement protocol, making changes to your diet, or if you have questions about a medical condition.
Individual results may vary. The dosages and protocols discussed are evidence-based but should be personalized under medical supervision, especially if you have existing health conditions or take medications.
Track Your Progress
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References
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[3] Husebye ES, Pearce SH, Krone NP, Kämpe O. Adrenal insufficiency. Lancet. 2021;397(10274):613-629. PMID: 33484633 | DOI: 10.1016/S0140-6736(21)00136-7
[4] Silverman MN, Pearce BD, Biron CA, Miller AH. Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection. Viral Immunol. 2005;18(1):41-78.
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[12] Methlie P, Husebye EE, Hustad S, Lien EA, Løvås K. Grapefruit juice and licorice increase cortisol availability in patients with Addison's disease. Eur J Endocrinol. 2011;165(5):761-769.
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[17] Carr AC, Rosengrave PC, Bayer S, Chambers S, Mehrtens J, Shaw GM. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care. 2017;21(1):300. PMID: 29228951 | DOI: 10.1186/s13054-017-1891-y
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How to Raise Cortisol Naturally: 7 Evidence-Based Methods for Low Cortisol
Learn how to raise cortisol levels naturally for adrenal fatigue, chronic fatigue, and low morning cortisol. Evidence-based strategies using adaptogens, nutrition, sleep...

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Mito Health

How to Raise Cortisol Naturally - 7 Evidence-Based Methods for Low Cortisol
Quick Summary
Learn how to raise cortisol levels naturally for adrenal fatigue, chronic fatigue, and low morning cortisol. Evidence-based strategies using adaptogens, nutrition, sleep...
You wake up exhausted-no matter how much sleep you get. Your blood pressure is low, you crave salt constantly, and standing up makes you dizzy. Stressful situations that used to energize you now leave you feeling completely depleted.
Your doctor tests your cortisol and says it's "on the low side" but not low enough for Addison's disease.
What your doctor might not mention: cortisol isn't just a "stress hormone"-it's your body's primary energy regulator. It mobilizes glucose, maintains blood pressure, regulates inflammation, and coordinates your circadian rhythm. When cortisol is chronically low (adrenal insufficiency or "adrenal fatigue"), you experience debilitating fatigue, brain fog, low blood pressure, and an inability to handle stress.
What most people don't realize is that targeted cortisol optimization can help. While severe adrenal insufficiency (Addison's disease) requires medical treatment, functional low cortisol-often called "adrenal fatigue" or HPA axis dysfunction-can often be improved with nutrition, adaptogens, sleep optimization, and lifestyle interventions. Let's break down the 7 most effective methods-optimize from within.
What Is Low Cortisol?
Cortisol is produced by your adrenal glands in response to signals from the pituitary (ACTH) and hypothalamus (CRH). It follows a circadian rhythm:
Morning peak: Cortisol should be highest 30-60 minutes after waking (cortisol awakening response)
Gradual decline: Throughout the day
Lowest point: Midnight to 3 AM
Optimal cortisol levels (4-point salivary test):
Morning (7-9 AM): 13-24 nmol/L (awakening response)
Noon: 5-10 nmol/L
Evening (4-6 PM): 3-8 nmol/L
Bedtime: 1-4 nmol/L
Low cortisol is defined as:
Morning cortisol <13 nmol/L (waking sample)
Flattened cortisol curve (low morning, minimal decline throughout day)
Want to assess your cortisol rhythm? Our 4-point salivary cortisol test measures your levels throughout the day-capturing your unique pattern. Data-driven insights for HPA axis optimization.
Types of low cortisol:
Primary adrenal insufficiency (Addison's disease): Adrenal glands cannot produce cortisol-requires medical treatment with hydrocortisone
Secondary adrenal insufficiency: Pituitary doesn't produce enough ACTH-often due to long-term steroid use
Functional adrenal insufficiency ("adrenal fatigue"): HPA axis dysfunction, stress-induced cortisol depletion-responds to natural interventions
The reality is that "adrenal fatigue" is controversial in conventional medicine, but research shows HPA axis dysfunction is real. Studies find that chronic stress, inflammation, and poor sleep can suppress cortisol production and blunt the cortisol awakening response [1]. when you address the root causes.
Track Your Cortisol Levels
Mito Health tests 100+ biomarkers including 4-point salivary cortisol, DHEA-S, and stress markers with physician-guided protocols to help you optimize energy, stress resilience, and HPA axis function. Our comprehensive panels provide personalized interpretation to identify adrenal dysfunction early.
Why Does Low Cortisol Happen?
Root causes of low cortisol:
1. HPA Axis Dysregulation (Chronic Stress Burnout)
After prolonged periods of high stress (months to years), the hypothalamic-pituitary-adrenal (HPA) axis can become dysregulated. Initial stress elevates cortisol, but eventually, the system "burns out"-cortisol production drops, ACTH sensitivity decreases, and you enter a state of chronic low cortisol [2].
Common triggers:
Chronic work stress, caregiving, financial strain
Sleep deprivation (blunts morning cortisol by 20-50%)
Chronic illness or inflammation
Psychological trauma or PTSD
2. Autoimmune Destruction of Adrenal Glands (Addison's Disease)
In Addison's disease, the immune system attacks adrenal tissue, destroying cortisol-producing cells. This is a serious medical condition requiring lifelong hormone replacement. Symptoms include extreme fatigue, low blood pressure, hyperpigmentation (darkening skin), and salt cravings [3].
Testing:
ACTH stimulation test (cortisol doesn't rise after ACTH injection)
Adrenal antibodies (21-hydroxylase antibodies)
Serum cortisol <5 mcg/dL (morning) is diagnostic
3. Chronic Inflammation and Cytokine Effects
Inflammatory cytokines (IL-6, TNF-alpha) can suppress HPA axis function. Chronic inflammatory conditions like autoimmune diseases, gut dysbiosis, and obesity can blunt cortisol production and reduce cortisol receptor sensitivity [4].
4. Nutrient Deficiencies (Vitamin C, B5, Magnesium)
Cortisol synthesis requires specific nutrients:
Vitamin C: Adrenal glands have the highest concentration of vitamin C in the body-used in cortisol synthesis
Pantothenic acid (B5): Critical for steroid hormone production
Magnesium: Cofactor for HPA axis signaling
Cholesterol: Precursor to all steroid hormones (cortisol, testosterone, estrogen)
Deficiency in these nutrients can impair cortisol production [5].
5. Long-Term Steroid Use (Suppression of Natural Production)
Taking prednisone, dexamethasone, or other corticosteroids for >2 weeks suppresses natural cortisol production. When you stop, your adrenal glands may take months to recover-this is called secondary adrenal insufficiency. Tapering steroids slowly is critical [6].
6. Poor Sleep Quality and Circadian Disruption
Cortisol production is tightly linked to your circadian rhythm. Night shift work, jet lag, blue light exposure at night, and irregular sleep schedules disrupt the cortisol awakening response and flatten the daily cortisol curve [7].
1. Optimize Sleep Timing and Quality (Restore Circadian Rhythm)
Why it works:
Cortisol production is regulated by your circadian clock. The cortisol awakening response (CAR)-a 50-100% spike in cortisol 30-60 minutes after waking-is critical for energy and alertness. Poor sleep quality, late bedtimes, and shift work suppress morning cortisol by 20-50% [8].
How to implement:
Sleep timing:
Consistent sleep/wake times: Go to bed 10-11 PM, wake 6-7 AM (align with natural circadian rhythm)
7.5-9 hours total: Cortisol production recovers during deep sleep
Morning light exposure:
Within 30 minutes of waking: Get 10-30 minutes of bright light (ideally sunlight)
Why: Light exposure triggers cortisol release via the suprachiasmatic nucleus (SCN)
Research: Morning light increases cortisol awakening response by 30-50% [9]
Evening routine:
Dim lights after sunset: Bright light after 8 PM suppresses next-day cortisol
Avoid blue light: Blue-blocking glasses 2 hours before bed
Cool bedroom: 66-68°F (18-20°C) optimizes cortisol rhythm
Sleep quality optimization:
Magnesium glycinate: 300-400 mg before bed (improves deep sleep)
Glycine: 3 grams before bed (enhances sleep quality, supports cortisol rhythm)
Ashwagandha: 300-600 mg (balances cortisol-lowers if high, raises if low via HPA axis modulation)
Evidence:
A study found that individuals with consistent sleep schedules (same bedtime plus or minus 30 min) had 40% higher morning cortisol compared to irregular sleepers [10].
2. Use Adaptogenic Herbs (Support HPA Axis Recovery)
Why it works:
Adaptogens modulate the HPA axis, helping it respond appropriately to stress. In low-cortisol states, they support adrenal function and increase cortisol production. In high-cortisol states, they reduce excess cortisol-they're "bidirectional" [11].
How to implement:
Licorice Root (Glycyrrhiza glabra):
Mechanism: Inhibits 11β-HSD2 enzyme, which breaks down cortisol-extends cortisol half-life by 30-50%
Dosage: 300-500 mg extract (20% glycyrrhizin) daily
Timing: Morning (to enhance cortisol awakening response)
Caution: Can raise blood pressure (inhibits aldosterone breakdown)-monitor BP, avoid if hypertensive
Duration: 4-8 weeks maximum, then take 2-week break
Evidence: Licorice root increased serum cortisol by 25% in individuals with low baseline cortisol [12].
Rhodiola Rosea:
Mechanism: Supports HPA axis regulation, enhances stress resilience, increases cortisol output under stress
Dosage: 200-400 mg (3% rosavins, 1% salidroside) daily
Timing: Morning or early afternoon (can be stimulating)
Best for: Fatigue, mental fog, stress-related low cortisol
Evidence: Rhodiola increased cortisol awakening response by 18% in chronic fatigue patients [13].
Cordyceps (Cordyceps militaris):
Mechanism: Supports adrenal cortex function, increases cortisol production, enhances ATP production
Dosage: 1,000-3,000 mg daily (or 500-1,000 mg extract)
Timing: Morning (energizing)
Best for: Athletes, physical fatigue, low stamina
Evidence: Cordyceps increased morning cortisol by 12-15% and improved exercise performance in athletes [14].
Ashwagandha (Withania somnifera):
Mechanism: Bidirectional-lowers high cortisol, supports low cortisol by normalizing HPA axis
Dosage: 300-600 mg (Sensoril or KSM-66 extract) daily
Timing: Morning or bedtime (depending on whether you need energy or stress reduction)
Best for: Generalized HPA axis dysfunction
Evidence: Ashwagandha normalized cortisol patterns in stressed adults (raised low morning cortisol by 10-15%) [15].
Protocol for low cortisol:
Weeks 1-4: Rhodiola (300 mg AM) + Ashwagandha (300 mg AM)
Weeks 5-8: Add licorice root (400 mg AM) if cortisol still low
Maintenance: Rhodiola + Ashwagandha long-term, cycle licorice 4 weeks on / 2 weeks off
3. Supplement with Vitamin C (Critical for Cortisol Synthesis)
Why it works:
The adrenal glands have the highest concentration of vitamin C in the body. Vitamin C is a cofactor for enzymes that convert cholesterol to cortisol. During stress or illness, vitamin C is rapidly depleted from adrenal tissue, impairing cortisol production [16].
How to implement:
Dosing:
1,000-2,000 mg daily (split doses: 500 mg 2-4x daily)
Higher doses during stress: 3,000-5,000 mg daily (spread throughout day)
Form: Ascorbic acid or sodium ascorbate (avoid if sensitive to acidity)
Timing:
With meals (reduces GI irritation)
Morning dose important (supports cortisol awakening response)
Food sources (as adjunct):
Bell peppers, kiwi, citrus fruits, strawberries, broccoli
Evidence:
A study in critically ill patients found that vitamin C supplementation (3,000 mg daily) increased cortisol production by 30% and shortened recovery time [17]. Another trial showed that vitamin C (1,000 mg daily) improved cortisol response to stress in adults with low baseline levels [18].
Expected timeline:
Improvements in energy and stress tolerance within 2-4 weeks.
4. Increase Sodium Intake (Support Blood Pressure and Aldosterone)
Why it works:
Low cortisol is often accompanied by low aldosterone (both produced by adrenal glands). Aldosterone regulates sodium and potassium balance. Without sufficient aldosterone, you lose sodium, leading to low blood pressure, dizziness, and salt cravings. Increasing sodium intake helps stabilize blood pressure and supports adrenal function [19].
How to implement:
Salt intake:
Add 1-2 teaspoons unrefined sea salt daily (Celtic sea salt, Himalayan pink salt)
Liberally salt meals (especially if you crave salt)
Salt in water: 1/4 teaspoon in 16 oz water in morning (adrenal cocktail)
Adrenal cocktail (supports cortisol and electrolyte balance):
Recipe: 4 oz orange juice (vitamin C) + 1/4 tsp sea salt + 1/4 tsp cream of tartar (potassium)
Timing: Morning and mid-afternoon (when cortisol should peak)
Benefits: Vitamin C + sodium + potassium supports adrenal function
Caution:
Check blood pressure regularly
If BP remains low (<100/60), consult doctor (may need fludrocortisone)
Evidence:
Increased sodium intake (2,500-3,500 mg daily) improved blood pressure and reduced fatigue symptoms in adrenal insufficiency patients not yet on medication [20].
5. Consume Adequate Protein and Healthy Fats (Support Hormone Production)
Why it works:
Cortisol is synthesized from cholesterol. Low-fat diets and inadequate protein reduce the building blocks needed for steroid hormone production. Protein provides amino acids (tyrosine, phenylalanine) for neurotransmitters that regulate HPA axis signaling [21].
How to implement:
Protein intake:
Target: 1.0-1.2 grams per pound body weight
Sources: Grass-fed meat, wild fish, eggs, poultry, Greek yogurt, cottage cheese
Timing: 30-40 grams at breakfast (supports cortisol awakening response)
Healthy fats:
Target: 30-35% of daily calories from fat
Sources: Egg yolks, grass-fed butter, ghee, avocado, olive oil, coconut oil, fatty fish
Cholesterol important: Eggs, organ meats (cortisol precursor)
Avoid:
Very low-calorie diets (<1,500 calories/day)-suppress cortisol production by 30-50%
Very low-carb diets long-term-can blunt cortisol awakening response (need some carbs for HPA axis)
Evidence:
A study found that increasing dietary fat from 20% to 40% of calories raised morning cortisol by 18% in individuals with low baseline levels [22].

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6. Add Pantothenic Acid (Vitamin B5) and B-Complex
Why it works:
Pantothenic acid (vitamin B5) is critical for synthesis of coenzyme A, which is required for steroid hormone production in the adrenal glands. B vitamins also support cellular energy (ATP production), neurotransmitter synthesis, and stress resilience [23].
How to implement:
Pantothenic acid (B5):
Dosage: 500-1,000 mg daily (in divided doses)
Form: Calcium pantothenate or pantethine
Food sources: Organ meats (liver), mushrooms, avocado, eggs, legumes
B-Complex (comprehensive support):
Dosage: High-potency B-complex (B1, B2, B3, B5, B6, B12, folate)
B6: 25-50 mg (supports neurotransmitter production)
B12: 1,000 mcg (methylcobalamin for energy)
Folate: 400-800 mcg (methylfolate preferred)
Timing:
Take with breakfast (B vitamins can be energizing)
Evidence:
A trial in individuals with chronic fatigue found that pantothenic acid (1,000 mg daily) increased morning cortisol by 15% and improved fatigue scores by 30% over 8 weeks [24].
7. Strategic Exercise (Low-Intensity, Avoid Overtraining)
Why it works:
Exercise stimulates cortisol production-but the dose matters. Moderate exercise (30-60 min) raises cortisol acutely and improves HPA axis sensitivity long-term. However, high-intensity or prolonged exercise (>90 min) can further deplete cortisol in individuals with adrenal fatigue [25].
How to implement:
Best exercise types for low cortisol:
Walking: 30-60 minutes daily (gentle cortisol stimulation)
Yoga: Restorative or gentle flow (reduces stress, balances HPA axis)
Tai Chi or Qigong: Improves HPA axis regulation
Light strength training: 2-3x per week (20-30 min sessions)
Avoid:
HIIT or intense CrossFit-style training (further depletes cortisol)
Endurance exercise >90 minutes (marathon training, long cycling)
Fasted exercise (requires cortisol to mobilize energy-worsens fatigue)
Optimal timing:
Morning exercise (7-9 AM): Enhances cortisol awakening response
Outdoor exercise: Sunlight + movement = synergistic cortisol boost
Evidence:
A study found that 30 minutes of moderate walking (60-70% max HR) increased morning cortisol by 12% and improved HPA axis sensitivity in chronic fatigue patients, while high-intensity training worsened symptoms [26].
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Testing Protocols - When and What to Measure
Baseline testing (before starting interventions):
4-point salivary cortisol (waking, noon, evening, bedtime)-gold standard for HPA axis function
DHEA-S (dehydroepiandrosterone sulfate)-adrenal reserve marker
ACTH stimulation test (if suspected Addison's-cortisol should rise after synthetic ACTH)
Serum cortisol (morning, 8 AM)-quick screen but less accurate than saliva
Vitamin C (serum or leukocyte)
Vitamin B5 (pantothenic acid, whole blood)
Electrolytes (sodium, potassium-check for hyponatremia)
Blood pressure (standing and lying-check for orthostatic hypotension)
Follow-up testing:
4-6 weeks: Repeat 4-point salivary cortisol (assess early response)
12 weeks: Full retest (assess optimization)
6 months: Maintenance testing
Optimal targets:
Morning cortisol: 13-24 nmol/L (salivary) or 10-20 mcg/dL (serum)
Cortisol awakening response: 50-100% increase from waking to 30 min post-wake
Total daily output: 40-60 nmol/L (sum of 4-point test)
DHEA-S: 200-400 mcg/dL (men), 100-300 mcg/dL (women)
Severe Adrenal Insufficiency (Addison's Disease)
Goal: Medical treatment with hydrocortisone + natural support
Medical:
Hydrocortisone: 15-25 mg daily (split doses: AM, noon, PM)-prescribed by endocrinologist
Fludrocortisone: 0.05-0.2 mg daily (aldosterone replacement)
Natural adjuncts:
Vitamin C: 1,000-2,000 mg daily
Sodium: 3,000-5,000 mg daily (liberal salt intake)
Adrenal cocktail: 2x daily
Adaptogen support: Rhodiola (200 mg AM), Ashwagandha (300 mg PM)
Critical: Do not attempt to replace medical treatment with natural methods. Addison's is life-threatening without hormone replacement.
Moderate Adrenal Insufficiency (Functional, Morning Cortisol 8-13 nmol/L)
Goal: Raise morning cortisol to >13 nmol/L, improve energy within 4-8 weeks
Sleep optimization: Consistent 10:30 PM bedtime, 7-9 hours, morning light exposure
Licorice root: 400 mg AM (monitor BP)
Rhodiola: 300-400 mg AM
Vitamin C: 2,000 mg daily (split doses)
Pantothenic acid: 500 mg 2x daily
Adrenal cocktail: Morning and mid-afternoon
Sodium: 2,500-3,500 mg daily
Protein: 1.0 g/lb body weight, 30-40g at breakfast
Healthy fats: 35% of calories
Exercise: 30 min walking daily (morning)
Retest: 6-8 weeks
Mild Adrenal Insufficiency (Morning Cortisol 10-13 nmol/L, Flattened Curve)
Goal: Optimize cortisol rhythm, improve resilience to stress
Sleep timing: Consistent schedule, morning light
Rhodiola: 200-300 mg AM
Ashwagandha: 300 mg AM (HPA axis balancing)
Vitamin C: 1,000 mg daily
B-Complex: High-potency daily
Adrenal cocktail: Morning
Protein: 30g at breakfast
Exercise: Moderate walking, yoga, avoid overtraining
Retest: 8-12 weeks
Recovery from Long-Term Steroid Use (Secondary Adrenal Insufficiency)
Goal: Gradually restore natural cortisol production as steroids taper
Work with doctor: Slow taper (reduce prednisone by 1-2.5 mg every 1-2 weeks)
Vitamin C: 2,000-3,000 mg daily
Pantothenic acid: 1,000 mg daily
Rhodiola: 300 mg AM
Licorice root: 300-500 mg AM (supports low cortisol during taper)
DHEA: 25-50 mg daily (if DHEA-S <100 mcg/dL)-consult doctor
Sleep: Critical-prioritize 8+ hours
Patience: Adrenal recovery can take 6-12 months post-taper
Monitoring: Test cortisol every 4-6 weeks during taper
Expected Timeline for Cortisol Recovery
Weeks 1-2:
Improved sleep quality (if using magnesium, ashwagandha)
Better stress tolerance
Reduced salt cravings
Weeks 4-6:
Increased morning energy (cortisol awakening response improving)
Better blood pressure stability
Reduced brain fog
Noticeable increase in resilience
Weeks 8-12:
Measurable increase in cortisol (4-point test shows improvement)
Sustained energy throughout day
Improved exercise tolerance
Less dizziness when standing
Months 3-6:
Full HPA axis recovery for most functional cases
Normal cortisol rhythm restored
Ability to handle stress without crashing
DHEA-S levels normalizing
When to Seek Medical Treatment
Natural approaches work best for:
Functional adrenal insufficiency ("adrenal fatigue")
HPA axis dysfunction from chronic stress
Recovery from short-term steroid use
Seek medical treatment immediately if:
Morning cortisol <5 mcg/dL (serum)
Symptoms of adrenal crisis: severe weakness, confusion, low blood pressure, nausea, vomiting
Weight loss, hyperpigmentation (darkening skin), severe salt cravings
Orthostatic hypotension (BP drops >20 mmHg when standing)
ACTH stimulation test confirms primary adrenal insufficiency
Addison's disease is a medical emergency-requires lifelong hydrocortisone replacement.
The Bottom Line
Raising cortisol naturally is possible for functional adrenal insufficiency and HPA axis dysfunction, but severe cases (Addison's disease) require medical treatment. The key is restoring circadian rhythm through sleep optimization and morning light, supporting adrenal function with vitamin C and B5, using adaptogens strategically (licorice, rhodiola, cordyceps), and ensuring adequate sodium, protein, and healthy fats.
Start with testing-4-point salivary cortisol is essential to understand your baseline and track progress. Most people with functional low cortisol see improvements in energy and stress tolerance within 4-6 weeks, with full HPA axis recovery in 3-6 months. Cortisol isn't the enemy-chronic imbalance is. Support your adrenal glands with the right nutrients, lifestyle, and adaptogens, and your body will restore its natural rhythm.
Key Takeaways
Optimal cortisol follows a rhythm: High in morning (8-20 mcg/dL), low at night (<2-3 mcg/dL)
MMA is functional deficiency: Serum cortisol <12 mcg/dL or blunted morning spike indicates dysfunction
Sleep is foundational: Proper circadian rhythm (early bed, sunlight morning) is non-negotiable
Adaptogens matter: Licorice, rhodiola, cordyceps support adrenal function without causing addiction
Nutritional support essential: Vitamin C (500-1,000 mg), B5 (500 mg), magnesium (400 mg), sodium (3-5g)
Test to track: 4-point salivary cortisol every 4-6 weeks; MMA should return to normal within 2-3 months
Timeline realistic: 4-6 weeks for energy improvement; 3-6 months for full HPA recovery
Medical Disclaimer
This article is for educational and informational purposes only and does not constitute medical advice. The information provided should not be used for diagnosing or treating a health condition. Always consult with your doctor or qualified healthcare provider before starting any new supplement protocol, making changes to your diet, or if you have questions about a medical condition.
Individual results may vary. The dosages and protocols discussed are evidence-based but should be personalized under medical supervision, especially if you have existing health conditions or take medications.
Track Your Progress
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References
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[3] Husebye ES, Pearce SH, Krone NP, Kämpe O. Adrenal insufficiency. Lancet. 2021;397(10274):613-629. PMID: 33484633 | DOI: 10.1016/S0140-6736(21)00136-7
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[12] Methlie P, Husebye EE, Hustad S, Lien EA, Løvås K. Grapefruit juice and licorice increase cortisol availability in patients with Addison's disease. Eur J Endocrinol. 2011;165(5):761-769.
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