Mito Health: Helping you live healthier, longer.
In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.
Timing the Fats: When Omega-3s Are Most Effective
Timing is a frequent question around omega-3 supplements. This article looks at how omega-3s fit into daily routines and why consistency tends to matter more than perfect timing.

Written by
Mito Team

What are omega‑3s
Omega‑3s are essential polyunsaturated fats — mainly EPA and DHA in marine sources and ALA in plants — that support heart and brain health and reliably lower triglycerides. How and when you take them affects how well they’re absorbed, how likely you are to notice side effects (like fishy burps), and whether a given dose is safe and effective for your goal.
How to take omega-3s
Omega‑3s are fat‑soluble, so the single most important timing tip is simple: take them with food that contains some fat. A fatty meal (for example, eggs or avocado at breakfast, a sandwich with olive oil‑based dressing, or an oily fish dinner) increases absorption substantially compared with taking a capsule on an empty stomach. Taking supplements with a meal also reduces reflux and the “fishy burp” many people dislike.
There’s no one correct hour to take omega‑3. Choose a meal you reliably eat every day:
If you prefer one dose, take it with your largest or fattiest meal.
If you take higher doses (more than about 1,000 mg total EPA+DHA per day), consider splitting into two smaller doses with two meals to improve absorption and reduce gastrointestinal side effects.
If fishy aftertaste is a problem, try an enteric‑coated product or take capsules with a meal and finish the meal before lying down.
Recommended intakes vary by goal:
General maintenance/heart health: aim for around 600–1,000 mg combined EPA + DHA per day (many guidance statements point to roughly 1 g/day as a useful target). This often equates to about 300–500 mg of EPA and 300–500 mg of DHA each.
Brain support / pregnancy considerations: many people ensure adequate DHA daily; typical supplemental amounts are within the maintenance range, but pregnancy needs are often discussed with a clinician.
High triglycerides: much higher doses (typically 2–4 g/day of purified EPA + DHA) are used to lower triglycerides; these doses are prescription strength in many places and should be managed by a healthcare professional.
If you eat oily fish regularly
If you eat 3–4 servings of oily fish (salmon, mackerel, sardines, herring) per week, you may already achieve recommended omega‑3 intakes and supplementation will be less necessary. Focus on total dietary intake of EPA + DHA rather than automatically adding a supplement.
Choosing a supplement: what to look for
Check the EPA + DHA content on the label. Total “fish oil” weight can be much higher than the active omega‑3 amount; concentrate on the milligrams of EPA and DHA per serving. Concentrations can vary widely (some products supply 30% of their oil as EPA+DHA, while others exceed 80%).
For vegetarians/vegans, algal oil provides EPA and DHA in usable forms.
Enteric‑coated capsules can reduce fishy aftertaste.
Look for third‑party testing (USP, NSF, or equivalent) and a fresh smell. Brands commonly available that meet third‑party testing standards in many markets include Now Foods, Life Extension, GNC, PURE Encapsulations; vegetarian options include Carlson Vegetarian DHA, DEVA, and Ovega‑3. (Availability varies by country.)
Storage and freshness
Omega‑3 oils can oxidize and go rancid. Rancid oil tastes bad and is less effective. Store capsules in a cool, dark place; in warmer climates keep them refrigerated. Check the smell before use — a strong off or bitter odor suggests the oil may be oxidized; discard if doubtful.
Safety and interactions
Mild side effects: fishy aftertaste, burps, and mild gastrointestinal upset are common but often reduced by taking with food, splitting doses, or using enteric coatings.
Bleeding risk: at higher doses (several grams per day) omega‑3s can increase bleeding tendency. If you take blood thinners, have a bleeding disorder, or are having surgery, discuss omega‑3 dosing with your clinician.
Pregnancy and medical conditions: if you’re pregnant, breastfeeding, on other medications, or have a chronic condition, talk to your healthcare provider about the right dose and product for you.
Quick practical plan
If you want general cardiovascular and brain support: choose a supplement that provides about 600–1,000 mg combined EPA + DHA per day, take it with a meal that contains fat, and store it in a cool place.
If you rarely eat oily fish, a daily supplement helps fill the gap. If you eat oily fish 3–4 times weekly, supplementation may be less necessary.
If your goal is to lower very high triglycerides, work with a clinician — higher, prescription doses are used and appropriate monitoring is needed.
Conclusion
Take omega‑3s with a fat‑containing meal to maximize absorption and minimize side effects. Match the dose to your goal — modest daily amounts for general health, and much higher prescription doses only under medical supervision — and choose products by their EPA + DHA content and freshness rather than by total oil weight. If you’re unsure what dose or product is right for you, ask a healthcare professional.
Join Mito Health’s annual membership to test 100+ biomarkers with concierge-level support from your care team.
Mito Health: Helping you live healthier, longer.
In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.
Timing the Fats: When Omega-3s Are Most Effective
Timing is a frequent question around omega-3 supplements. This article looks at how omega-3s fit into daily routines and why consistency tends to matter more than perfect timing.

Written by
Mito Team

What are omega‑3s
Omega‑3s are essential polyunsaturated fats — mainly EPA and DHA in marine sources and ALA in plants — that support heart and brain health and reliably lower triglycerides. How and when you take them affects how well they’re absorbed, how likely you are to notice side effects (like fishy burps), and whether a given dose is safe and effective for your goal.
How to take omega-3s
Omega‑3s are fat‑soluble, so the single most important timing tip is simple: take them with food that contains some fat. A fatty meal (for example, eggs or avocado at breakfast, a sandwich with olive oil‑based dressing, or an oily fish dinner) increases absorption substantially compared with taking a capsule on an empty stomach. Taking supplements with a meal also reduces reflux and the “fishy burp” many people dislike.
There’s no one correct hour to take omega‑3. Choose a meal you reliably eat every day:
If you prefer one dose, take it with your largest or fattiest meal.
If you take higher doses (more than about 1,000 mg total EPA+DHA per day), consider splitting into two smaller doses with two meals to improve absorption and reduce gastrointestinal side effects.
If fishy aftertaste is a problem, try an enteric‑coated product or take capsules with a meal and finish the meal before lying down.
Recommended intakes vary by goal:
General maintenance/heart health: aim for around 600–1,000 mg combined EPA + DHA per day (many guidance statements point to roughly 1 g/day as a useful target). This often equates to about 300–500 mg of EPA and 300–500 mg of DHA each.
Brain support / pregnancy considerations: many people ensure adequate DHA daily; typical supplemental amounts are within the maintenance range, but pregnancy needs are often discussed with a clinician.
High triglycerides: much higher doses (typically 2–4 g/day of purified EPA + DHA) are used to lower triglycerides; these doses are prescription strength in many places and should be managed by a healthcare professional.
If you eat oily fish regularly
If you eat 3–4 servings of oily fish (salmon, mackerel, sardines, herring) per week, you may already achieve recommended omega‑3 intakes and supplementation will be less necessary. Focus on total dietary intake of EPA + DHA rather than automatically adding a supplement.
Choosing a supplement: what to look for
Check the EPA + DHA content on the label. Total “fish oil” weight can be much higher than the active omega‑3 amount; concentrate on the milligrams of EPA and DHA per serving. Concentrations can vary widely (some products supply 30% of their oil as EPA+DHA, while others exceed 80%).
For vegetarians/vegans, algal oil provides EPA and DHA in usable forms.
Enteric‑coated capsules can reduce fishy aftertaste.
Look for third‑party testing (USP, NSF, or equivalent) and a fresh smell. Brands commonly available that meet third‑party testing standards in many markets include Now Foods, Life Extension, GNC, PURE Encapsulations; vegetarian options include Carlson Vegetarian DHA, DEVA, and Ovega‑3. (Availability varies by country.)
Storage and freshness
Omega‑3 oils can oxidize and go rancid. Rancid oil tastes bad and is less effective. Store capsules in a cool, dark place; in warmer climates keep them refrigerated. Check the smell before use — a strong off or bitter odor suggests the oil may be oxidized; discard if doubtful.
Safety and interactions
Mild side effects: fishy aftertaste, burps, and mild gastrointestinal upset are common but often reduced by taking with food, splitting doses, or using enteric coatings.
Bleeding risk: at higher doses (several grams per day) omega‑3s can increase bleeding tendency. If you take blood thinners, have a bleeding disorder, or are having surgery, discuss omega‑3 dosing with your clinician.
Pregnancy and medical conditions: if you’re pregnant, breastfeeding, on other medications, or have a chronic condition, talk to your healthcare provider about the right dose and product for you.
Quick practical plan
If you want general cardiovascular and brain support: choose a supplement that provides about 600–1,000 mg combined EPA + DHA per day, take it with a meal that contains fat, and store it in a cool place.
If you rarely eat oily fish, a daily supplement helps fill the gap. If you eat oily fish 3–4 times weekly, supplementation may be less necessary.
If your goal is to lower very high triglycerides, work with a clinician — higher, prescription doses are used and appropriate monitoring is needed.
Conclusion
Take omega‑3s with a fat‑containing meal to maximize absorption and minimize side effects. Match the dose to your goal — modest daily amounts for general health, and much higher prescription doses only under medical supervision — and choose products by their EPA + DHA content and freshness rather than by total oil weight. If you’re unsure what dose or product is right for you, ask a healthcare professional.
Join Mito Health’s annual membership to test 100+ biomarkers with concierge-level support from your care team.
Mito Health: Helping you live healthier, longer.
In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.
Timing the Fats: When Omega-3s Are Most Effective
Timing is a frequent question around omega-3 supplements. This article looks at how omega-3s fit into daily routines and why consistency tends to matter more than perfect timing.

Written by
Mito Team

What are omega‑3s
Omega‑3s are essential polyunsaturated fats — mainly EPA and DHA in marine sources and ALA in plants — that support heart and brain health and reliably lower triglycerides. How and when you take them affects how well they’re absorbed, how likely you are to notice side effects (like fishy burps), and whether a given dose is safe and effective for your goal.
How to take omega-3s
Omega‑3s are fat‑soluble, so the single most important timing tip is simple: take them with food that contains some fat. A fatty meal (for example, eggs or avocado at breakfast, a sandwich with olive oil‑based dressing, or an oily fish dinner) increases absorption substantially compared with taking a capsule on an empty stomach. Taking supplements with a meal also reduces reflux and the “fishy burp” many people dislike.
There’s no one correct hour to take omega‑3. Choose a meal you reliably eat every day:
If you prefer one dose, take it with your largest or fattiest meal.
If you take higher doses (more than about 1,000 mg total EPA+DHA per day), consider splitting into two smaller doses with two meals to improve absorption and reduce gastrointestinal side effects.
If fishy aftertaste is a problem, try an enteric‑coated product or take capsules with a meal and finish the meal before lying down.
Recommended intakes vary by goal:
General maintenance/heart health: aim for around 600–1,000 mg combined EPA + DHA per day (many guidance statements point to roughly 1 g/day as a useful target). This often equates to about 300–500 mg of EPA and 300–500 mg of DHA each.
Brain support / pregnancy considerations: many people ensure adequate DHA daily; typical supplemental amounts are within the maintenance range, but pregnancy needs are often discussed with a clinician.
High triglycerides: much higher doses (typically 2–4 g/day of purified EPA + DHA) are used to lower triglycerides; these doses are prescription strength in many places and should be managed by a healthcare professional.
If you eat oily fish regularly
If you eat 3–4 servings of oily fish (salmon, mackerel, sardines, herring) per week, you may already achieve recommended omega‑3 intakes and supplementation will be less necessary. Focus on total dietary intake of EPA + DHA rather than automatically adding a supplement.
Choosing a supplement: what to look for
Check the EPA + DHA content on the label. Total “fish oil” weight can be much higher than the active omega‑3 amount; concentrate on the milligrams of EPA and DHA per serving. Concentrations can vary widely (some products supply 30% of their oil as EPA+DHA, while others exceed 80%).
For vegetarians/vegans, algal oil provides EPA and DHA in usable forms.
Enteric‑coated capsules can reduce fishy aftertaste.
Look for third‑party testing (USP, NSF, or equivalent) and a fresh smell. Brands commonly available that meet third‑party testing standards in many markets include Now Foods, Life Extension, GNC, PURE Encapsulations; vegetarian options include Carlson Vegetarian DHA, DEVA, and Ovega‑3. (Availability varies by country.)
Storage and freshness
Omega‑3 oils can oxidize and go rancid. Rancid oil tastes bad and is less effective. Store capsules in a cool, dark place; in warmer climates keep them refrigerated. Check the smell before use — a strong off or bitter odor suggests the oil may be oxidized; discard if doubtful.
Safety and interactions
Mild side effects: fishy aftertaste, burps, and mild gastrointestinal upset are common but often reduced by taking with food, splitting doses, or using enteric coatings.
Bleeding risk: at higher doses (several grams per day) omega‑3s can increase bleeding tendency. If you take blood thinners, have a bleeding disorder, or are having surgery, discuss omega‑3 dosing with your clinician.
Pregnancy and medical conditions: if you’re pregnant, breastfeeding, on other medications, or have a chronic condition, talk to your healthcare provider about the right dose and product for you.
Quick practical plan
If you want general cardiovascular and brain support: choose a supplement that provides about 600–1,000 mg combined EPA + DHA per day, take it with a meal that contains fat, and store it in a cool place.
If you rarely eat oily fish, a daily supplement helps fill the gap. If you eat oily fish 3–4 times weekly, supplementation may be less necessary.
If your goal is to lower very high triglycerides, work with a clinician — higher, prescription doses are used and appropriate monitoring is needed.
Conclusion
Take omega‑3s with a fat‑containing meal to maximize absorption and minimize side effects. Match the dose to your goal — modest daily amounts for general health, and much higher prescription doses only under medical supervision — and choose products by their EPA + DHA content and freshness rather than by total oil weight. If you’re unsure what dose or product is right for you, ask a healthcare professional.
Join Mito Health’s annual membership to test 100+ biomarkers with concierge-level support from your care team.
Timing the Fats: When Omega-3s Are Most Effective
Timing is a frequent question around omega-3 supplements. This article looks at how omega-3s fit into daily routines and why consistency tends to matter more than perfect timing.

Written by
Mito Team

What are omega‑3s
Omega‑3s are essential polyunsaturated fats — mainly EPA and DHA in marine sources and ALA in plants — that support heart and brain health and reliably lower triglycerides. How and when you take them affects how well they’re absorbed, how likely you are to notice side effects (like fishy burps), and whether a given dose is safe and effective for your goal.
How to take omega-3s
Omega‑3s are fat‑soluble, so the single most important timing tip is simple: take them with food that contains some fat. A fatty meal (for example, eggs or avocado at breakfast, a sandwich with olive oil‑based dressing, or an oily fish dinner) increases absorption substantially compared with taking a capsule on an empty stomach. Taking supplements with a meal also reduces reflux and the “fishy burp” many people dislike.
There’s no one correct hour to take omega‑3. Choose a meal you reliably eat every day:
If you prefer one dose, take it with your largest or fattiest meal.
If you take higher doses (more than about 1,000 mg total EPA+DHA per day), consider splitting into two smaller doses with two meals to improve absorption and reduce gastrointestinal side effects.
If fishy aftertaste is a problem, try an enteric‑coated product or take capsules with a meal and finish the meal before lying down.
Recommended intakes vary by goal:
General maintenance/heart health: aim for around 600–1,000 mg combined EPA + DHA per day (many guidance statements point to roughly 1 g/day as a useful target). This often equates to about 300–500 mg of EPA and 300–500 mg of DHA each.
Brain support / pregnancy considerations: many people ensure adequate DHA daily; typical supplemental amounts are within the maintenance range, but pregnancy needs are often discussed with a clinician.
High triglycerides: much higher doses (typically 2–4 g/day of purified EPA + DHA) are used to lower triglycerides; these doses are prescription strength in many places and should be managed by a healthcare professional.
If you eat oily fish regularly
If you eat 3–4 servings of oily fish (salmon, mackerel, sardines, herring) per week, you may already achieve recommended omega‑3 intakes and supplementation will be less necessary. Focus on total dietary intake of EPA + DHA rather than automatically adding a supplement.
Choosing a supplement: what to look for
Check the EPA + DHA content on the label. Total “fish oil” weight can be much higher than the active omega‑3 amount; concentrate on the milligrams of EPA and DHA per serving. Concentrations can vary widely (some products supply 30% of their oil as EPA+DHA, while others exceed 80%).
For vegetarians/vegans, algal oil provides EPA and DHA in usable forms.
Enteric‑coated capsules can reduce fishy aftertaste.
Look for third‑party testing (USP, NSF, or equivalent) and a fresh smell. Brands commonly available that meet third‑party testing standards in many markets include Now Foods, Life Extension, GNC, PURE Encapsulations; vegetarian options include Carlson Vegetarian DHA, DEVA, and Ovega‑3. (Availability varies by country.)
Storage and freshness
Omega‑3 oils can oxidize and go rancid. Rancid oil tastes bad and is less effective. Store capsules in a cool, dark place; in warmer climates keep them refrigerated. Check the smell before use — a strong off or bitter odor suggests the oil may be oxidized; discard if doubtful.
Safety and interactions
Mild side effects: fishy aftertaste, burps, and mild gastrointestinal upset are common but often reduced by taking with food, splitting doses, or using enteric coatings.
Bleeding risk: at higher doses (several grams per day) omega‑3s can increase bleeding tendency. If you take blood thinners, have a bleeding disorder, or are having surgery, discuss omega‑3 dosing with your clinician.
Pregnancy and medical conditions: if you’re pregnant, breastfeeding, on other medications, or have a chronic condition, talk to your healthcare provider about the right dose and product for you.
Quick practical plan
If you want general cardiovascular and brain support: choose a supplement that provides about 600–1,000 mg combined EPA + DHA per day, take it with a meal that contains fat, and store it in a cool place.
If you rarely eat oily fish, a daily supplement helps fill the gap. If you eat oily fish 3–4 times weekly, supplementation may be less necessary.
If your goal is to lower very high triglycerides, work with a clinician — higher, prescription doses are used and appropriate monitoring is needed.
Conclusion
Take omega‑3s with a fat‑containing meal to maximize absorption and minimize side effects. Match the dose to your goal — modest daily amounts for general health, and much higher prescription doses only under medical supervision — and choose products by their EPA + DHA content and freshness rather than by total oil weight. If you’re unsure what dose or product is right for you, ask a healthcare professional.
Join Mito Health’s annual membership to test 100+ biomarkers with concierge-level support from your care team.
Mito Health: Helping you live healthier, longer.
In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.
Recently published
What could cost you $15,000? $349 with Mito.
No hidden fees. No subscription traps. Just real care.
What's included
Core Test - Comprehensive lab test covering 100+ biomarkers
Clinician reviewed insights and action plan
1:1 consultation with a real clinician
Upload past lab reports for lifetime tracking
Dedicated 1:1 health coaching
Duo Bundle (For 2)
Most popular
$798
$668
$130 off (17%)
Individual
$399
$349
$50 off (13%)
What could cost you $15,000? $349 with Mito.
No hidden fees. No subscription traps. Just real care.
What's included
Core Test - Comprehensive lab test covering 100+ biomarkers
Clinician reviewed insights and action plan
1:1 consultation with a real clinician
Upload past lab reports for lifetime tracking
Dedicated 1:1 health coaching
Duo Bundle (For 2)
Most popular
$798
$668
$130 off (17%)
Individual
$399
$349
$50 off (13%)
What could cost you $15,000? $349 with Mito.
No hidden fees. No subscription traps. Just real care.
What's included
Core Test - Comprehensive lab test covering 100+ biomarkers
Clinician reviewed insights and action plan
1:1 consultation with a real clinician
Upload past lab reports for lifetime tracking
Dedicated 1:1 health coaching
Duo Bundle (For 2)
Most popular
$798
$668
$130 off (17%)
Individual
$399
$349
$50 off (13%)
What could cost you $15,000? $349 with Mito.
No hidden fees. No subscription traps. Just real care.
Core Test - Comprehensive lab test covering 100+ biomarkers
Clinician reviewed insights and action plan
1:1 consultation with a real clinician
Upload past lab reports for lifetime tracking
Dedicated 1:1 health coaching
What's included
Duo Bundle (For 2)
Most popular
$798
$668
$130 off (17%)
Individual
$399
$349
$50 off (13%)



