Mito Health: Helping you live healthier, longer.
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Why Vitamin K2 Belongs In Your Daily Stack
Vitamin K2 helps keep calcium in bones and out of arteries. Learn symptoms and risks of deficiency, how to eat or supplement K2 and when to be cautious.
Biomarkers
Written by
Gabriel Tan
If you want to live long with strong bones and clean arteries, vitamin K2 deserves a place near the top of your list. Most people hear “vitamin K” and think blood clotting. That is vitamin K1’s primary job.
Vitamin K2 drives a different set of proteins that move calcium to the right places. When K2 is adequate, calcium hardens bone and teeth. When K2 is low, calcium is more likely to drift into artery walls, heart valves and soft tissues where it does not belong.
Vitamin K’s family activates proteins through a reaction called carboxylation.
Two of the most important are osteocalcin in bone and matrix Gla protein in blood vessels. When these proteins are carboxylated, they bind calcium properly. When they are undercarboxylated, calcium control breaks down. That is where many downstream problems start.
Vitamin K1 vs Vitamin K2
Vitamin K1 is abundant in leafy greens and supports normal clotting. Vitamin K2 appears in fermented foods and select animal products.
K2 has several forms called menaquinones, often labeled MK-4 and MK-7. MK-7 has a longer half-life, so lower daily doses can maintain steady blood levels. MK-4 acts quickly but does not stay in the blood as long, so it is taken more often.
Both vitamin Ks can activate the proteins that guide calcium where it belongs.
Vitamin K2's Role in Heart and Bone Health
Low K2 status correlates with more vascular calcification and higher cardiovascular risk. Mechanistically this makes sense because matrix Gla protein is one of the body’s main anti-calcification brakes in vessels and it is vitamin K dependent.
On the skeletal side, K2 supports the carboxylation of osteocalcin, which helps lock calcium into the bone matrix. Diets that deliver adequate K2 are linked to better bone quality and fewer fractures over time.
There is also emerging research that K2 can support insulin sensitivity and lower certain inflammatory signals. The science here is still evolving, yet the direction is encouraging and consistent with the broader role of calcium handling and tissue health.
What Vitamin K2 Deficiency Looks Like
True, severe vitamin K deficiency presents with easy bruising and bleeding. That scenario is uncommon in healthy adults who eat regularly.
Suboptimal K2 intake is different, more common and quieter. You will not notice a day-to-day symptom, but over years it can show up as:
Faster progression of artery calcification that raises the risk of heart attack or stroke
Bone that is weaker than it should be for your age, with higher fracture risk
Calcification of soft tissues like heart valves that can impair function
Clinicians and researchers often measure undercarboxylated forms of K-dependent proteins to infer status. Two practical markers are undercarboxylated osteocalcin and desphospho-undercarboxylated matrix Gla protein.
If those are high, K-dependent activation is low.
Causes of Low Vitamin K2
Several patterns raise the odds of low K2 intake or impaired use. Diets that avoid fermented foods and most animal products often miss K2-rich sources.
Long courses of broad-spectrum antibiotics can disrupt gut bacteria that contribute menaquinones. Chronic illness with multiple medications can add friction as well.
Fat malabsorption syndromes and very low-fat diets reduce absorption of fat-soluble vitamins.
Food Sources That Move the Needle
Natto, a traditional fermented soybean food, is the most concentrated natural source of MK-7. Aged cheeses like Gouda or Jarlsberg deliver meaningful K2. Pasture-raised egg yolks and certain animal fats supply MK-4.
The win with foods is not just K2. You also get protein, minerals and bioactive compounds that support bone and vessel health. If natto’s flavor is not your thing, rotating aged cheeses, egg yolks and fermented foods can still build a solid base.
When Supplementation Makes Sense
Food first is a sound rule, but supplementation is reasonable when intake is low or when risk is high.
Many protocols use MK-7 in the range of 90 to 200 mcg per day with a meal that contains fat. MK-4 is sometimes used in higher divided doses. K2 pairs well with vitamin D and magnesium, since those nutrients also influence calcium balance. The point is synergy. You want calcium deposited into bone, not into arteries.
There is one crucial caution. If you take warfarin, a vitamin K antagonist, do not start K2 without medical guidance. Changes in vitamin K intake can alter warfarin’s effect, which is dangerous if unmanaged. Direct oral anticoagulants work differently, but you should still clear any supplement plan with your clinician.
Correcting Vitamin K2 Deficiencies
A lasting fix blends diet, lifestyle and targeted supplementation.
Start with food
Add natto once or twice a week if you tolerate it. Include aged cheeses, pasture-raised egg yolks and fermented foods.
If intake is still low, consider an MK-7 supplement in the 90 to 200 mcg range with a fat-containing meal. Consistency matters more than megadoses.
Build the foundation
Get enough vitamin D through sensible sun or supplementation and enough magnesium from foods like nuts, seeds and legumes.
Keep calcium in a moderate, food-forward range unless your clinician advises otherwise.
Do not smoke. Keep blood pressure, lipids and glucose under control. Weight train and walk. Sleep well. These habits determine where calcium ends up.
What Happens If You Do Nothing
The long arc of low K2 looks like the slow hardening of the body. Arteries calcify and stiffen, which raises blood pressure and strains the heart. Valves can calcify and leak or narrow.
Bones lose density and become fragile. The combination is what shortens healthspan. You will not notice it in a week but you will feel it in a decade.
Final Word
Vitamin K2 may not get the same attention as other vitamins, but its role in protecting your heart, bones, and overall longevity is undeniable. A deficiency can quietly drive serious health issues, yet the good news is that it is preventable and reversible with the right dietary choices and supplementation.
By making vitamin K2 a priority in your daily routine, you are not just correcting a deficiency, you are investing in a healthier future where your body is stronger, more resilient, and better protected against disease.
Resources
Related Articles
Mito Health: Helping you live healthier, longer.
In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.
Why Vitamin K2 Belongs In Your Daily Stack
Vitamin K2 helps keep calcium in bones and out of arteries. Learn symptoms and risks of deficiency, how to eat or supplement K2 and when to be cautious.
Biomarkers
Written by
Gabriel Tan
If you want to live long with strong bones and clean arteries, vitamin K2 deserves a place near the top of your list. Most people hear “vitamin K” and think blood clotting. That is vitamin K1’s primary job.
Vitamin K2 drives a different set of proteins that move calcium to the right places. When K2 is adequate, calcium hardens bone and teeth. When K2 is low, calcium is more likely to drift into artery walls, heart valves and soft tissues where it does not belong.
Vitamin K’s family activates proteins through a reaction called carboxylation.
Two of the most important are osteocalcin in bone and matrix Gla protein in blood vessels. When these proteins are carboxylated, they bind calcium properly. When they are undercarboxylated, calcium control breaks down. That is where many downstream problems start.
Vitamin K1 vs Vitamin K2
Vitamin K1 is abundant in leafy greens and supports normal clotting. Vitamin K2 appears in fermented foods and select animal products.
K2 has several forms called menaquinones, often labeled MK-4 and MK-7. MK-7 has a longer half-life, so lower daily doses can maintain steady blood levels. MK-4 acts quickly but does not stay in the blood as long, so it is taken more often.
Both vitamin Ks can activate the proteins that guide calcium where it belongs.
Vitamin K2's Role in Heart and Bone Health
Low K2 status correlates with more vascular calcification and higher cardiovascular risk. Mechanistically this makes sense because matrix Gla protein is one of the body’s main anti-calcification brakes in vessels and it is vitamin K dependent.
On the skeletal side, K2 supports the carboxylation of osteocalcin, which helps lock calcium into the bone matrix. Diets that deliver adequate K2 are linked to better bone quality and fewer fractures over time.
There is also emerging research that K2 can support insulin sensitivity and lower certain inflammatory signals. The science here is still evolving, yet the direction is encouraging and consistent with the broader role of calcium handling and tissue health.
What Vitamin K2 Deficiency Looks Like
True, severe vitamin K deficiency presents with easy bruising and bleeding. That scenario is uncommon in healthy adults who eat regularly.
Suboptimal K2 intake is different, more common and quieter. You will not notice a day-to-day symptom, but over years it can show up as:
Faster progression of artery calcification that raises the risk of heart attack or stroke
Bone that is weaker than it should be for your age, with higher fracture risk
Calcification of soft tissues like heart valves that can impair function
Clinicians and researchers often measure undercarboxylated forms of K-dependent proteins to infer status. Two practical markers are undercarboxylated osteocalcin and desphospho-undercarboxylated matrix Gla protein.
If those are high, K-dependent activation is low.
Causes of Low Vitamin K2
Several patterns raise the odds of low K2 intake or impaired use. Diets that avoid fermented foods and most animal products often miss K2-rich sources.
Long courses of broad-spectrum antibiotics can disrupt gut bacteria that contribute menaquinones. Chronic illness with multiple medications can add friction as well.
Fat malabsorption syndromes and very low-fat diets reduce absorption of fat-soluble vitamins.
Food Sources That Move the Needle
Natto, a traditional fermented soybean food, is the most concentrated natural source of MK-7. Aged cheeses like Gouda or Jarlsberg deliver meaningful K2. Pasture-raised egg yolks and certain animal fats supply MK-4.
The win with foods is not just K2. You also get protein, minerals and bioactive compounds that support bone and vessel health. If natto’s flavor is not your thing, rotating aged cheeses, egg yolks and fermented foods can still build a solid base.
When Supplementation Makes Sense
Food first is a sound rule, but supplementation is reasonable when intake is low or when risk is high.
Many protocols use MK-7 in the range of 90 to 200 mcg per day with a meal that contains fat. MK-4 is sometimes used in higher divided doses. K2 pairs well with vitamin D and magnesium, since those nutrients also influence calcium balance. The point is synergy. You want calcium deposited into bone, not into arteries.
There is one crucial caution. If you take warfarin, a vitamin K antagonist, do not start K2 without medical guidance. Changes in vitamin K intake can alter warfarin’s effect, which is dangerous if unmanaged. Direct oral anticoagulants work differently, but you should still clear any supplement plan with your clinician.
Correcting Vitamin K2 Deficiencies
A lasting fix blends diet, lifestyle and targeted supplementation.
Start with food
Add natto once or twice a week if you tolerate it. Include aged cheeses, pasture-raised egg yolks and fermented foods.
If intake is still low, consider an MK-7 supplement in the 90 to 200 mcg range with a fat-containing meal. Consistency matters more than megadoses.
Build the foundation
Get enough vitamin D through sensible sun or supplementation and enough magnesium from foods like nuts, seeds and legumes.
Keep calcium in a moderate, food-forward range unless your clinician advises otherwise.
Do not smoke. Keep blood pressure, lipids and glucose under control. Weight train and walk. Sleep well. These habits determine where calcium ends up.
What Happens If You Do Nothing
The long arc of low K2 looks like the slow hardening of the body. Arteries calcify and stiffen, which raises blood pressure and strains the heart. Valves can calcify and leak or narrow.
Bones lose density and become fragile. The combination is what shortens healthspan. You will not notice it in a week but you will feel it in a decade.
Final Word
Vitamin K2 may not get the same attention as other vitamins, but its role in protecting your heart, bones, and overall longevity is undeniable. A deficiency can quietly drive serious health issues, yet the good news is that it is preventable and reversible with the right dietary choices and supplementation.
By making vitamin K2 a priority in your daily routine, you are not just correcting a deficiency, you are investing in a healthier future where your body is stronger, more resilient, and better protected against disease.
Resources
Related Articles
Mito Health: Helping you live healthier, longer.
In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.
Why Vitamin K2 Belongs In Your Daily Stack
Vitamin K2 helps keep calcium in bones and out of arteries. Learn symptoms and risks of deficiency, how to eat or supplement K2 and when to be cautious.
Biomarkers
Written by
Gabriel Tan
If you want to live long with strong bones and clean arteries, vitamin K2 deserves a place near the top of your list. Most people hear “vitamin K” and think blood clotting. That is vitamin K1’s primary job.
Vitamin K2 drives a different set of proteins that move calcium to the right places. When K2 is adequate, calcium hardens bone and teeth. When K2 is low, calcium is more likely to drift into artery walls, heart valves and soft tissues where it does not belong.
Vitamin K’s family activates proteins through a reaction called carboxylation.
Two of the most important are osteocalcin in bone and matrix Gla protein in blood vessels. When these proteins are carboxylated, they bind calcium properly. When they are undercarboxylated, calcium control breaks down. That is where many downstream problems start.
Vitamin K1 vs Vitamin K2
Vitamin K1 is abundant in leafy greens and supports normal clotting. Vitamin K2 appears in fermented foods and select animal products.
K2 has several forms called menaquinones, often labeled MK-4 and MK-7. MK-7 has a longer half-life, so lower daily doses can maintain steady blood levels. MK-4 acts quickly but does not stay in the blood as long, so it is taken more often.
Both vitamin Ks can activate the proteins that guide calcium where it belongs.
Vitamin K2's Role in Heart and Bone Health
Low K2 status correlates with more vascular calcification and higher cardiovascular risk. Mechanistically this makes sense because matrix Gla protein is one of the body’s main anti-calcification brakes in vessels and it is vitamin K dependent.
On the skeletal side, K2 supports the carboxylation of osteocalcin, which helps lock calcium into the bone matrix. Diets that deliver adequate K2 are linked to better bone quality and fewer fractures over time.
There is also emerging research that K2 can support insulin sensitivity and lower certain inflammatory signals. The science here is still evolving, yet the direction is encouraging and consistent with the broader role of calcium handling and tissue health.
What Vitamin K2 Deficiency Looks Like
True, severe vitamin K deficiency presents with easy bruising and bleeding. That scenario is uncommon in healthy adults who eat regularly.
Suboptimal K2 intake is different, more common and quieter. You will not notice a day-to-day symptom, but over years it can show up as:
Faster progression of artery calcification that raises the risk of heart attack or stroke
Bone that is weaker than it should be for your age, with higher fracture risk
Calcification of soft tissues like heart valves that can impair function
Clinicians and researchers often measure undercarboxylated forms of K-dependent proteins to infer status. Two practical markers are undercarboxylated osteocalcin and desphospho-undercarboxylated matrix Gla protein.
If those are high, K-dependent activation is low.
Causes of Low Vitamin K2
Several patterns raise the odds of low K2 intake or impaired use. Diets that avoid fermented foods and most animal products often miss K2-rich sources.
Long courses of broad-spectrum antibiotics can disrupt gut bacteria that contribute menaquinones. Chronic illness with multiple medications can add friction as well.
Fat malabsorption syndromes and very low-fat diets reduce absorption of fat-soluble vitamins.
Food Sources That Move the Needle
Natto, a traditional fermented soybean food, is the most concentrated natural source of MK-7. Aged cheeses like Gouda or Jarlsberg deliver meaningful K2. Pasture-raised egg yolks and certain animal fats supply MK-4.
The win with foods is not just K2. You also get protein, minerals and bioactive compounds that support bone and vessel health. If natto’s flavor is not your thing, rotating aged cheeses, egg yolks and fermented foods can still build a solid base.
When Supplementation Makes Sense
Food first is a sound rule, but supplementation is reasonable when intake is low or when risk is high.
Many protocols use MK-7 in the range of 90 to 200 mcg per day with a meal that contains fat. MK-4 is sometimes used in higher divided doses. K2 pairs well with vitamin D and magnesium, since those nutrients also influence calcium balance. The point is synergy. You want calcium deposited into bone, not into arteries.
There is one crucial caution. If you take warfarin, a vitamin K antagonist, do not start K2 without medical guidance. Changes in vitamin K intake can alter warfarin’s effect, which is dangerous if unmanaged. Direct oral anticoagulants work differently, but you should still clear any supplement plan with your clinician.
Correcting Vitamin K2 Deficiencies
A lasting fix blends diet, lifestyle and targeted supplementation.
Start with food
Add natto once or twice a week if you tolerate it. Include aged cheeses, pasture-raised egg yolks and fermented foods.
If intake is still low, consider an MK-7 supplement in the 90 to 200 mcg range with a fat-containing meal. Consistency matters more than megadoses.
Build the foundation
Get enough vitamin D through sensible sun or supplementation and enough magnesium from foods like nuts, seeds and legumes.
Keep calcium in a moderate, food-forward range unless your clinician advises otherwise.
Do not smoke. Keep blood pressure, lipids and glucose under control. Weight train and walk. Sleep well. These habits determine where calcium ends up.
What Happens If You Do Nothing
The long arc of low K2 looks like the slow hardening of the body. Arteries calcify and stiffen, which raises blood pressure and strains the heart. Valves can calcify and leak or narrow.
Bones lose density and become fragile. The combination is what shortens healthspan. You will not notice it in a week but you will feel it in a decade.
Final Word
Vitamin K2 may not get the same attention as other vitamins, but its role in protecting your heart, bones, and overall longevity is undeniable. A deficiency can quietly drive serious health issues, yet the good news is that it is preventable and reversible with the right dietary choices and supplementation.
By making vitamin K2 a priority in your daily routine, you are not just correcting a deficiency, you are investing in a healthier future where your body is stronger, more resilient, and better protected against disease.
Resources
Related Articles
Why Vitamin K2 Belongs In Your Daily Stack
Vitamin K2 helps keep calcium in bones and out of arteries. Learn symptoms and risks of deficiency, how to eat or supplement K2 and when to be cautious.
Biomarkers
Written by
Gabriel Tan
If you want to live long with strong bones and clean arteries, vitamin K2 deserves a place near the top of your list. Most people hear “vitamin K” and think blood clotting. That is vitamin K1’s primary job.
Vitamin K2 drives a different set of proteins that move calcium to the right places. When K2 is adequate, calcium hardens bone and teeth. When K2 is low, calcium is more likely to drift into artery walls, heart valves and soft tissues where it does not belong.
Vitamin K’s family activates proteins through a reaction called carboxylation.
Two of the most important are osteocalcin in bone and matrix Gla protein in blood vessels. When these proteins are carboxylated, they bind calcium properly. When they are undercarboxylated, calcium control breaks down. That is where many downstream problems start.
Vitamin K1 vs Vitamin K2
Vitamin K1 is abundant in leafy greens and supports normal clotting. Vitamin K2 appears in fermented foods and select animal products.
K2 has several forms called menaquinones, often labeled MK-4 and MK-7. MK-7 has a longer half-life, so lower daily doses can maintain steady blood levels. MK-4 acts quickly but does not stay in the blood as long, so it is taken more often.
Both vitamin Ks can activate the proteins that guide calcium where it belongs.
Vitamin K2's Role in Heart and Bone Health
Low K2 status correlates with more vascular calcification and higher cardiovascular risk. Mechanistically this makes sense because matrix Gla protein is one of the body’s main anti-calcification brakes in vessels and it is vitamin K dependent.
On the skeletal side, K2 supports the carboxylation of osteocalcin, which helps lock calcium into the bone matrix. Diets that deliver adequate K2 are linked to better bone quality and fewer fractures over time.
There is also emerging research that K2 can support insulin sensitivity and lower certain inflammatory signals. The science here is still evolving, yet the direction is encouraging and consistent with the broader role of calcium handling and tissue health.
What Vitamin K2 Deficiency Looks Like
True, severe vitamin K deficiency presents with easy bruising and bleeding. That scenario is uncommon in healthy adults who eat regularly.
Suboptimal K2 intake is different, more common and quieter. You will not notice a day-to-day symptom, but over years it can show up as:
Faster progression of artery calcification that raises the risk of heart attack or stroke
Bone that is weaker than it should be for your age, with higher fracture risk
Calcification of soft tissues like heart valves that can impair function
Clinicians and researchers often measure undercarboxylated forms of K-dependent proteins to infer status. Two practical markers are undercarboxylated osteocalcin and desphospho-undercarboxylated matrix Gla protein.
If those are high, K-dependent activation is low.
Causes of Low Vitamin K2
Several patterns raise the odds of low K2 intake or impaired use. Diets that avoid fermented foods and most animal products often miss K2-rich sources.
Long courses of broad-spectrum antibiotics can disrupt gut bacteria that contribute menaquinones. Chronic illness with multiple medications can add friction as well.
Fat malabsorption syndromes and very low-fat diets reduce absorption of fat-soluble vitamins.
Food Sources That Move the Needle
Natto, a traditional fermented soybean food, is the most concentrated natural source of MK-7. Aged cheeses like Gouda or Jarlsberg deliver meaningful K2. Pasture-raised egg yolks and certain animal fats supply MK-4.
The win with foods is not just K2. You also get protein, minerals and bioactive compounds that support bone and vessel health. If natto’s flavor is not your thing, rotating aged cheeses, egg yolks and fermented foods can still build a solid base.
When Supplementation Makes Sense
Food first is a sound rule, but supplementation is reasonable when intake is low or when risk is high.
Many protocols use MK-7 in the range of 90 to 200 mcg per day with a meal that contains fat. MK-4 is sometimes used in higher divided doses. K2 pairs well with vitamin D and magnesium, since those nutrients also influence calcium balance. The point is synergy. You want calcium deposited into bone, not into arteries.
There is one crucial caution. If you take warfarin, a vitamin K antagonist, do not start K2 without medical guidance. Changes in vitamin K intake can alter warfarin’s effect, which is dangerous if unmanaged. Direct oral anticoagulants work differently, but you should still clear any supplement plan with your clinician.
Correcting Vitamin K2 Deficiencies
A lasting fix blends diet, lifestyle and targeted supplementation.
Start with food
Add natto once or twice a week if you tolerate it. Include aged cheeses, pasture-raised egg yolks and fermented foods.
If intake is still low, consider an MK-7 supplement in the 90 to 200 mcg range with a fat-containing meal. Consistency matters more than megadoses.
Build the foundation
Get enough vitamin D through sensible sun or supplementation and enough magnesium from foods like nuts, seeds and legumes.
Keep calcium in a moderate, food-forward range unless your clinician advises otherwise.
Do not smoke. Keep blood pressure, lipids and glucose under control. Weight train and walk. Sleep well. These habits determine where calcium ends up.
What Happens If You Do Nothing
The long arc of low K2 looks like the slow hardening of the body. Arteries calcify and stiffen, which raises blood pressure and strains the heart. Valves can calcify and leak or narrow.
Bones lose density and become fragile. The combination is what shortens healthspan. You will not notice it in a week but you will feel it in a decade.
Final Word
Vitamin K2 may not get the same attention as other vitamins, but its role in protecting your heart, bones, and overall longevity is undeniable. A deficiency can quietly drive serious health issues, yet the good news is that it is preventable and reversible with the right dietary choices and supplementation.
By making vitamin K2 a priority in your daily routine, you are not just correcting a deficiency, you are investing in a healthier future where your body is stronger, more resilient, and better protected against disease.
Resources
Related Articles
Mito Health: Helping you live healthier, longer.
In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.
Recently published
What could cost you $15,000? $349 with Mito.
No hidden fees. No subscription traps. Just real care.
What's included
Core Test - Comprehensive lab test covering 100+ biomarkers
Clinician reviewed insights and action plan
1:1 consultation with a real clinician
Upload past lab reports for lifetime tracking
Dedicated 1:1 health coaching
Duo Bundle (For 2)
Most popular
$798
$668
$130 off (17%)
Individual
$399
$349
$50 off (13%)
What could cost you $15,000? $349 with Mito.
No hidden fees. No subscription traps. Just real care.
What's included
Core Test - Comprehensive lab test covering 100+ biomarkers
Clinician reviewed insights and action plan
1:1 consultation with a real clinician
Upload past lab reports for lifetime tracking
Dedicated 1:1 health coaching
Duo Bundle (For 2)
Most popular
$798
$668
$130 off (17%)
Individual
$399
$349
$50 off (13%)
What could cost you $15,000? $349 with Mito.
No hidden fees. No subscription traps. Just real care.
What's included
Core Test - Comprehensive lab test covering 100+ biomarkers
Clinician reviewed insights and action plan
1:1 consultation with a real clinician
Upload past lab reports for lifetime tracking
Dedicated 1:1 health coaching
Duo Bundle (For 2)
Most popular
$798
$668
$130 off (17%)
Individual
$399
$349
$50 off (13%)
What could cost you $15,000? $349 with Mito.
No hidden fees. No subscription traps. Just real care.
Core Test - Comprehensive lab test covering 100+ biomarkers
Clinician reviewed insights and action plan
1:1 consultation with a real clinician
Upload past lab reports for lifetime tracking
Dedicated 1:1 health coaching
What's included
Duo Bundle (For 2)
Most popular
$798
$668
$130 off (17%)
Individual
$399
$349
$50 off (13%)