Mito Health: Helping you live healthier, longer.

In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.

Supplements You Should Take for Better Sleep

When sleep feels off, supplements often enter the conversation. This article explores why sleep issues are complex and how supplements fit into a bigger picture of sleep health.

Written by

Mito Team

Better sleep doesn’t always require prescription drugs. For many people, a few well-chosen supplements used sensibly—alongside good sleep habits—can help you fall asleep faster, sleep more soundly, or reduce nighttime restlessness. Below is a clear, practical guide to three commonly used supplements for sleep: melatonin, ashwagandha, and magnesium. For each one you’ll find what it does, how to use it, likely benefits, common side effects, and practical tips for choosing products.

How supplements can help sleep

  • Some supplements act on the sleep-wake system directly (for example, melatonin), while others support relaxation, reduce nighttime anxiety, or help muscles and nerves relax (ashwagandha, magnesium).

  • Supplements are best used as part of an overall sleep routine: consistent bed and wake times, limiting evening light exposure (especially screens), avoiding heavy meals, alcohol or stimulants late in the day, and creating a calm bedroom environment.

  • When trying any sleep supplement, start low, try one change at a time, and give a few nights to assess effects before adding another product.

Melatonin

  • Melatonin is a hormone your body makes to signal nighttime. Taken as a supplement, it helps shift or reinforce your sleep-wake timing and is particularly useful when falling asleep is the main problem.

How to use it
  • Timing: take 30–60 minutes before your desired bedtime.

  • Dose: start with a very low dose—0.5–1 mg. If that has no effect after a few nights, increase cautiously up to 3 mg. Avoid routinely taking very high doses (for example, 10 mg), which are more likely to cause morning grogginess and other unwanted effects.

  • Use pattern: use melatonin as needed (for travel, shift work, or short periods of insomnia) rather than every night long-term when possible.

What to expect
  • Melatonin typically helps you fall asleep faster but does not reliably increase total sleep duration. Lower doses tend to be effective and reduce the risk of next-day drowsiness.

Safety and practical tips
  • Many over-the-counter products contain 3–10 mg. Read labels carefully and choose a low-dose formulation if possible.

  • If you need a third-party tested product, options that are commonly available include NOW Liquid Melatonin and single-milligram products such as Swanson Melatonin 1 mg; if you need 3 mg, chewable options such as Trader Joe’s Chewable Melatonin 3 mg or Solgar Melatonin 3 mg are commonly suggested.

  • Avoid combining melatonin with other sedating medications without medical advice. Discuss melatonin use with a healthcare provider if you are pregnant, breastfeeding, taking prescription medications, or have a chronic medical condition.

Ashwagandha

  • Ashwagandha is a plant-based adaptogen used to support relaxation, reduce nighttime anxiety, and improve sleep quality for some people. It is also taken for recovery and physical performance, although benefits for those uses are more modest and less consistent.

How to use it
  • Typical extract doses: 500–1,500 mg taken in the evening.

  • If using root powder rather than a standardized extract, higher amounts are often used (1,000 mg or more). Start at the lower end and adjust based on how you feel.

What to expect
  • Many people report improved sleep quality and reduced anxiety after a period of nightly use; effects tend to develop over several days to a few weeks.

Safety and practical tips
  • Side effects are uncommon but can include sleepiness, headache, stomach upset (nausea or diarrhea), and allergic reactions. In rare cases, liver injury has been reported; stop the supplement and seek care if you develop stomach pain, persistent nausea, unusual fatigue, or yellowing of the skin or eyes.

  • If you have known liver disease, are pregnant or breastfeeding, or take prescription medications, check with a healthcare professional before starting ashwagandha.

  • Third‑party tested options include Nature’s Way Standardized Ashwagandha Extract, GNC Herbal Plus Ashwagandha Extract, Organic India Ashwagandha Powder, and Solgar Ashwagandha Root Extract.

Magnesium

  • Magnesium is an essential mineral involved in hundreds of bodily processes. Adequate magnesium supports muscle and nerve function and can help nighttime relaxation and reduce cramps, restless legs, and some types of headache that interfere with sleep.

How to use it
  • Aim to meet the recommended dietary allowance through food plus supplement as needed (RDA roughly 420 mg for adult men and 320 mg for adult women). Many people take magnesium in the evening to support relaxation; typical supplemental amounts vary, often in the 100–400 mg range of elemental magnesium depending on the formulation.

  • Forms matter: some forms are gentler on the gut and better absorbed without laxative effects; others are more likely to cause diarrhea at higher doses.

Choosing a form
  • Magnesium bisglycinate, magnesium chloride, and magnesium glycerophosphate or taurinate are good options for improving body magnesium with minimal laxative effect.

  • Magnesium citrate, gluconate, or lactate are well absorbed but are more likely to cause loose stools at higher doses.

  • Magnesium oxide is inexpensive but more likely to upset the stomach and cause diarrhea.

  • Magnesium L‑threonate is more expensive, usually provides lower elemental magnesium, and is chosen by some for potential brain-related benefits, though it is less optimal if your primary goal is to raise overall magnesium stores.

Safety and practical tips
  • If your stool becomes loose, reduce the dose or change the form.

  • If you are on medications, especially certain blood pressure drugs or medications that affect kidney function, check with a healthcare professional before starting magnesium supplementation.

  • Third-party tested options include NOW Magnesium Glycinate, InnovixLabs Advanced Magnesium, Nutricology Magnesium Chloride Liquid, and SlowMag.

How to choose and combine supplements

  • Start with basics first: consistent sleep habits and lifestyle changes are the foundation. Add one supplement at a time so you can judge its effect.

  • If difficulty is primarily falling asleep or shifting sleep timing (travel/jet lag), try low-dose melatonin first.

  • If stress or nighttime anxiety keeps you awake, consider ashwagandha in the evening.

  • If muscle cramps, restless legs, or general relaxation is the issue—or your diet is low in magnesium—consider magnesium in the evening.

  • Be cautious combining several sedating supplements at once; together they can increase morning sleepiness. Give each product a trial of a few nights to a few weeks before changing dose or adding another.

When to seek medical advice

  • Stop a supplement and seek care if you develop severe gastrointestinal symptoms, jaundice (yellowing of skin/eyes), severe allergic reaction, or unusual persistent fatigue.

  • Check with a healthcare professional if you are pregnant, breastfeeding, have significant medical conditions (especially liver or kidney disease), or take prescription medications that could interact with supplements.

A practical plan to try

  • Week 1–2: focus on sleep behavior (consistent schedule, reduce screen time before bed, comfortable environment).

  • Week 3: if you still struggle, add one low-dose supplement based on your main problem (melatonin 0.5–1 mg 30–60 minutes before bed for sleep-onset; magnesium in the evening for relaxation or cramps; ashwagandha 500 mg in the evening for anxiety-driven sleep problems).

  • Monitor effects and side effects for 1–3 weeks. Adjust dose gradually if needed, and avoid long-term nightly melatonin unless advised by a clinician.

Conclusion

Melatonin, ashwagandha, and magnesium can each help different aspects of sleep when used thoughtfully. Start low, prioritize sleep habits, monitor how you feel, and choose products that are third-party tested when possible. If you have underlying health conditions or take prescription drugs, get tailored advice from a healthcare professional before starting a new supplement.

Join Mito Health’s annual membership to test 100+ biomarkers with concierge-level support from your care team.

Mito Health: Helping you live healthier, longer.

In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.

Supplements You Should Take for Better Sleep

When sleep feels off, supplements often enter the conversation. This article explores why sleep issues are complex and how supplements fit into a bigger picture of sleep health.

Written by

Mito Team

Better sleep doesn’t always require prescription drugs. For many people, a few well-chosen supplements used sensibly—alongside good sleep habits—can help you fall asleep faster, sleep more soundly, or reduce nighttime restlessness. Below is a clear, practical guide to three commonly used supplements for sleep: melatonin, ashwagandha, and magnesium. For each one you’ll find what it does, how to use it, likely benefits, common side effects, and practical tips for choosing products.

How supplements can help sleep

  • Some supplements act on the sleep-wake system directly (for example, melatonin), while others support relaxation, reduce nighttime anxiety, or help muscles and nerves relax (ashwagandha, magnesium).

  • Supplements are best used as part of an overall sleep routine: consistent bed and wake times, limiting evening light exposure (especially screens), avoiding heavy meals, alcohol or stimulants late in the day, and creating a calm bedroom environment.

  • When trying any sleep supplement, start low, try one change at a time, and give a few nights to assess effects before adding another product.

Melatonin

  • Melatonin is a hormone your body makes to signal nighttime. Taken as a supplement, it helps shift or reinforce your sleep-wake timing and is particularly useful when falling asleep is the main problem.

How to use it
  • Timing: take 30–60 minutes before your desired bedtime.

  • Dose: start with a very low dose—0.5–1 mg. If that has no effect after a few nights, increase cautiously up to 3 mg. Avoid routinely taking very high doses (for example, 10 mg), which are more likely to cause morning grogginess and other unwanted effects.

  • Use pattern: use melatonin as needed (for travel, shift work, or short periods of insomnia) rather than every night long-term when possible.

What to expect
  • Melatonin typically helps you fall asleep faster but does not reliably increase total sleep duration. Lower doses tend to be effective and reduce the risk of next-day drowsiness.

Safety and practical tips
  • Many over-the-counter products contain 3–10 mg. Read labels carefully and choose a low-dose formulation if possible.

  • If you need a third-party tested product, options that are commonly available include NOW Liquid Melatonin and single-milligram products such as Swanson Melatonin 1 mg; if you need 3 mg, chewable options such as Trader Joe’s Chewable Melatonin 3 mg or Solgar Melatonin 3 mg are commonly suggested.

  • Avoid combining melatonin with other sedating medications without medical advice. Discuss melatonin use with a healthcare provider if you are pregnant, breastfeeding, taking prescription medications, or have a chronic medical condition.

Ashwagandha

  • Ashwagandha is a plant-based adaptogen used to support relaxation, reduce nighttime anxiety, and improve sleep quality for some people. It is also taken for recovery and physical performance, although benefits for those uses are more modest and less consistent.

How to use it
  • Typical extract doses: 500–1,500 mg taken in the evening.

  • If using root powder rather than a standardized extract, higher amounts are often used (1,000 mg or more). Start at the lower end and adjust based on how you feel.

What to expect
  • Many people report improved sleep quality and reduced anxiety after a period of nightly use; effects tend to develop over several days to a few weeks.

Safety and practical tips
  • Side effects are uncommon but can include sleepiness, headache, stomach upset (nausea or diarrhea), and allergic reactions. In rare cases, liver injury has been reported; stop the supplement and seek care if you develop stomach pain, persistent nausea, unusual fatigue, or yellowing of the skin or eyes.

  • If you have known liver disease, are pregnant or breastfeeding, or take prescription medications, check with a healthcare professional before starting ashwagandha.

  • Third‑party tested options include Nature’s Way Standardized Ashwagandha Extract, GNC Herbal Plus Ashwagandha Extract, Organic India Ashwagandha Powder, and Solgar Ashwagandha Root Extract.

Magnesium

  • Magnesium is an essential mineral involved in hundreds of bodily processes. Adequate magnesium supports muscle and nerve function and can help nighttime relaxation and reduce cramps, restless legs, and some types of headache that interfere with sleep.

How to use it
  • Aim to meet the recommended dietary allowance through food plus supplement as needed (RDA roughly 420 mg for adult men and 320 mg for adult women). Many people take magnesium in the evening to support relaxation; typical supplemental amounts vary, often in the 100–400 mg range of elemental magnesium depending on the formulation.

  • Forms matter: some forms are gentler on the gut and better absorbed without laxative effects; others are more likely to cause diarrhea at higher doses.

Choosing a form
  • Magnesium bisglycinate, magnesium chloride, and magnesium glycerophosphate or taurinate are good options for improving body magnesium with minimal laxative effect.

  • Magnesium citrate, gluconate, or lactate are well absorbed but are more likely to cause loose stools at higher doses.

  • Magnesium oxide is inexpensive but more likely to upset the stomach and cause diarrhea.

  • Magnesium L‑threonate is more expensive, usually provides lower elemental magnesium, and is chosen by some for potential brain-related benefits, though it is less optimal if your primary goal is to raise overall magnesium stores.

Safety and practical tips
  • If your stool becomes loose, reduce the dose or change the form.

  • If you are on medications, especially certain blood pressure drugs or medications that affect kidney function, check with a healthcare professional before starting magnesium supplementation.

  • Third-party tested options include NOW Magnesium Glycinate, InnovixLabs Advanced Magnesium, Nutricology Magnesium Chloride Liquid, and SlowMag.

How to choose and combine supplements

  • Start with basics first: consistent sleep habits and lifestyle changes are the foundation. Add one supplement at a time so you can judge its effect.

  • If difficulty is primarily falling asleep or shifting sleep timing (travel/jet lag), try low-dose melatonin first.

  • If stress or nighttime anxiety keeps you awake, consider ashwagandha in the evening.

  • If muscle cramps, restless legs, or general relaxation is the issue—or your diet is low in magnesium—consider magnesium in the evening.

  • Be cautious combining several sedating supplements at once; together they can increase morning sleepiness. Give each product a trial of a few nights to a few weeks before changing dose or adding another.

When to seek medical advice

  • Stop a supplement and seek care if you develop severe gastrointestinal symptoms, jaundice (yellowing of skin/eyes), severe allergic reaction, or unusual persistent fatigue.

  • Check with a healthcare professional if you are pregnant, breastfeeding, have significant medical conditions (especially liver or kidney disease), or take prescription medications that could interact with supplements.

A practical plan to try

  • Week 1–2: focus on sleep behavior (consistent schedule, reduce screen time before bed, comfortable environment).

  • Week 3: if you still struggle, add one low-dose supplement based on your main problem (melatonin 0.5–1 mg 30–60 minutes before bed for sleep-onset; magnesium in the evening for relaxation or cramps; ashwagandha 500 mg in the evening for anxiety-driven sleep problems).

  • Monitor effects and side effects for 1–3 weeks. Adjust dose gradually if needed, and avoid long-term nightly melatonin unless advised by a clinician.

Conclusion

Melatonin, ashwagandha, and magnesium can each help different aspects of sleep when used thoughtfully. Start low, prioritize sleep habits, monitor how you feel, and choose products that are third-party tested when possible. If you have underlying health conditions or take prescription drugs, get tailored advice from a healthcare professional before starting a new supplement.

Join Mito Health’s annual membership to test 100+ biomarkers with concierge-level support from your care team.

Mito Health: Helping you live healthier, longer.

In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.

Supplements You Should Take for Better Sleep

When sleep feels off, supplements often enter the conversation. This article explores why sleep issues are complex and how supplements fit into a bigger picture of sleep health.

Written by

Mito Team

Better sleep doesn’t always require prescription drugs. For many people, a few well-chosen supplements used sensibly—alongside good sleep habits—can help you fall asleep faster, sleep more soundly, or reduce nighttime restlessness. Below is a clear, practical guide to three commonly used supplements for sleep: melatonin, ashwagandha, and magnesium. For each one you’ll find what it does, how to use it, likely benefits, common side effects, and practical tips for choosing products.

How supplements can help sleep

  • Some supplements act on the sleep-wake system directly (for example, melatonin), while others support relaxation, reduce nighttime anxiety, or help muscles and nerves relax (ashwagandha, magnesium).

  • Supplements are best used as part of an overall sleep routine: consistent bed and wake times, limiting evening light exposure (especially screens), avoiding heavy meals, alcohol or stimulants late in the day, and creating a calm bedroom environment.

  • When trying any sleep supplement, start low, try one change at a time, and give a few nights to assess effects before adding another product.

Melatonin

  • Melatonin is a hormone your body makes to signal nighttime. Taken as a supplement, it helps shift or reinforce your sleep-wake timing and is particularly useful when falling asleep is the main problem.

How to use it
  • Timing: take 30–60 minutes before your desired bedtime.

  • Dose: start with a very low dose—0.5–1 mg. If that has no effect after a few nights, increase cautiously up to 3 mg. Avoid routinely taking very high doses (for example, 10 mg), which are more likely to cause morning grogginess and other unwanted effects.

  • Use pattern: use melatonin as needed (for travel, shift work, or short periods of insomnia) rather than every night long-term when possible.

What to expect
  • Melatonin typically helps you fall asleep faster but does not reliably increase total sleep duration. Lower doses tend to be effective and reduce the risk of next-day drowsiness.

Safety and practical tips
  • Many over-the-counter products contain 3–10 mg. Read labels carefully and choose a low-dose formulation if possible.

  • If you need a third-party tested product, options that are commonly available include NOW Liquid Melatonin and single-milligram products such as Swanson Melatonin 1 mg; if you need 3 mg, chewable options such as Trader Joe’s Chewable Melatonin 3 mg or Solgar Melatonin 3 mg are commonly suggested.

  • Avoid combining melatonin with other sedating medications without medical advice. Discuss melatonin use with a healthcare provider if you are pregnant, breastfeeding, taking prescription medications, or have a chronic medical condition.

Ashwagandha

  • Ashwagandha is a plant-based adaptogen used to support relaxation, reduce nighttime anxiety, and improve sleep quality for some people. It is also taken for recovery and physical performance, although benefits for those uses are more modest and less consistent.

How to use it
  • Typical extract doses: 500–1,500 mg taken in the evening.

  • If using root powder rather than a standardized extract, higher amounts are often used (1,000 mg or more). Start at the lower end and adjust based on how you feel.

What to expect
  • Many people report improved sleep quality and reduced anxiety after a period of nightly use; effects tend to develop over several days to a few weeks.

Safety and practical tips
  • Side effects are uncommon but can include sleepiness, headache, stomach upset (nausea or diarrhea), and allergic reactions. In rare cases, liver injury has been reported; stop the supplement and seek care if you develop stomach pain, persistent nausea, unusual fatigue, or yellowing of the skin or eyes.

  • If you have known liver disease, are pregnant or breastfeeding, or take prescription medications, check with a healthcare professional before starting ashwagandha.

  • Third‑party tested options include Nature’s Way Standardized Ashwagandha Extract, GNC Herbal Plus Ashwagandha Extract, Organic India Ashwagandha Powder, and Solgar Ashwagandha Root Extract.

Magnesium

  • Magnesium is an essential mineral involved in hundreds of bodily processes. Adequate magnesium supports muscle and nerve function and can help nighttime relaxation and reduce cramps, restless legs, and some types of headache that interfere with sleep.

How to use it
  • Aim to meet the recommended dietary allowance through food plus supplement as needed (RDA roughly 420 mg for adult men and 320 mg for adult women). Many people take magnesium in the evening to support relaxation; typical supplemental amounts vary, often in the 100–400 mg range of elemental magnesium depending on the formulation.

  • Forms matter: some forms are gentler on the gut and better absorbed without laxative effects; others are more likely to cause diarrhea at higher doses.

Choosing a form
  • Magnesium bisglycinate, magnesium chloride, and magnesium glycerophosphate or taurinate are good options for improving body magnesium with minimal laxative effect.

  • Magnesium citrate, gluconate, or lactate are well absorbed but are more likely to cause loose stools at higher doses.

  • Magnesium oxide is inexpensive but more likely to upset the stomach and cause diarrhea.

  • Magnesium L‑threonate is more expensive, usually provides lower elemental magnesium, and is chosen by some for potential brain-related benefits, though it is less optimal if your primary goal is to raise overall magnesium stores.

Safety and practical tips
  • If your stool becomes loose, reduce the dose or change the form.

  • If you are on medications, especially certain blood pressure drugs or medications that affect kidney function, check with a healthcare professional before starting magnesium supplementation.

  • Third-party tested options include NOW Magnesium Glycinate, InnovixLabs Advanced Magnesium, Nutricology Magnesium Chloride Liquid, and SlowMag.

How to choose and combine supplements

  • Start with basics first: consistent sleep habits and lifestyle changes are the foundation. Add one supplement at a time so you can judge its effect.

  • If difficulty is primarily falling asleep or shifting sleep timing (travel/jet lag), try low-dose melatonin first.

  • If stress or nighttime anxiety keeps you awake, consider ashwagandha in the evening.

  • If muscle cramps, restless legs, or general relaxation is the issue—or your diet is low in magnesium—consider magnesium in the evening.

  • Be cautious combining several sedating supplements at once; together they can increase morning sleepiness. Give each product a trial of a few nights to a few weeks before changing dose or adding another.

When to seek medical advice

  • Stop a supplement and seek care if you develop severe gastrointestinal symptoms, jaundice (yellowing of skin/eyes), severe allergic reaction, or unusual persistent fatigue.

  • Check with a healthcare professional if you are pregnant, breastfeeding, have significant medical conditions (especially liver or kidney disease), or take prescription medications that could interact with supplements.

A practical plan to try

  • Week 1–2: focus on sleep behavior (consistent schedule, reduce screen time before bed, comfortable environment).

  • Week 3: if you still struggle, add one low-dose supplement based on your main problem (melatonin 0.5–1 mg 30–60 minutes before bed for sleep-onset; magnesium in the evening for relaxation or cramps; ashwagandha 500 mg in the evening for anxiety-driven sleep problems).

  • Monitor effects and side effects for 1–3 weeks. Adjust dose gradually if needed, and avoid long-term nightly melatonin unless advised by a clinician.

Conclusion

Melatonin, ashwagandha, and magnesium can each help different aspects of sleep when used thoughtfully. Start low, prioritize sleep habits, monitor how you feel, and choose products that are third-party tested when possible. If you have underlying health conditions or take prescription drugs, get tailored advice from a healthcare professional before starting a new supplement.

Join Mito Health’s annual membership to test 100+ biomarkers with concierge-level support from your care team.

Supplements You Should Take for Better Sleep

When sleep feels off, supplements often enter the conversation. This article explores why sleep issues are complex and how supplements fit into a bigger picture of sleep health.

Written by

Mito Team

Better sleep doesn’t always require prescription drugs. For many people, a few well-chosen supplements used sensibly—alongside good sleep habits—can help you fall asleep faster, sleep more soundly, or reduce nighttime restlessness. Below is a clear, practical guide to three commonly used supplements for sleep: melatonin, ashwagandha, and magnesium. For each one you’ll find what it does, how to use it, likely benefits, common side effects, and practical tips for choosing products.

How supplements can help sleep

  • Some supplements act on the sleep-wake system directly (for example, melatonin), while others support relaxation, reduce nighttime anxiety, or help muscles and nerves relax (ashwagandha, magnesium).

  • Supplements are best used as part of an overall sleep routine: consistent bed and wake times, limiting evening light exposure (especially screens), avoiding heavy meals, alcohol or stimulants late in the day, and creating a calm bedroom environment.

  • When trying any sleep supplement, start low, try one change at a time, and give a few nights to assess effects before adding another product.

Melatonin

  • Melatonin is a hormone your body makes to signal nighttime. Taken as a supplement, it helps shift or reinforce your sleep-wake timing and is particularly useful when falling asleep is the main problem.

How to use it
  • Timing: take 30–60 minutes before your desired bedtime.

  • Dose: start with a very low dose—0.5–1 mg. If that has no effect after a few nights, increase cautiously up to 3 mg. Avoid routinely taking very high doses (for example, 10 mg), which are more likely to cause morning grogginess and other unwanted effects.

  • Use pattern: use melatonin as needed (for travel, shift work, or short periods of insomnia) rather than every night long-term when possible.

What to expect
  • Melatonin typically helps you fall asleep faster but does not reliably increase total sleep duration. Lower doses tend to be effective and reduce the risk of next-day drowsiness.

Safety and practical tips
  • Many over-the-counter products contain 3–10 mg. Read labels carefully and choose a low-dose formulation if possible.

  • If you need a third-party tested product, options that are commonly available include NOW Liquid Melatonin and single-milligram products such as Swanson Melatonin 1 mg; if you need 3 mg, chewable options such as Trader Joe’s Chewable Melatonin 3 mg or Solgar Melatonin 3 mg are commonly suggested.

  • Avoid combining melatonin with other sedating medications without medical advice. Discuss melatonin use with a healthcare provider if you are pregnant, breastfeeding, taking prescription medications, or have a chronic medical condition.

Ashwagandha

  • Ashwagandha is a plant-based adaptogen used to support relaxation, reduce nighttime anxiety, and improve sleep quality for some people. It is also taken for recovery and physical performance, although benefits for those uses are more modest and less consistent.

How to use it
  • Typical extract doses: 500–1,500 mg taken in the evening.

  • If using root powder rather than a standardized extract, higher amounts are often used (1,000 mg or more). Start at the lower end and adjust based on how you feel.

What to expect
  • Many people report improved sleep quality and reduced anxiety after a period of nightly use; effects tend to develop over several days to a few weeks.

Safety and practical tips
  • Side effects are uncommon but can include sleepiness, headache, stomach upset (nausea or diarrhea), and allergic reactions. In rare cases, liver injury has been reported; stop the supplement and seek care if you develop stomach pain, persistent nausea, unusual fatigue, or yellowing of the skin or eyes.

  • If you have known liver disease, are pregnant or breastfeeding, or take prescription medications, check with a healthcare professional before starting ashwagandha.

  • Third‑party tested options include Nature’s Way Standardized Ashwagandha Extract, GNC Herbal Plus Ashwagandha Extract, Organic India Ashwagandha Powder, and Solgar Ashwagandha Root Extract.

Magnesium

  • Magnesium is an essential mineral involved in hundreds of bodily processes. Adequate magnesium supports muscle and nerve function and can help nighttime relaxation and reduce cramps, restless legs, and some types of headache that interfere with sleep.

How to use it
  • Aim to meet the recommended dietary allowance through food plus supplement as needed (RDA roughly 420 mg for adult men and 320 mg for adult women). Many people take magnesium in the evening to support relaxation; typical supplemental amounts vary, often in the 100–400 mg range of elemental magnesium depending on the formulation.

  • Forms matter: some forms are gentler on the gut and better absorbed without laxative effects; others are more likely to cause diarrhea at higher doses.

Choosing a form
  • Magnesium bisglycinate, magnesium chloride, and magnesium glycerophosphate or taurinate are good options for improving body magnesium with minimal laxative effect.

  • Magnesium citrate, gluconate, or lactate are well absorbed but are more likely to cause loose stools at higher doses.

  • Magnesium oxide is inexpensive but more likely to upset the stomach and cause diarrhea.

  • Magnesium L‑threonate is more expensive, usually provides lower elemental magnesium, and is chosen by some for potential brain-related benefits, though it is less optimal if your primary goal is to raise overall magnesium stores.

Safety and practical tips
  • If your stool becomes loose, reduce the dose or change the form.

  • If you are on medications, especially certain blood pressure drugs or medications that affect kidney function, check with a healthcare professional before starting magnesium supplementation.

  • Third-party tested options include NOW Magnesium Glycinate, InnovixLabs Advanced Magnesium, Nutricology Magnesium Chloride Liquid, and SlowMag.

How to choose and combine supplements

  • Start with basics first: consistent sleep habits and lifestyle changes are the foundation. Add one supplement at a time so you can judge its effect.

  • If difficulty is primarily falling asleep or shifting sleep timing (travel/jet lag), try low-dose melatonin first.

  • If stress or nighttime anxiety keeps you awake, consider ashwagandha in the evening.

  • If muscle cramps, restless legs, or general relaxation is the issue—or your diet is low in magnesium—consider magnesium in the evening.

  • Be cautious combining several sedating supplements at once; together they can increase morning sleepiness. Give each product a trial of a few nights to a few weeks before changing dose or adding another.

When to seek medical advice

  • Stop a supplement and seek care if you develop severe gastrointestinal symptoms, jaundice (yellowing of skin/eyes), severe allergic reaction, or unusual persistent fatigue.

  • Check with a healthcare professional if you are pregnant, breastfeeding, have significant medical conditions (especially liver or kidney disease), or take prescription medications that could interact with supplements.

A practical plan to try

  • Week 1–2: focus on sleep behavior (consistent schedule, reduce screen time before bed, comfortable environment).

  • Week 3: if you still struggle, add one low-dose supplement based on your main problem (melatonin 0.5–1 mg 30–60 minutes before bed for sleep-onset; magnesium in the evening for relaxation or cramps; ashwagandha 500 mg in the evening for anxiety-driven sleep problems).

  • Monitor effects and side effects for 1–3 weeks. Adjust dose gradually if needed, and avoid long-term nightly melatonin unless advised by a clinician.

Conclusion

Melatonin, ashwagandha, and magnesium can each help different aspects of sleep when used thoughtfully. Start low, prioritize sleep habits, monitor how you feel, and choose products that are third-party tested when possible. If you have underlying health conditions or take prescription drugs, get tailored advice from a healthcare professional before starting a new supplement.

Join Mito Health’s annual membership to test 100+ biomarkers with concierge-level support from your care team.

Mito Health: Helping you live healthier, longer.

In-depth bloodwork & holistic health advice, backed by the latest longevity science. Only $399.

What could cost you $15,000? $349 with Mito.

No hidden fees. No subscription traps. Just real care.

What's included

Core Test - Comprehensive lab test covering 100+ biomarkers

Clinician reviewed insights and action plan

1:1 consultation with a real clinician

Upload past lab reports for lifetime tracking

Dedicated 1:1 health coaching

Duo Bundle (For 2)

Most popular

$798

$668

$130 off (17%)

Individual

$399

$349

$50 off (13%)

What could cost you $15,000? $349 with Mito.

No hidden fees. No subscription traps. Just real care.

What's included

Core Test - Comprehensive lab test covering 100+ biomarkers

Clinician reviewed insights and action plan

1:1 consultation with a real clinician

Upload past lab reports for lifetime tracking

Dedicated 1:1 health coaching

Duo Bundle (For 2)

Most popular

$798

$668

$130 off (17%)

Individual

$399

$349

$50 off (13%)

What could cost you $15,000? $349 with Mito.

No hidden fees. No subscription traps. Just real care.

What's included

Core Test - Comprehensive lab test covering 100+ biomarkers

Clinician reviewed insights and action plan

1:1 consultation with a real clinician

Upload past lab reports for lifetime tracking

Dedicated 1:1 health coaching

Duo Bundle (For 2)

Most popular

$798

$668

$130 off (17%)

Individual

$399

$349

$50 off (13%)

What could cost you $15,000? $349 with Mito.

No hidden fees. No subscription traps. Just real care.

Core Test - Comprehensive lab test covering 100+ biomarkers

Clinician reviewed insights and action plan

1:1 consultation with a real clinician

Upload past lab reports for lifetime tracking

Dedicated 1:1 health coaching

What's included

Duo Bundle (For 2)

Most popular

$798

$668

$130 off (17%)

Individual

$399

$349

$50 off (13%)

10x more value at a fraction of the walk-in price.

10x more value at a fraction of
the walk-in price.

10x more value at a fraction of the walk-in price.

10x more value at a fraction of the walk-in price.

The information provided by Mito Health is for improving your overall health and wellness only and is not intended to provide medical advice, diagnosis, or treatment. We engage the services of partner clinics authorised to order the tests and to receive your blood test results prior to making Mito Health analytics and recommendations available to you. These interactions are not intended to create, nor do they create, a doctor-patient relationship. You should seek the advice of a doctor or other qualified health provider with whom you have such a relationship if you are experiencing any symptoms of, or believe you may have, any medical or psychiatric condition. You should not ignore professional medical advice or delay in seeking it because of Mito Health recommendations or analysis. This service should not be used for medical diagnosis or treatment. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your clinician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your clinician or other qualified health provider.

The information provided by Mito Health is for improving your overall health and wellness only and is not intended to provide medical advice, diagnosis, or treatment. We engage the services of partner clinics authorised to order the tests and to receive your blood test results prior to making Mito Health analytics and recommendations available to you. These interactions are not intended to create, nor do they create, a doctor-patient relationship. You should seek the advice of a doctor or other qualified health provider with whom you have such a relationship if you are experiencing any symptoms of, or believe you may have, any medical or psychiatric condition. You should not ignore professional medical advice or delay in seeking it because of Mito Health recommendations or analysis. This service should not be used for medical diagnosis or treatment. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your clinician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your clinician or other qualified health provider.

The information provided by Mito Health is for improving your overall health and wellness only and is not intended to provide medical advice, diagnosis, or treatment. We engage the services of partner clinics authorised to order the tests and to receive your blood test results prior to making Mito Health analytics and recommendations available to you. These interactions are not intended to create, nor do they create, a doctor-patient relationship. You should seek the advice of a doctor or other qualified health provider with whom you have such a relationship if you are experiencing any symptoms of, or believe you may have, any medical or psychiatric condition. You should not ignore professional medical advice or delay in seeking it because of Mito Health recommendations or analysis. This service should not be used for medical diagnosis or treatment. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your clinician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your clinician or other qualified health provider.