Get a comprehensive health panel from $349.
Schedule online, results in a week
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David Sinclair Anti-Aging Protocol (2026): What It Is and What Science Says
A complete, science-backed breakdown of the David Sinclair protocol, including updated Sinclair supplements, dosages, and longevity strategies
Written by
Mito Health
A complete, science-backed breakdown of the David Sinclair protocol, including updated Sinclair supplements, dosages, and longevity strategies
Interest in longevity science continues to grow, and one of the most recognized figures in the field is David A. Sinclair. Sinclair, a professor at Harvard Medical School, has spent years studying why we age. He explores ways to slow or even partially reverse this process.
The David Sinclair Anti-Aging protocol blends lifestyle habits, nutrition strategies, and supplements. It aims to tackle the biological causes of aging. His work focuses on pathways like NAD+ metabolism and sirtuins, which play key roles in cellular repair and survival.
This guide explains the Sinclair anti-aging method. It also outlines the first steps to take before starting the updated Sinclair supplement protocol.
What Is the David Sinclair Protocol?
David Sinclair’s Anti-Aging Protocol activates the body’s natural longevity pathways through strategic nutrition and fasting, exercise, controlled stress, and targeted supplementation.
The core philosophy behind the protocol suggests that a loss of epigenetic information drives aging. Over time, cells lose their ability to regulate gene expression, resulting in dysfunction and disease.
Key Focus Areas of the Protocol:
Restoring cellular energy
Enhancing DNA repair
Activating survival pathways linked to longevity
The Science Behind Sinclair Anti-Aging Protocol
Sinclair’s work centers on the following key biological mechanisms:
NAD+ and Energy Decline: NAD+ is essential for energy production and DNA repair. These levels decline with age, contributing to fatigue and disease risk.
Sirtuins and Longevity Genes: Sirtuins help regulate inflammation, DNA repair, and metabolism. Metabolic stressors, such as fasting, activate them.
Epigenetic Aging: Changes in gene regulation over time lead to the loss of cellular identity. Sinclair’s research explores whether this process can be reversed.
These mechanisms show that aging is a controlled process. Both biology and the environment shape it, not time.
Sinclair Supplements for Longevity (Updated 2026 Stack)
The most talked-about part of the David Sinclair protocol is his supplement routine. The Sinclair supplements stack targets multiple hallmarks of aging:
Energy decline: NMN restores NAD+
Cellular damage: Resveratrol and ALA support repair
Inflammation: Omega-3s and aspirin help regulate it
Cellular cleanup: Spermidine and fisetin promote the removal of damaged cells
However, most of these interventions are still being tested in humans. While the strongest evidence for longevity currently supports lifestyle changes, the effects of these specific supplements remain promising but not definitive.
Core Supplements and Dosages
NMN (Nicotinamide Mononucleotide)
Dosage: ~1,000 mg (1 gram) daily in the morning
NMN is a precursor to NAD+, a critical molecule involved in energy production and DNA repair. NAD+ levels decline with age, which may impair cellular function over time.
Supplementing with NMN aims to restore NAD+ levels and support metabolic health. Early human studies suggest potential benefits in insulin sensitivity and muscle function, though long-term outcomes are still being studied. NMN is often considered a foundational component of the David Sinclair protocol.
Resveratrol
Dosage: ~1,000 mg (1 gram) daily (with fat)
Resveratrol is a plant compound found in grapes and red wine. It is known for its potential to activate sirtuins, proteins involved in cellular repair and longevity.
Because resveratrol is not easily absorbed, it is typically taken with fat to improve bioavailability. While animal studies show benefits for inflammation and cardiovascular health, human evidence remains limited and inconsistent.
Spermidine
Dosage: ~1–2 mg in the morning
Spermidine is a naturally occurring compound that supports autophagy, the process by which cells remove damaged components. This cellular cleanup process is essential for maintaining function as we age.
In addition to supplementation, spermidine can be obtained from foods such as mushrooms, soy products, and aged cheese. Dietary intake remains an important part of this strategy.
Supporting Vitamins
Trimethylglycine (TMG)
Dosage: 500–1,000 mg daily
TMG supports methylation, a key process involved in DNA regulation and cellular function. NAD+ boosters like NMN may increase the demand for methyl groups, so TMG helps maintain balance and prevent depletion.
Vitamin D3 & K2
Dosage: D3 - 4,000 to 5,000 IU, K2 - 180–360 mcg
Vitamin D supports bone health, immune function, and calcium regulation. Meanwhile, vitamin K2 helps direct calcium away from arteries and into bones.
Newer Additions to the Stack
Fisetin
Dosage: 500 mg daily
Also known as “The Zombie Cell Killer”, fisetin is a flavonoid found in fruits like strawberries. It is studied for its potential senolytic effects, meaning it may help clear senescent cells that accumulate with age and contribute to inflammation.
This area of research is still emerging, particularly in humans. While promising, its long-term impact remains under investigation.
Taurine
Dosage: 2,000 mg (2 grams) daily
Taurine has recently gained attention in longevity research. It plays a role in mitochondrial function, cardiovascular health, and metabolic regulation.
Recent studies suggest that taurine levels may decline with age and that restoring them could support healthy aging. This makes it one of the newer additions to the Sinclair supplement stack.
Prescription Medications
These are used under medical supervision and are not part of general self-guided protocols.
Metformin
Dosage: ~800–1,000 mg daily (evening)
Metformin is commonly used to manage blood sugar levels. It has also been studied for its potential to mimic calorie restriction and improve metabolic health by activating AMPK.
Some research suggests it may reduce the risk of age-related diseases, but it remains a prescription medication and should only be used under professional guidance.
Low-Dose Aspirin
Dosage: 81-83 mg
Low-dose aspirin may help reduce inflammation and support cardiovascular health in certain individuals. However, it is not universally recommended, as risks and benefits vary.
Rapamycin
Rapamycin targets the mTOR pathway, which regulates growth and aging. It mimics calorie restriction at a cellular level.
Sinclair uses rapamycin intermittently, but the dosage is undisclosed. Such use is still highly experimental and under clinical investigation.
Supplement | Typical Dosage (2026) | Primary Purpose | Notes |
NMN (Nicotinamide Mononucleotide) | ~1,000 mg | Boost NAD+ levels, support energy, and DNA repair | Often taken in the morning; foundational to the protocol |
Resveratrol | ~1,000 mg with fat | Activate sirtuins, support cellular defense | Fat improves absorption; human evidence is still limited |
Spermidine | ~1–2 mg | Promote autophagy (cellular cleanup) | Also found in foods like mushrooms and soy |
TMG (Trimethylglycine) | 500–1,000 mg | Support methylation | Helps offset methyl depletion from NAD+ boosters |
Vitamin D3 + K2 | D3: 4,000–5,000 IU; K2: 180–360 mcg | Bone, immune, cardiovascular support | K2 helps direct calcium properly |
Fisetin | ~500 mg | Senolytic (targets aging cells) | Still experimental in humans |
Taurine | ~2,000 mg | Mitochondrial and metabolic support | Newer addition based on emerging research |
Omega-3 (Fish Oil) | Varies | Reduce inflammation, support heart/brain | Provides EPA and DHA |
Metformin* | ~800–1,000 mg | Improve metabolic health, mimic calorie restriction | Prescription only; medical supervision required |
Low-Dose Aspirin* | ~81 mg | Reduce inflammation, support heart health | Not recommended for everyone |
Rapamycin* | Intermittent (varies) | Inhibit mTOR, mimic calorie restriction | Highly experimental; clinical supervision required |
*Prescription or experimental use only under medical supervision.
Diet and Fasting in the Sinclair Anti-Aging Approach
Diet is a foundational part of the Sinclair anti-aging framework. Rather than focusing on strict calorie counting, the emphasis is on timing, quality, and metabolic impact.
Time-restricted eating, often involving skipping breakfast, helps create periods where the body shifts from energy storage to repair. During these periods, processes like autophagy become more active.
A plant-forward diet rich in polyphenols supports cellular health by reducing oxidative stress and inflammation. Limiting sugar intake helps maintain stable blood glucose levels, which is important for metabolic health.
Moderate protein intake may also help regulate pathways like mTOR, which are linked to growth and aging. Together, these dietary strategies aim to create an internal environment that supports longevity.
Exercise and Lifestyle Habits
Exercise in the David Sinclair protocol is not about volume but intensity and adaptation.
Short bursts of high-intensity activity place controlled stress on the body. This type of stress can improve mitochondrial function, increase insulin sensitivity, and enhance overall resilience.
When combined with fasting, this creates a hormetic effect. Small, manageable stressors signal the body to strengthen its repair systems and improve efficiency.
Beyond exercise, lifestyle habits play a key role. Avoiding constant snacking, maintaining stable blood sugar, and prioritizing sleep all support long-term metabolic health.
What Science Supports vs. What Is Still Emerging
The David Sinclair protocol is grounded in established biological principles, but not all aspects have strong clinical evidence in humans.
Well-supported research shows that regular exercise, balanced nutrition, and maintaining metabolic health can improve lifespan and healthspan. Calorie restriction and fasting also show consistent benefits in animal studies and emerging human research.
At the same time, many supplements in the Sinclair stack, including NMN, resveratrol, and senolytics, are still being studied. Their long-term effects, optimal dosages, and real-world impact on aging remain areas of active research.
Understanding this distinction helps set realistic expectations and supports better decision-making.
The Takeaway
The David Sinclair protocol offers a forward-looking approach to aging by targeting the biology behind it. It combines lifestyle habits with targeted supplementation to support cellular function, reduce inflammation, and improve resilience.
The most practical takeaway is to prioritize proven strategies first. Nutrition, exercise, sleep, and metabolic health form the foundation of longevity. Supplements may play a supporting role, but they should be approached with informed caution.
Longevity starts with understanding your body. Before investing in supplements, it is important to understand how your body responds at a biological level.
Mito Health is here to help you jumpstart your journey to longevity with a comprehensive blood panel. Advanced biomarker testing helps you track inflammation, metabolic health, and biological age.
Instead of guessing which parts of the David Sinclair anti-aging approach apply to you, you can make data-driven decisions backed by real insights.
Frequently Asked Questions
What is the David Sinclair protocol?
The David Sinclair protocol is a longevity strategy that combines fasting, exercise, and supplements to target aging at the cellular level.
What supplements does David Sinclair take in 2026?
His updated stack includes NMN, resveratrol, metformin, spermidine, fisetin, taurine, omega-3s, vitamin D3, K2, and more.
Are Sinclair supplements safe?
Some are widely used, but others are experimental. It’s important to approach them carefully and seek professional guidance when needed.
Is NMN the most important supplement?
NMN is considered a core component because it supports NAD+, a key molecule in aging.
Can this protocol reverse aging?
Current evidence does not confirm reversal of aging in humans. Research is ongoing.
Resources
Palmer, R. D., Elnashar, M. M., & Vaccarezza, M. (2021). Precursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging. Aging medicine (Milton (N.S.W)), 4(3), 214–220. https://doi.org/10.1002/agm2.12170
Meng, Q., Li, J., Wang, C. et al. Biological function of resveratrol and its application in animal production: a review. J Animal Sci Biotechnol 14, 25 (2023). https://doi.org/10.1186/s40104-022-00822-z
Juliette Tavenier, Jan O. Nehlin, Morten Baltzer Houlind, Lene Juel Rasmussen, Tamara Tchkonia, James L. Kirkland, Ove Andersen, Line Jee Hartmann Rasmussen,
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases, Mechanisms of Aging and Development, Volume 222, 2024, 111995, ISSN 0047-6374, https://doi.org/10.1016/j.mad.2024.111995.
Parminder Singh et al., Taurine deficiency as a driver of aging.Science380,eabn9257(2023).DOI:10.1126/science.abn9257
Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., & Xiao, G. (2022). Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics, 12(6), 2722–2740. https://doi.org/10.7150/thno.71360
Related Articles
Get a comprehensive health panel from $349.
Schedule online, results in a week
Clear guidance, follow-up care available
HSA/FSA Eligible
Comments
Get a comprehensive health panel from $349.
Schedule online, results in a week
Clear guidance, follow-up care available
HSA/FSA Eligible
David Sinclair Anti-Aging Protocol (2026): What It Is and What Science Says
A complete, science-backed breakdown of the David Sinclair protocol, including updated Sinclair supplements, dosages, and longevity strategies
Written by
Mito Health
A complete, science-backed breakdown of the David Sinclair protocol, including updated Sinclair supplements, dosages, and longevity strategies
Interest in longevity science continues to grow, and one of the most recognized figures in the field is David A. Sinclair. Sinclair, a professor at Harvard Medical School, has spent years studying why we age. He explores ways to slow or even partially reverse this process.
The David Sinclair Anti-Aging protocol blends lifestyle habits, nutrition strategies, and supplements. It aims to tackle the biological causes of aging. His work focuses on pathways like NAD+ metabolism and sirtuins, which play key roles in cellular repair and survival.
This guide explains the Sinclair anti-aging method. It also outlines the first steps to take before starting the updated Sinclair supplement protocol.
What Is the David Sinclair Protocol?
David Sinclair’s Anti-Aging Protocol activates the body’s natural longevity pathways through strategic nutrition and fasting, exercise, controlled stress, and targeted supplementation.
The core philosophy behind the protocol suggests that a loss of epigenetic information drives aging. Over time, cells lose their ability to regulate gene expression, resulting in dysfunction and disease.
Key Focus Areas of the Protocol:
Restoring cellular energy
Enhancing DNA repair
Activating survival pathways linked to longevity
The Science Behind Sinclair Anti-Aging Protocol
Sinclair’s work centers on the following key biological mechanisms:
NAD+ and Energy Decline: NAD+ is essential for energy production and DNA repair. These levels decline with age, contributing to fatigue and disease risk.
Sirtuins and Longevity Genes: Sirtuins help regulate inflammation, DNA repair, and metabolism. Metabolic stressors, such as fasting, activate them.
Epigenetic Aging: Changes in gene regulation over time lead to the loss of cellular identity. Sinclair’s research explores whether this process can be reversed.
These mechanisms show that aging is a controlled process. Both biology and the environment shape it, not time.
Sinclair Supplements for Longevity (Updated 2026 Stack)
The most talked-about part of the David Sinclair protocol is his supplement routine. The Sinclair supplements stack targets multiple hallmarks of aging:
Energy decline: NMN restores NAD+
Cellular damage: Resveratrol and ALA support repair
Inflammation: Omega-3s and aspirin help regulate it
Cellular cleanup: Spermidine and fisetin promote the removal of damaged cells
However, most of these interventions are still being tested in humans. While the strongest evidence for longevity currently supports lifestyle changes, the effects of these specific supplements remain promising but not definitive.
Core Supplements and Dosages
NMN (Nicotinamide Mononucleotide)
Dosage: ~1,000 mg (1 gram) daily in the morning
NMN is a precursor to NAD+, a critical molecule involved in energy production and DNA repair. NAD+ levels decline with age, which may impair cellular function over time.
Supplementing with NMN aims to restore NAD+ levels and support metabolic health. Early human studies suggest potential benefits in insulin sensitivity and muscle function, though long-term outcomes are still being studied. NMN is often considered a foundational component of the David Sinclair protocol.
Resveratrol
Dosage: ~1,000 mg (1 gram) daily (with fat)
Resveratrol is a plant compound found in grapes and red wine. It is known for its potential to activate sirtuins, proteins involved in cellular repair and longevity.
Because resveratrol is not easily absorbed, it is typically taken with fat to improve bioavailability. While animal studies show benefits for inflammation and cardiovascular health, human evidence remains limited and inconsistent.
Spermidine
Dosage: ~1–2 mg in the morning
Spermidine is a naturally occurring compound that supports autophagy, the process by which cells remove damaged components. This cellular cleanup process is essential for maintaining function as we age.
In addition to supplementation, spermidine can be obtained from foods such as mushrooms, soy products, and aged cheese. Dietary intake remains an important part of this strategy.
Supporting Vitamins
Trimethylglycine (TMG)
Dosage: 500–1,000 mg daily
TMG supports methylation, a key process involved in DNA regulation and cellular function. NAD+ boosters like NMN may increase the demand for methyl groups, so TMG helps maintain balance and prevent depletion.
Vitamin D3 & K2
Dosage: D3 - 4,000 to 5,000 IU, K2 - 180–360 mcg
Vitamin D supports bone health, immune function, and calcium regulation. Meanwhile, vitamin K2 helps direct calcium away from arteries and into bones.
Newer Additions to the Stack
Fisetin
Dosage: 500 mg daily
Also known as “The Zombie Cell Killer”, fisetin is a flavonoid found in fruits like strawberries. It is studied for its potential senolytic effects, meaning it may help clear senescent cells that accumulate with age and contribute to inflammation.
This area of research is still emerging, particularly in humans. While promising, its long-term impact remains under investigation.
Taurine
Dosage: 2,000 mg (2 grams) daily
Taurine has recently gained attention in longevity research. It plays a role in mitochondrial function, cardiovascular health, and metabolic regulation.
Recent studies suggest that taurine levels may decline with age and that restoring them could support healthy aging. This makes it one of the newer additions to the Sinclair supplement stack.
Prescription Medications
These are used under medical supervision and are not part of general self-guided protocols.
Metformin
Dosage: ~800–1,000 mg daily (evening)
Metformin is commonly used to manage blood sugar levels. It has also been studied for its potential to mimic calorie restriction and improve metabolic health by activating AMPK.
Some research suggests it may reduce the risk of age-related diseases, but it remains a prescription medication and should only be used under professional guidance.
Low-Dose Aspirin
Dosage: 81-83 mg
Low-dose aspirin may help reduce inflammation and support cardiovascular health in certain individuals. However, it is not universally recommended, as risks and benefits vary.
Rapamycin
Rapamycin targets the mTOR pathway, which regulates growth and aging. It mimics calorie restriction at a cellular level.
Sinclair uses rapamycin intermittently, but the dosage is undisclosed. Such use is still highly experimental and under clinical investigation.
Supplement | Typical Dosage (2026) | Primary Purpose | Notes |
NMN (Nicotinamide Mononucleotide) | ~1,000 mg | Boost NAD+ levels, support energy, and DNA repair | Often taken in the morning; foundational to the protocol |
Resveratrol | ~1,000 mg with fat | Activate sirtuins, support cellular defense | Fat improves absorption; human evidence is still limited |
Spermidine | ~1–2 mg | Promote autophagy (cellular cleanup) | Also found in foods like mushrooms and soy |
TMG (Trimethylglycine) | 500–1,000 mg | Support methylation | Helps offset methyl depletion from NAD+ boosters |
Vitamin D3 + K2 | D3: 4,000–5,000 IU; K2: 180–360 mcg | Bone, immune, cardiovascular support | K2 helps direct calcium properly |
Fisetin | ~500 mg | Senolytic (targets aging cells) | Still experimental in humans |
Taurine | ~2,000 mg | Mitochondrial and metabolic support | Newer addition based on emerging research |
Omega-3 (Fish Oil) | Varies | Reduce inflammation, support heart/brain | Provides EPA and DHA |
Metformin* | ~800–1,000 mg | Improve metabolic health, mimic calorie restriction | Prescription only; medical supervision required |
Low-Dose Aspirin* | ~81 mg | Reduce inflammation, support heart health | Not recommended for everyone |
Rapamycin* | Intermittent (varies) | Inhibit mTOR, mimic calorie restriction | Highly experimental; clinical supervision required |
*Prescription or experimental use only under medical supervision.
Diet and Fasting in the Sinclair Anti-Aging Approach
Diet is a foundational part of the Sinclair anti-aging framework. Rather than focusing on strict calorie counting, the emphasis is on timing, quality, and metabolic impact.
Time-restricted eating, often involving skipping breakfast, helps create periods where the body shifts from energy storage to repair. During these periods, processes like autophagy become more active.
A plant-forward diet rich in polyphenols supports cellular health by reducing oxidative stress and inflammation. Limiting sugar intake helps maintain stable blood glucose levels, which is important for metabolic health.
Moderate protein intake may also help regulate pathways like mTOR, which are linked to growth and aging. Together, these dietary strategies aim to create an internal environment that supports longevity.
Exercise and Lifestyle Habits
Exercise in the David Sinclair protocol is not about volume but intensity and adaptation.
Short bursts of high-intensity activity place controlled stress on the body. This type of stress can improve mitochondrial function, increase insulin sensitivity, and enhance overall resilience.
When combined with fasting, this creates a hormetic effect. Small, manageable stressors signal the body to strengthen its repair systems and improve efficiency.
Beyond exercise, lifestyle habits play a key role. Avoiding constant snacking, maintaining stable blood sugar, and prioritizing sleep all support long-term metabolic health.
What Science Supports vs. What Is Still Emerging
The David Sinclair protocol is grounded in established biological principles, but not all aspects have strong clinical evidence in humans.
Well-supported research shows that regular exercise, balanced nutrition, and maintaining metabolic health can improve lifespan and healthspan. Calorie restriction and fasting also show consistent benefits in animal studies and emerging human research.
At the same time, many supplements in the Sinclair stack, including NMN, resveratrol, and senolytics, are still being studied. Their long-term effects, optimal dosages, and real-world impact on aging remain areas of active research.
Understanding this distinction helps set realistic expectations and supports better decision-making.
The Takeaway
The David Sinclair protocol offers a forward-looking approach to aging by targeting the biology behind it. It combines lifestyle habits with targeted supplementation to support cellular function, reduce inflammation, and improve resilience.
The most practical takeaway is to prioritize proven strategies first. Nutrition, exercise, sleep, and metabolic health form the foundation of longevity. Supplements may play a supporting role, but they should be approached with informed caution.
Longevity starts with understanding your body. Before investing in supplements, it is important to understand how your body responds at a biological level.
Mito Health is here to help you jumpstart your journey to longevity with a comprehensive blood panel. Advanced biomarker testing helps you track inflammation, metabolic health, and biological age.
Instead of guessing which parts of the David Sinclair anti-aging approach apply to you, you can make data-driven decisions backed by real insights.
Frequently Asked Questions
What is the David Sinclair protocol?
The David Sinclair protocol is a longevity strategy that combines fasting, exercise, and supplements to target aging at the cellular level.
What supplements does David Sinclair take in 2026?
His updated stack includes NMN, resveratrol, metformin, spermidine, fisetin, taurine, omega-3s, vitamin D3, K2, and more.
Are Sinclair supplements safe?
Some are widely used, but others are experimental. It’s important to approach them carefully and seek professional guidance when needed.
Is NMN the most important supplement?
NMN is considered a core component because it supports NAD+, a key molecule in aging.
Can this protocol reverse aging?
Current evidence does not confirm reversal of aging in humans. Research is ongoing.
Resources
Palmer, R. D., Elnashar, M. M., & Vaccarezza, M. (2021). Precursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging. Aging medicine (Milton (N.S.W)), 4(3), 214–220. https://doi.org/10.1002/agm2.12170
Meng, Q., Li, J., Wang, C. et al. Biological function of resveratrol and its application in animal production: a review. J Animal Sci Biotechnol 14, 25 (2023). https://doi.org/10.1186/s40104-022-00822-z
Juliette Tavenier, Jan O. Nehlin, Morten Baltzer Houlind, Lene Juel Rasmussen, Tamara Tchkonia, James L. Kirkland, Ove Andersen, Line Jee Hartmann Rasmussen,
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases, Mechanisms of Aging and Development, Volume 222, 2024, 111995, ISSN 0047-6374, https://doi.org/10.1016/j.mad.2024.111995.
Parminder Singh et al., Taurine deficiency as a driver of aging.Science380,eabn9257(2023).DOI:10.1126/science.abn9257
Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., & Xiao, G. (2022). Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics, 12(6), 2722–2740. https://doi.org/10.7150/thno.71360
Related Articles
Get a comprehensive health panel from $349.
Schedule online, results in a week
Clear guidance, follow-up care available
HSA/FSA Eligible
Comments
David Sinclair Anti-Aging Protocol (2026): What It Is and What Science Says
A complete, science-backed breakdown of the David Sinclair protocol, including updated Sinclair supplements, dosages, and longevity strategies
Written by
Mito Health
A complete, science-backed breakdown of the David Sinclair protocol, including updated Sinclair supplements, dosages, and longevity strategies
Interest in longevity science continues to grow, and one of the most recognized figures in the field is David A. Sinclair. Sinclair, a professor at Harvard Medical School, has spent years studying why we age. He explores ways to slow or even partially reverse this process.
The David Sinclair Anti-Aging protocol blends lifestyle habits, nutrition strategies, and supplements. It aims to tackle the biological causes of aging. His work focuses on pathways like NAD+ metabolism and sirtuins, which play key roles in cellular repair and survival.
This guide explains the Sinclair anti-aging method. It also outlines the first steps to take before starting the updated Sinclair supplement protocol.
What Is the David Sinclair Protocol?
David Sinclair’s Anti-Aging Protocol activates the body’s natural longevity pathways through strategic nutrition and fasting, exercise, controlled stress, and targeted supplementation.
The core philosophy behind the protocol suggests that a loss of epigenetic information drives aging. Over time, cells lose their ability to regulate gene expression, resulting in dysfunction and disease.
Key Focus Areas of the Protocol:
Restoring cellular energy
Enhancing DNA repair
Activating survival pathways linked to longevity
The Science Behind Sinclair Anti-Aging Protocol
Sinclair’s work centers on the following key biological mechanisms:
NAD+ and Energy Decline: NAD+ is essential for energy production and DNA repair. These levels decline with age, contributing to fatigue and disease risk.
Sirtuins and Longevity Genes: Sirtuins help regulate inflammation, DNA repair, and metabolism. Metabolic stressors, such as fasting, activate them.
Epigenetic Aging: Changes in gene regulation over time lead to the loss of cellular identity. Sinclair’s research explores whether this process can be reversed.
These mechanisms show that aging is a controlled process. Both biology and the environment shape it, not time.
Sinclair Supplements for Longevity (Updated 2026 Stack)
The most talked-about part of the David Sinclair protocol is his supplement routine. The Sinclair supplements stack targets multiple hallmarks of aging:
Energy decline: NMN restores NAD+
Cellular damage: Resveratrol and ALA support repair
Inflammation: Omega-3s and aspirin help regulate it
Cellular cleanup: Spermidine and fisetin promote the removal of damaged cells
However, most of these interventions are still being tested in humans. While the strongest evidence for longevity currently supports lifestyle changes, the effects of these specific supplements remain promising but not definitive.
Core Supplements and Dosages
NMN (Nicotinamide Mononucleotide)
Dosage: ~1,000 mg (1 gram) daily in the morning
NMN is a precursor to NAD+, a critical molecule involved in energy production and DNA repair. NAD+ levels decline with age, which may impair cellular function over time.
Supplementing with NMN aims to restore NAD+ levels and support metabolic health. Early human studies suggest potential benefits in insulin sensitivity and muscle function, though long-term outcomes are still being studied. NMN is often considered a foundational component of the David Sinclair protocol.
Resveratrol
Dosage: ~1,000 mg (1 gram) daily (with fat)
Resveratrol is a plant compound found in grapes and red wine. It is known for its potential to activate sirtuins, proteins involved in cellular repair and longevity.
Because resveratrol is not easily absorbed, it is typically taken with fat to improve bioavailability. While animal studies show benefits for inflammation and cardiovascular health, human evidence remains limited and inconsistent.
Spermidine
Dosage: ~1–2 mg in the morning
Spermidine is a naturally occurring compound that supports autophagy, the process by which cells remove damaged components. This cellular cleanup process is essential for maintaining function as we age.
In addition to supplementation, spermidine can be obtained from foods such as mushrooms, soy products, and aged cheese. Dietary intake remains an important part of this strategy.
Supporting Vitamins
Trimethylglycine (TMG)
Dosage: 500–1,000 mg daily
TMG supports methylation, a key process involved in DNA regulation and cellular function. NAD+ boosters like NMN may increase the demand for methyl groups, so TMG helps maintain balance and prevent depletion.
Vitamin D3 & K2
Dosage: D3 - 4,000 to 5,000 IU, K2 - 180–360 mcg
Vitamin D supports bone health, immune function, and calcium regulation. Meanwhile, vitamin K2 helps direct calcium away from arteries and into bones.
Newer Additions to the Stack
Fisetin
Dosage: 500 mg daily
Also known as “The Zombie Cell Killer”, fisetin is a flavonoid found in fruits like strawberries. It is studied for its potential senolytic effects, meaning it may help clear senescent cells that accumulate with age and contribute to inflammation.
This area of research is still emerging, particularly in humans. While promising, its long-term impact remains under investigation.
Taurine
Dosage: 2,000 mg (2 grams) daily
Taurine has recently gained attention in longevity research. It plays a role in mitochondrial function, cardiovascular health, and metabolic regulation.
Recent studies suggest that taurine levels may decline with age and that restoring them could support healthy aging. This makes it one of the newer additions to the Sinclair supplement stack.
Prescription Medications
These are used under medical supervision and are not part of general self-guided protocols.
Metformin
Dosage: ~800–1,000 mg daily (evening)
Metformin is commonly used to manage blood sugar levels. It has also been studied for its potential to mimic calorie restriction and improve metabolic health by activating AMPK.
Some research suggests it may reduce the risk of age-related diseases, but it remains a prescription medication and should only be used under professional guidance.
Low-Dose Aspirin
Dosage: 81-83 mg
Low-dose aspirin may help reduce inflammation and support cardiovascular health in certain individuals. However, it is not universally recommended, as risks and benefits vary.
Rapamycin
Rapamycin targets the mTOR pathway, which regulates growth and aging. It mimics calorie restriction at a cellular level.
Sinclair uses rapamycin intermittently, but the dosage is undisclosed. Such use is still highly experimental and under clinical investigation.
Supplement | Typical Dosage (2026) | Primary Purpose | Notes |
NMN (Nicotinamide Mononucleotide) | ~1,000 mg | Boost NAD+ levels, support energy, and DNA repair | Often taken in the morning; foundational to the protocol |
Resveratrol | ~1,000 mg with fat | Activate sirtuins, support cellular defense | Fat improves absorption; human evidence is still limited |
Spermidine | ~1–2 mg | Promote autophagy (cellular cleanup) | Also found in foods like mushrooms and soy |
TMG (Trimethylglycine) | 500–1,000 mg | Support methylation | Helps offset methyl depletion from NAD+ boosters |
Vitamin D3 + K2 | D3: 4,000–5,000 IU; K2: 180–360 mcg | Bone, immune, cardiovascular support | K2 helps direct calcium properly |
Fisetin | ~500 mg | Senolytic (targets aging cells) | Still experimental in humans |
Taurine | ~2,000 mg | Mitochondrial and metabolic support | Newer addition based on emerging research |
Omega-3 (Fish Oil) | Varies | Reduce inflammation, support heart/brain | Provides EPA and DHA |
Metformin* | ~800–1,000 mg | Improve metabolic health, mimic calorie restriction | Prescription only; medical supervision required |
Low-Dose Aspirin* | ~81 mg | Reduce inflammation, support heart health | Not recommended for everyone |
Rapamycin* | Intermittent (varies) | Inhibit mTOR, mimic calorie restriction | Highly experimental; clinical supervision required |
*Prescription or experimental use only under medical supervision.
Diet and Fasting in the Sinclair Anti-Aging Approach
Diet is a foundational part of the Sinclair anti-aging framework. Rather than focusing on strict calorie counting, the emphasis is on timing, quality, and metabolic impact.
Time-restricted eating, often involving skipping breakfast, helps create periods where the body shifts from energy storage to repair. During these periods, processes like autophagy become more active.
A plant-forward diet rich in polyphenols supports cellular health by reducing oxidative stress and inflammation. Limiting sugar intake helps maintain stable blood glucose levels, which is important for metabolic health.
Moderate protein intake may also help regulate pathways like mTOR, which are linked to growth and aging. Together, these dietary strategies aim to create an internal environment that supports longevity.
Exercise and Lifestyle Habits
Exercise in the David Sinclair protocol is not about volume but intensity and adaptation.
Short bursts of high-intensity activity place controlled stress on the body. This type of stress can improve mitochondrial function, increase insulin sensitivity, and enhance overall resilience.
When combined with fasting, this creates a hormetic effect. Small, manageable stressors signal the body to strengthen its repair systems and improve efficiency.
Beyond exercise, lifestyle habits play a key role. Avoiding constant snacking, maintaining stable blood sugar, and prioritizing sleep all support long-term metabolic health.
What Science Supports vs. What Is Still Emerging
The David Sinclair protocol is grounded in established biological principles, but not all aspects have strong clinical evidence in humans.
Well-supported research shows that regular exercise, balanced nutrition, and maintaining metabolic health can improve lifespan and healthspan. Calorie restriction and fasting also show consistent benefits in animal studies and emerging human research.
At the same time, many supplements in the Sinclair stack, including NMN, resveratrol, and senolytics, are still being studied. Their long-term effects, optimal dosages, and real-world impact on aging remain areas of active research.
Understanding this distinction helps set realistic expectations and supports better decision-making.
The Takeaway
The David Sinclair protocol offers a forward-looking approach to aging by targeting the biology behind it. It combines lifestyle habits with targeted supplementation to support cellular function, reduce inflammation, and improve resilience.
The most practical takeaway is to prioritize proven strategies first. Nutrition, exercise, sleep, and metabolic health form the foundation of longevity. Supplements may play a supporting role, but they should be approached with informed caution.
Longevity starts with understanding your body. Before investing in supplements, it is important to understand how your body responds at a biological level.
Mito Health is here to help you jumpstart your journey to longevity with a comprehensive blood panel. Advanced biomarker testing helps you track inflammation, metabolic health, and biological age.
Instead of guessing which parts of the David Sinclair anti-aging approach apply to you, you can make data-driven decisions backed by real insights.
Frequently Asked Questions
What is the David Sinclair protocol?
The David Sinclair protocol is a longevity strategy that combines fasting, exercise, and supplements to target aging at the cellular level.
What supplements does David Sinclair take in 2026?
His updated stack includes NMN, resveratrol, metformin, spermidine, fisetin, taurine, omega-3s, vitamin D3, K2, and more.
Are Sinclair supplements safe?
Some are widely used, but others are experimental. It’s important to approach them carefully and seek professional guidance when needed.
Is NMN the most important supplement?
NMN is considered a core component because it supports NAD+, a key molecule in aging.
Can this protocol reverse aging?
Current evidence does not confirm reversal of aging in humans. Research is ongoing.
Resources
Palmer, R. D., Elnashar, M. M., & Vaccarezza, M. (2021). Precursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging. Aging medicine (Milton (N.S.W)), 4(3), 214–220. https://doi.org/10.1002/agm2.12170
Meng, Q., Li, J., Wang, C. et al. Biological function of resveratrol and its application in animal production: a review. J Animal Sci Biotechnol 14, 25 (2023). https://doi.org/10.1186/s40104-022-00822-z
Juliette Tavenier, Jan O. Nehlin, Morten Baltzer Houlind, Lene Juel Rasmussen, Tamara Tchkonia, James L. Kirkland, Ove Andersen, Line Jee Hartmann Rasmussen,
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases, Mechanisms of Aging and Development, Volume 222, 2024, 111995, ISSN 0047-6374, https://doi.org/10.1016/j.mad.2024.111995.
Parminder Singh et al., Taurine deficiency as a driver of aging.Science380,eabn9257(2023).DOI:10.1126/science.abn9257
Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., & Xiao, G. (2022). Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics, 12(6), 2722–2740. https://doi.org/10.7150/thno.71360
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David Sinclair Anti-Aging Protocol (2026): What It Is and What Science Says
A complete, science-backed breakdown of the David Sinclair protocol, including updated Sinclair supplements, dosages, and longevity strategies
Written by
Mito Health
A complete, science-backed breakdown of the David Sinclair protocol, including updated Sinclair supplements, dosages, and longevity strategies
Interest in longevity science continues to grow, and one of the most recognized figures in the field is David A. Sinclair. Sinclair, a professor at Harvard Medical School, has spent years studying why we age. He explores ways to slow or even partially reverse this process.
The David Sinclair Anti-Aging protocol blends lifestyle habits, nutrition strategies, and supplements. It aims to tackle the biological causes of aging. His work focuses on pathways like NAD+ metabolism and sirtuins, which play key roles in cellular repair and survival.
This guide explains the Sinclair anti-aging method. It also outlines the first steps to take before starting the updated Sinclair supplement protocol.
What Is the David Sinclair Protocol?
David Sinclair’s Anti-Aging Protocol activates the body’s natural longevity pathways through strategic nutrition and fasting, exercise, controlled stress, and targeted supplementation.
The core philosophy behind the protocol suggests that a loss of epigenetic information drives aging. Over time, cells lose their ability to regulate gene expression, resulting in dysfunction and disease.
Key Focus Areas of the Protocol:
Restoring cellular energy
Enhancing DNA repair
Activating survival pathways linked to longevity
The Science Behind Sinclair Anti-Aging Protocol
Sinclair’s work centers on the following key biological mechanisms:
NAD+ and Energy Decline: NAD+ is essential for energy production and DNA repair. These levels decline with age, contributing to fatigue and disease risk.
Sirtuins and Longevity Genes: Sirtuins help regulate inflammation, DNA repair, and metabolism. Metabolic stressors, such as fasting, activate them.
Epigenetic Aging: Changes in gene regulation over time lead to the loss of cellular identity. Sinclair’s research explores whether this process can be reversed.
These mechanisms show that aging is a controlled process. Both biology and the environment shape it, not time.
Sinclair Supplements for Longevity (Updated 2026 Stack)
The most talked-about part of the David Sinclair protocol is his supplement routine. The Sinclair supplements stack targets multiple hallmarks of aging:
Energy decline: NMN restores NAD+
Cellular damage: Resveratrol and ALA support repair
Inflammation: Omega-3s and aspirin help regulate it
Cellular cleanup: Spermidine and fisetin promote the removal of damaged cells
However, most of these interventions are still being tested in humans. While the strongest evidence for longevity currently supports lifestyle changes, the effects of these specific supplements remain promising but not definitive.
Core Supplements and Dosages
NMN (Nicotinamide Mononucleotide)
Dosage: ~1,000 mg (1 gram) daily in the morning
NMN is a precursor to NAD+, a critical molecule involved in energy production and DNA repair. NAD+ levels decline with age, which may impair cellular function over time.
Supplementing with NMN aims to restore NAD+ levels and support metabolic health. Early human studies suggest potential benefits in insulin sensitivity and muscle function, though long-term outcomes are still being studied. NMN is often considered a foundational component of the David Sinclair protocol.
Resveratrol
Dosage: ~1,000 mg (1 gram) daily (with fat)
Resveratrol is a plant compound found in grapes and red wine. It is known for its potential to activate sirtuins, proteins involved in cellular repair and longevity.
Because resveratrol is not easily absorbed, it is typically taken with fat to improve bioavailability. While animal studies show benefits for inflammation and cardiovascular health, human evidence remains limited and inconsistent.
Spermidine
Dosage: ~1–2 mg in the morning
Spermidine is a naturally occurring compound that supports autophagy, the process by which cells remove damaged components. This cellular cleanup process is essential for maintaining function as we age.
In addition to supplementation, spermidine can be obtained from foods such as mushrooms, soy products, and aged cheese. Dietary intake remains an important part of this strategy.
Supporting Vitamins
Trimethylglycine (TMG)
Dosage: 500–1,000 mg daily
TMG supports methylation, a key process involved in DNA regulation and cellular function. NAD+ boosters like NMN may increase the demand for methyl groups, so TMG helps maintain balance and prevent depletion.
Vitamin D3 & K2
Dosage: D3 - 4,000 to 5,000 IU, K2 - 180–360 mcg
Vitamin D supports bone health, immune function, and calcium regulation. Meanwhile, vitamin K2 helps direct calcium away from arteries and into bones.
Newer Additions to the Stack
Fisetin
Dosage: 500 mg daily
Also known as “The Zombie Cell Killer”, fisetin is a flavonoid found in fruits like strawberries. It is studied for its potential senolytic effects, meaning it may help clear senescent cells that accumulate with age and contribute to inflammation.
This area of research is still emerging, particularly in humans. While promising, its long-term impact remains under investigation.
Taurine
Dosage: 2,000 mg (2 grams) daily
Taurine has recently gained attention in longevity research. It plays a role in mitochondrial function, cardiovascular health, and metabolic regulation.
Recent studies suggest that taurine levels may decline with age and that restoring them could support healthy aging. This makes it one of the newer additions to the Sinclair supplement stack.
Prescription Medications
These are used under medical supervision and are not part of general self-guided protocols.
Metformin
Dosage: ~800–1,000 mg daily (evening)
Metformin is commonly used to manage blood sugar levels. It has also been studied for its potential to mimic calorie restriction and improve metabolic health by activating AMPK.
Some research suggests it may reduce the risk of age-related diseases, but it remains a prescription medication and should only be used under professional guidance.
Low-Dose Aspirin
Dosage: 81-83 mg
Low-dose aspirin may help reduce inflammation and support cardiovascular health in certain individuals. However, it is not universally recommended, as risks and benefits vary.
Rapamycin
Rapamycin targets the mTOR pathway, which regulates growth and aging. It mimics calorie restriction at a cellular level.
Sinclair uses rapamycin intermittently, but the dosage is undisclosed. Such use is still highly experimental and under clinical investigation.
Supplement | Typical Dosage (2026) | Primary Purpose | Notes |
NMN (Nicotinamide Mononucleotide) | ~1,000 mg | Boost NAD+ levels, support energy, and DNA repair | Often taken in the morning; foundational to the protocol |
Resveratrol | ~1,000 mg with fat | Activate sirtuins, support cellular defense | Fat improves absorption; human evidence is still limited |
Spermidine | ~1–2 mg | Promote autophagy (cellular cleanup) | Also found in foods like mushrooms and soy |
TMG (Trimethylglycine) | 500–1,000 mg | Support methylation | Helps offset methyl depletion from NAD+ boosters |
Vitamin D3 + K2 | D3: 4,000–5,000 IU; K2: 180–360 mcg | Bone, immune, cardiovascular support | K2 helps direct calcium properly |
Fisetin | ~500 mg | Senolytic (targets aging cells) | Still experimental in humans |
Taurine | ~2,000 mg | Mitochondrial and metabolic support | Newer addition based on emerging research |
Omega-3 (Fish Oil) | Varies | Reduce inflammation, support heart/brain | Provides EPA and DHA |
Metformin* | ~800–1,000 mg | Improve metabolic health, mimic calorie restriction | Prescription only; medical supervision required |
Low-Dose Aspirin* | ~81 mg | Reduce inflammation, support heart health | Not recommended for everyone |
Rapamycin* | Intermittent (varies) | Inhibit mTOR, mimic calorie restriction | Highly experimental; clinical supervision required |
*Prescription or experimental use only under medical supervision.
Diet and Fasting in the Sinclair Anti-Aging Approach
Diet is a foundational part of the Sinclair anti-aging framework. Rather than focusing on strict calorie counting, the emphasis is on timing, quality, and metabolic impact.
Time-restricted eating, often involving skipping breakfast, helps create periods where the body shifts from energy storage to repair. During these periods, processes like autophagy become more active.
A plant-forward diet rich in polyphenols supports cellular health by reducing oxidative stress and inflammation. Limiting sugar intake helps maintain stable blood glucose levels, which is important for metabolic health.
Moderate protein intake may also help regulate pathways like mTOR, which are linked to growth and aging. Together, these dietary strategies aim to create an internal environment that supports longevity.
Exercise and Lifestyle Habits
Exercise in the David Sinclair protocol is not about volume but intensity and adaptation.
Short bursts of high-intensity activity place controlled stress on the body. This type of stress can improve mitochondrial function, increase insulin sensitivity, and enhance overall resilience.
When combined with fasting, this creates a hormetic effect. Small, manageable stressors signal the body to strengthen its repair systems and improve efficiency.
Beyond exercise, lifestyle habits play a key role. Avoiding constant snacking, maintaining stable blood sugar, and prioritizing sleep all support long-term metabolic health.
What Science Supports vs. What Is Still Emerging
The David Sinclair protocol is grounded in established biological principles, but not all aspects have strong clinical evidence in humans.
Well-supported research shows that regular exercise, balanced nutrition, and maintaining metabolic health can improve lifespan and healthspan. Calorie restriction and fasting also show consistent benefits in animal studies and emerging human research.
At the same time, many supplements in the Sinclair stack, including NMN, resveratrol, and senolytics, are still being studied. Their long-term effects, optimal dosages, and real-world impact on aging remain areas of active research.
Understanding this distinction helps set realistic expectations and supports better decision-making.
The Takeaway
The David Sinclair protocol offers a forward-looking approach to aging by targeting the biology behind it. It combines lifestyle habits with targeted supplementation to support cellular function, reduce inflammation, and improve resilience.
The most practical takeaway is to prioritize proven strategies first. Nutrition, exercise, sleep, and metabolic health form the foundation of longevity. Supplements may play a supporting role, but they should be approached with informed caution.
Longevity starts with understanding your body. Before investing in supplements, it is important to understand how your body responds at a biological level.
Mito Health is here to help you jumpstart your journey to longevity with a comprehensive blood panel. Advanced biomarker testing helps you track inflammation, metabolic health, and biological age.
Instead of guessing which parts of the David Sinclair anti-aging approach apply to you, you can make data-driven decisions backed by real insights.
Frequently Asked Questions
What is the David Sinclair protocol?
The David Sinclair protocol is a longevity strategy that combines fasting, exercise, and supplements to target aging at the cellular level.
What supplements does David Sinclair take in 2026?
His updated stack includes NMN, resveratrol, metformin, spermidine, fisetin, taurine, omega-3s, vitamin D3, K2, and more.
Are Sinclair supplements safe?
Some are widely used, but others are experimental. It’s important to approach them carefully and seek professional guidance when needed.
Is NMN the most important supplement?
NMN is considered a core component because it supports NAD+, a key molecule in aging.
Can this protocol reverse aging?
Current evidence does not confirm reversal of aging in humans. Research is ongoing.
Resources
Palmer, R. D., Elnashar, M. M., & Vaccarezza, M. (2021). Precursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging. Aging medicine (Milton (N.S.W)), 4(3), 214–220. https://doi.org/10.1002/agm2.12170
Meng, Q., Li, J., Wang, C. et al. Biological function of resveratrol and its application in animal production: a review. J Animal Sci Biotechnol 14, 25 (2023). https://doi.org/10.1186/s40104-022-00822-z
Juliette Tavenier, Jan O. Nehlin, Morten Baltzer Houlind, Lene Juel Rasmussen, Tamara Tchkonia, James L. Kirkland, Ove Andersen, Line Jee Hartmann Rasmussen,
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases, Mechanisms of Aging and Development, Volume 222, 2024, 111995, ISSN 0047-6374, https://doi.org/10.1016/j.mad.2024.111995.
Parminder Singh et al., Taurine deficiency as a driver of aging.Science380,eabn9257(2023).DOI:10.1126/science.abn9257
Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., & Xiao, G. (2022). Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics, 12(6), 2722–2740. https://doi.org/10.7150/thno.71360
Related Articles
Get a comprehensive health panel from $349.
Schedule online, results in a week
Clear guidance, follow-up care available
HSA/FSA Eligible
Get a comprehensive health panel from $349.
Schedule online, results in a week
Clear guidance, follow-up care available
HSA/FSA Eligible
Comments
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Checkout with HSA/FSA
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What's included
1 Comprehensive lab test with over 100+ biomarkers
One appointment, test at 2,000+ labs nationwide
Insights calibrated to your biology
Recommendations informed by your ethnicity, lifestyle, and history. Not generic ranges.
1:1 Consultation
Meet with your dedicated care team to review your results and define next steps
Lifetime health record tracking
Upload past labs and monitor your progress over time
Biological age analysis
See how your body is aging and what’s driving it
Order add-on tests and scans anytime
Access to advanced diagnostics at discounted rates for members
Concierge-level care, made accessible.
Mito Health Membership
Codeveloped with experts at MIT & Stanford
Less than $1/ day
Billed annually - cancel anytime
Bundle options:
Individual
$399
$349
/year
or 4 interest-free payments of $87.25*
Duo Bundle (For 2)
$798
$660
/year
or 4 interest-free payments of $167*
Pricing for members in NY, NJ & RI may vary.
Checkout with HSA/FSA
Secure, private platform
What's included
1 Comprehensive lab test with over 100+ biomarkers
One appointment, test at 2,000+ labs nationwide
Insights calibrated to your biology
Recommendations informed by your ethnicity, lifestyle, and history. Not generic ranges.
1:1 Consultation
Meet with your dedicated care team to review your results and define next steps
Lifetime health record tracking
Upload past labs and monitor your progress over time
Biological age analysis
See how your body is aging and what’s driving it
Order add-on tests and scans anytime
Access to advanced diagnostics at discounted rates for members
Concierge-level care, made accessible.
Mito Health Membership
Codeveloped with experts at MIT & Stanford
Less than $1/ day
Billed annually - cancel anytime
Bundle options:
Individual
$399
$349
/year
or 4 payments of $87.25*
Duo Bundle
(For 2)
$798
$660
/year
or 4 payments of $167*
Pricing for members in NY, NJ & RI may vary.
Checkout with HSA/FSA
Secure, private platform