What is Cystatin C?

Cystatin C is a small protein found throughout our entire body and is also filtered out through the kidneys. It is not affected by diet or muscle mass but can be affected in obesity, low thyroid hormones and when certain medications are used.‍Measuring kidney function with both creatinine and cystatin C thus provides a more accurate estimate of kidney function.

What does it assess?

Cystatin C is a protein produced by all cells in the body, and it is involved in the regulation of enzymes that break down proteins.‍It is primarily used as a marker to assess kidney function, as it is filtered by the kidneys and is less affected by factors like muscle mass or hydration status compared to creatinine.‍Cystatin C levels are commonly used to estimate glomerular filtration rate (GFR) and provide a more accurate picture of kidney health, particularly in individuals with abnormal muscle mass or other conditions that may skew creatinine levels.

How do I optimize my Cystatin C levels?

Proper hydration is essential for optimal kidney function. Drinking adequate water throughout the day helps kidneys filter waste, including cystatin C, more efficiently.‍Avoid dehydration, as it can artificially elevate cystatin C levels and stress the kidneys. Chronic hypertension can lead to kidney damage over time, contributing to elevated cystatin C levels.‍By managing blood pressure through lifestyle modifications like reducing sodium intake, regular exercise, and stress management, you can protect kidney function. A diet rich in fruits, vegetables, whole grains, and lean proteins helps reduce kidney strain.‍Reducing your intake of processed foods, excess salt, and high-protein diets can also help protect kidney health and prevent cystatin C from rising.

What do high and low Cystatin C levels mean?

Elevated cystatin C levels typically indicate a decline in kidney function, as the kidneys are less efficient at filtering the protein out of the bloodstream.‍High levels can be seen in conditions such as chronic kidney disease (CKD), acute kidney injury, or other forms of kidney dysfunction.‍Low cystatin C levels are not typically a cause for concern and are relatively uncommon.