What is Creatinine?

Creatinine (not to be confused with creatine) is a chemical primarily produced by skeletal muscle or taken in the diet.‍It is used to estimate kidney filtering function. As it is produced at a relatively constant rate, changes in blood levels of creatinine are typically related to changes in the rate it is cleared from the body by the kidneys.

What does it assess?

Creatinine is primarily filtered out of the bloodstream by the kidneys, so creatinine levels in the blood are an important indicator of kidney function.‍A serum creatinine test is commonly used to assess kidney health, with higher levels often indicating impaired kidney function.‍It is an essential marker for diagnosing and monitoring kidney diseases, such as chronic kidney disease (CKD), and helps estimate glomerular filtration rate (GFR), a key indicator of kidney performance.

How do I optimize my Creatinine levels?

Adequate hydration supports kidney function and helps ensure proper filtration of waste products, including creatinine.‍Aim to drink plenty of water throughout the day, adjusting for activity level and climate.‍Dehydration can lead to falsely elevated creatinine levels, as it reduces kidney efficiency. While protein is essential for muscle health, excessive protein consumption can increase creatinine levels, as the body produces more waste products when metabolizing protein.‍Aim for a balanced diet with moderate protein intake, and focus on plant-based sources or lean proteins, if needed, to reduce the strain on kidneys. Creatine supplements can raise creatinine levels as they increase creatine breakdown in muscles.‍If you're using creatine for performance, follow recommended dosages to ensure it’s safe, especially if you have any risk factors for kidney disease.

What do high and low Creatinine levels mean?

Elevated creatinine levels typically suggest impaired kidney function. This could indicate conditions such as chronic kidney disease (CKD), acute kidney injury, dehydration, or kidney infections.‍When creatinine is elevated, it is important to assess other markers, such as glomerular filtration rate (GFR) and urine protein, to determine the extent of kidney damage.‍Low creatinine levels are less common but may occur in individuals with very low muscle mass, malnutrition, or certain medical conditions that affect muscle breakdown.