What is Unsaturated Iron Binding Capacity (UIBC)?

Unsaturated Iron-Binding Capacity (UIBC) is part of a iron studies test that help evaluate iron stores.‍UIBC measures the reserve capacity of transferrin, a protein that transports iron in the blood, to bind with iron.

What does it assess?

As part of an iron panel, UIBC is interpreted in conjunction with iron, TIBC, and iron saturation levels to provide an assessment of your body's iron status.

How do I optimize my Unsaturated Iron Binding Capacity (UIBC) levels?

Maintain an adequate intake of dietary iron through both heme and non-heme iron.‍Heme iron is more readily absorbed, but balancing both types can help avoid excessive intake. Vitamin C improves non-heme iron absorption, especially beneficial when iron levels are low and UIBC is high.‍Include vitamin C-rich foods like citrus fruits, bell peppers, and broccoli with meals. UIBC depends on transferrin, a protein that binds to iron.‍Ensure adequate protein intake, especially from high-quality sources like lean meats, eggs, dairy, and legumes, to support transferrin production and optimal UIBC levels.

What do high and low Unsaturated Iron Binding Capacity (UIBC) levels mean?

High UIBC indicates that a lot of transferrin is available in the blood to bind to iron, suggesting low iron levels in the blood. This is a clue that suggests iron deficiency, even at mild levels where red blood cell biomarkers have not yet been affected.‍Low UIBC indicates that less transferrin is available to bind to iron, suggesting adequate or high iron levels in the blood.‍