What is Sex Hormone Binding Globulin (SHBG)?

Sex Hormone Binding Globulin (SHBG) is a glycoprotein produced primarily in the liver.‍SHBG binds to sex hormones, specifically testosterone and estrogen, in the bloodstream, regulating their bioavailability and activity by transporting them to target tissues. When bound to SHBG, these hormones are inactive, and only the unbound or "free" hormones are available to exert effects on tissues.‍SHBG plays a crucial role in maintaining hormonal balance by controlling the levels of active sex hormones in the body.

What does it assess?

SHBG levels provide insights into an individual's hormonal health and balance.‍This test is often used to evaluate androgen and estrogen levels indirectly, as changes in SHBG can affect the balance of active testosterone and estrogen.‍By measuring SHBG, healthcare providers can gain a clearer picture of hormonal status, particularly in cases of suspected androgen or estrogen imbalance.

How do I optimize my Sex Hormone Binding Globulin (SHBG) levels?

High insulin levels can suppress SHBG production, leading to lower SHBG and increased free testosterone.‍Regular physical activity, a balanced diet rich in fiber and low in refined sugars, and maintaining a healthy weight can improve insulin sensitivity and potentially raise SHBG. Since SHBG is produced in the liver, supporting liver health can help regulate SHBG levels.‍This includes minimizing alcohol intake, avoiding processed foods high in saturated fats, and incorporating liver-supportive nutrients like antioxidants and leafy greens to assist detoxification.‍ Foods rich in phytoestrogens may positively influence SHBG levels by modulating estrogen levels.‍Healthy fats, such as omega-3 fatty acids from fish or flaxseed, can also support overall hormonal balance and SHBG regulation.

What do high and low levels of Sex Hormone Binding Globulin (SHBG) mean?

Elevated SHBG may lead to lower levels of free testosterone and estrogen.‍In men, this can result in symptoms such as reduced muscle mass, fatigue, and low libido. In women, high SHBG can lead to symptoms of estrogen deficiency, including irregular menstrual cycles or reduced bone density.‍Low SHBG increases the levels of free, active hormones like testosterone and estrogen.‍In both men and women, low SHBG can be associated with insulin resistance, obesity, and type 2 diabetes. Low SHBG may also be linked to hypothyroidism and Cushing's syndrome.

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