MCV: A Key Indicator of Blood Health & Oxygen Delivery

What is MCV?

Mean corpuscular volume (MCV) is a measurement of the average volume or size of red blood cells. This gauge is useful in assessing the well-being of red blood cells and in states of anemia (low haemoglobin), gives us important clues to identify the underlying cause.‍Optimal levels of iron, folate and B12 are commonly reflected by a healthy MCV, while certain blood disorders and chronic diseases can adversely affect MCV.

What does it assess?

Mean Corpuscular Volume (MCV) provides insight into the type of anemia a person may have and helps assess red blood cell health. Normal MCV, along with other blood indices, may indicate a balanced red blood cell production process.

How do I optimize my MCV?

For low MCV linked to iron deficiency anemia, maintaining adequate iron intake is essential. Include iron-rich foods like lean meats, leafy greens, and fortified grains. Low levels of B12 and folate are common causes of high MCV. Foods rich in B12, such as meat, dairy, and eggs, and folate sources like leafy greens, beans, and citrus fruits, help reduce macrocytosis. Excessive alcohol intake can interfere with nutrient absorption, especially B vitamins, and damage red blood cells, contributing to high MCV.‍Reducing alcohol can help normalize red blood cell size and promote overall blood health.

What does a high and low MCV mean?

Elevated MCV often indicates that red blood cells are larger than normal, commonly due to deficiencies in vitamin B12 or folate.‍Other causes may include liver disease, hypothyroidism, or alcohol use, which can impair nutrient absorption or damage cells.‍Low MCV suggests microcytosis, where red blood cells are smaller than normal.‍This is often linked to iron deficiency anemia, chronic inflammation, or certain genetic conditions like thalassaemia. Symptoms may include fatigue, pale skin, and dizziness, as low MCV typically indicates reduced oxygen-carrying capacity.