What is DHEA-Sulfate (DHEA-S)?

DHEA-Sulfate (DHEA-S) is a sulfated form of dehydroepiandrosterone (DHEA), a hormone primarily produced by the adrenal glands.‍DHEA-S serves as a precursor to male and female sex hormones, such as testosterone and estrogen.‍It plays a significant role in supporting immune function, bone health, and mood regulation, and its levels decline with age, starting in young adulthood.

What does it assess?

DHEA-S levels help assess adrenal gland function and androgen production in both men and women.‍Testing DHEA-S can assist in evaluating the cause of symptoms like fatigue, low libido, and hormonal imbalances.‍In women, high DHEA-S levels may indicate conditions like polycystic ovary syndrome (PCOS) or adrenal hyperplasia, while in men, abnormal DHEA-S levels can provide insight into issues related to adrenal health and hormone balance.

How do I optimize my DHEA-Sulfate (DHEA-S) levels?

Chronic stress can reduce DHEA-S production by overtaxing the adrenal glands. Incorporating stress-reduction techniques, like mindfulness, meditation, and regular physical activity, can support adrenal health and help maintain balanced DHEA-S levels. Quality sleep is essential for hormone regulation, including DHEA-S.‍Aim for 7 to 9 hours of restful sleep per night to help support balanced adrenal and hormone function. Nutrients like vitamin C, magnesium, and adaptogenic herbs (such as ashwagandha and rhodiola) can support adrenal function and may promote healthy DHEA-S levels.‍Consulting with a healthcare provider before starting any supplements is recommended.

What do high and low DHEA-Sulfate (DHEA-S) levels mean?

Elevated DHEA-S levels may indicate overactive adrenal glands or conditions like polycystic ovary syndrome (PCOS) and adrenal tumors.‍In women, high DHEA-S may cause symptoms such as excessive hair growth (hirsutism), acne, and irregular menstrual cycles. In both genders, excessively high levels may also contribute to anxiety or aggression.‍Low DHEA-S levels can be a sign of adrenal insufficiency, which may result from chronic stress, aging, or certain autoimmune conditions.‍Symptoms associated with low DHEA-S levels include fatigue, low libido, decreased bone density, and mood changes such as depression or anxiety. Low levels may also be linked to a reduced capacity to handle physical and emotional stress.