Mar 20, 2025
Omega-3 and Depression: Could Your Mood Swings Be a Nutrient Deficiency?
Emerging research links low omega-3 levels to anxiety, depression, and cognitive decline. If you’ve been feeling off, could the solution be as simple as adjusting your fat intake?

Written by
Yongzi See
You feel down, irritable, and lack motivation. You’ve tried everything, but nothing seems to work.
Could increasing your intake of omega-3 fatty acids be the cure?
TL;DR
Omega-3s, essential fats, are vital for brain health and function
Studies show a link between low omega-3 levels and an increased risk of depression
Increasing omega-3 intake through diet or supplements may improve mood and cognitive function
What are Omega-3 Fatty Acids?

Essential fats, crucial for brain health and function
Influence how neurons communicate
Possess anti-inflammatory properties, vital for mood regulation
Inflammation is increasingly linked to depression
Key Types of Omega-3s
EPA (Eicosapentaenoic Acid): Reduces inflammation
DHA (Docosahexaenoic Acid): Crucial for brain health, eyesight, and heart function
ALA (Alpha-Linolenic Acid): Primarily an energy source, inefficiently converted to EPA and DHA
The Omega-3 and Depression Connection

Your brain needs omega-3s, particularly EPA and DHA, to function correctly.
Individuals experiencing depression may have insufficient levels of these essential fats.
This deficiency could disrupt brain cell communication, neurotransmitter production, and inflammatory responses, all of which play a role in mood regulation.
What the Research Says
Reduced Risk of Depression: Individuals with higher levels of omega-3s, especially EPA, were less likely to experience major depressive disorder
Improved Mood and Cognition: Higher doses of omega-3s (~4 grams/day) can improve motivational symptoms and cognitive function in people with depression
Enhanced Antidepressant Effects: Omega-3 fatty acid supplements combined with antidepressants were more effective in alleviating depressive symptoms than antidepressants alone
How to Increase Omega-3 Intake

The best way to increase your omega-3 intake is through a balanced diet and supplementation.
Dietary Changes
Fatty Fish: Salmon, mackerel, tuna, herring, and sardines are excellent sources of EPA and DHA
Nuts and Seeds: Flaxseed, chia seeds, and walnuts are good sources of ALA
Plant Oils: Flaxseed oil, soybean oil, and canola oil contain ALA
Supplementation
Consider supplements if you struggle to get enough omega-3s through your diet
Different types of omega-3 supplements are available, including:
Natural Fish Oil
Processed Fish Oil
Krill Oil
Green-Lipped Mussel Oil
ALA Oil
Cod Liver Oil
Algal Oil
Recommended Daily Intake of Omega-3s
The recommended daily intake of omega-3s varies depending on age, gender, and health status.
Conclusion
Omega-3 fatty acids, especially EPA, may play a significant role in mood regulation.
Ensuring adequate omega-3 intake through diet or supplementation can support mental health.
Schedule an OmegaCheck and consult a healthcare professional to determine the appropriate dosage and type of omega-3 for your needs.
References
https://www.researchgate.net/publication/340029802_Omega-3_fatty_acids_and_mental_health
https://my.clevelandclinic.org/health/articles/17290-omega-3-fatty-acids
https://mghpsychnews.org/omega-3-fatty-acids-improve-depression-motivation-and-cognition/
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1200403/full
https://www.psypost.org/higher-omega-3-levels-linked-to-lower-risk-of-depression-study-finds/
https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/
https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/fish-and-omega-3-fatty-acids
https://www.goodrx.com/omega-3-acid-ethyl-esters/omega-3-dosages
https://www.healthline.com/nutrition/omega-3-supplement-guide
https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/
https://healthpromotion.ucsd.edu/_files/topics/healthy-eating/omega3supp.pdf
https://www.nccih.nih.gov/health/omega3-supplements-what-you-need-to-know
https://www.mayoclinic.org/drugs-supplements-fish-oil/art-20364810
https://casatondemand.org/2022/08/10/7-lifestyle-factors-that-impact-mental-health/