Omega-3 and Depression: Could Your Mood Swings Be a Nutrient Deficiency?

Emerging research links low omega-3 levels to anxiety, depression, and cognitive decline. If you’ve been feeling off, could the solution be as simple as adjusting your fat intake?

Written By
Mito Team
February 7, 2025

You feel down, irritable, and lack motivation. You’ve tried everything, but nothing seems to work.

Could increasing your intake of omega-3 fatty acids be the cure?

TL;DR

  • Omega-3s, essential fats, are vital for brain health and function
  • Studies show a link between low omega-3 levels and an increased risk of depression
  • Increasing omega-3 intake through diet or supplements may improve mood and cognitive function

What are Omega-3 Fatty Acids?

  • Essential fats, crucial for brain health and function
  • Influence how neurons communicate
  • Possess anti-inflammatory properties, vital for mood regulation
  • Inflammation is increasingly linked to depression

Key Types of Omega-3s

  • EPA (Eicosapentaenoic Acid): Reduces inflammation
  • DHA (Docosahexaenoic Acid): Crucial for brain health, eyesight, and heart function
  • ALA (Alpha-Linolenic Acid): Primarily an energy source, inefficiently converted to EPA and DHA

The Omega-3 and Depression Connection

Your brain needs omega-3s, particularly EPA and DHA, to function correctly. 

Individuals experiencing depression may have insufficient levels of these essential fats.

This deficiency could disrupt brain cell communication, neurotransmitter production, and inflammatory responses, all of which play a role in mood regulation.  

What the Research Says

  • Reduced Risk of Depression: Individuals with higher levels of omega-3s, especially EPA, were less likely to experience major depressive disorder
  • Improved Mood and Cognition: Higher doses of omega-3s (~4 grams/day) can improve motivational symptoms and cognitive function in people with depression
  • Enhanced Antidepressant Effects: Omega-3 fatty acid supplements combined with antidepressants were more effective in alleviating depressive symptoms than antidepressants alone

How to Increase Omega-3 Intake

The best way to increase your omega-3 intake is through a balanced diet and supplementation.

Dietary Changes

  • Fatty Fish: Salmon, mackerel, tuna, herring, and sardines are excellent sources of EPA and DHA
  • Nuts and Seeds: Flaxseed, chia seeds, and walnuts are good sources of ALA
  • Plant Oils: Flaxseed oil, soybean oil, and canola oil contain ALA

Supplementation

  • Consider supplements if you struggle to get enough omega-3s through your diet
  • Different types of omega-3 supplements are available, including:
    • Natural Fish Oil  
    • Processed Fish Oil  
    • Krill Oil  
    • Green-Lipped Mussel Oil  
    • ALA Oil  
    • Cod Liver Oil  
    • Algal Oil 

Recommended Daily Intake of Omega-3s

The recommended daily intake of omega-3s varies depending on age, gender, and health status.

Conclusion

  • Omega-3 fatty acids, especially EPA, may play a significant role in mood regulation.  
  • Ensuring adequate omega-3 intake through diet or supplementation can support mental health.  
  • Schedule an OmegaCheck and consult a healthcare professional to determine the appropriate dosage and type of omega-3 for your needs.  
References

  1. (PDF) Omega-3 fatty acids and mental health - ResearchGate, accessed on February 6, 2025, https://www.researchgate.net/publication/340029802_Omega-3_fatty_acids_and_mental_health
  2. Omega 3 Fatty Acids and Mental Health: Canada - eMentalHealth.ca, accessed on February 6, 2025, https://www.ementalhealth.ca/Canada/Omega-3-Fatty-Acids-and-Mental-Health/index.php?m=article&ID=57146
  3. Omega-3 Fatty Acids & the Important Role They Play - Cleveland Clinic, accessed on February 6, 2025, https://my.clevelandclinic.org/health/articles/17290-omega-3-fatty-acids
  4. Omega-3 and Depression: Benefits, Side Effects, and Uses - Healthline, accessed on February 6, 2025, https://www.healthline.com/health/omega-3-depression
  5. High-Dose Omega-3 Fatty Acids Improve Aspects of Cognition in..., accessed on February 6, 2025, https://mghpsychnews.org/omega-3-fatty-acids-improve-depression-motivation-and-cognition/
  6. Omega-3 index as risk factor in psychiatric diseases: a narrative review - Frontiers, accessed on February 6, 2025, https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1200403/full
  7. Higher omega-3 levels linked to lower risk of depression, study finds, accessed on February 6, 2025, https://www.psypost.org/higher-omega-3-levels-linked-to-lower-risk-of-depression-study-finds/
  8. www.frontiersin.org, accessed on February 6, 2025, https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.933704/full#:~:text=A%20number%20of%20epidemiological%20studies,controls%20(53%2C%2054).  
  9. Omega-3 Fatty Acids for Major Depressive Disorder: A Systematic Review | RAND, accessed on February 6, 2025, https://www.rand.org/pubs/research_reports/RR1079.html  
  10. Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials | The British Journal of Psychiatry - Cambridge University Press & Assessment, accessed on February 6, 2025, https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/omega3-and-polyunsaturated-fat-for-prevention-of-depression-and-anxiety-symptoms-systematic-review-and-metaanalysis-of-randomised-trials/B074BDC1CF8D59D234E30B961E9EADF8  
  11. Omega-3 Fatty Acids for Depression in the Elderly and Patients with Dementia: A Systematic Review and Meta-Analysis - MDPI, accessed on February 6, 2025, https://www.mdpi.com/2227-9032/12/5/536  
  12. Omega-3 Fatty Acids for Mood Disorders and Other Psychiatric Conditions - YouTube, accessed on February 6, 2025, https://www.youtube.com/watch?v=ueYINZYPBm0  
  13. Omega-3 Fatty Acids - Consumer - NIH Office of Dietary Supplements, accessed on February 6, 2025, https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/  
  14. Fish and Omega-3 Fatty Acids | American Heart Association, accessed on February 6, 2025, https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/fish-and-omega-3-fatty-acids  
  15. Your GoodRx Guide for Omega-3 Dosages: How Much Is Too Much Daily?, accessed on February 6, 2025, https://www.goodrx.com/omega-3-acid-ethyl-esters/omega-3-dosages  
  16. Omega-3 Supplement Guide: What to Buy and Why - Healthline, accessed on February 6, 2025, https://www.healthline.com/nutrition/omega-3-supplement-guide  
  17. Omega-3 Fatty Acids - Health Professional Fact Sheet - NIH Office of Dietary Supplements, accessed on February 6, 2025, https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/  
  18. Choosing an Omega-3 Supplement - Health Promotion Services, accessed on February 6, 2025, https://healthpromotion.ucsd.edu/_files/topics/healthy-eating/omega3supp.pdf  
  19. Omega-3 Supplements: What You Need To Know | NCCIH, accessed on February 6, 2025, https://www.nccih.nih.gov/health/omega3-supplements-what-you-need-to-know  
  20. Fish oil - Mayo Clinic, accessed on February 6, 2025, https://www.mayoclinic.org/drugs-supplements-fish-oil/art-20364810  
  21. Omega 3 Fatty Acids: Supplement Uses, Warnings, Side Effects, Dosage - MedicineNet, accessed on February 6, 2025, https://www.medicinenet.com/omega_3_fatty_acids/article.htm  
  22. Fish oil side effects: How much is too much? - MedicalNewsToday, accessed on February 6, 2025, https://www.medicalnewstoday.com/articles/326206  
  23. 7 Lifestyle Factors That Impact Mental Health - CASAT OnDemand, accessed on February 6, 2025, https://casatondemand.org/2022/08/10/7-lifestyle-factors-that-impact-mental-health/

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