Your guide to Urea.
Understand the role of Urea in your health and longevity with Mito Health's comprehensive biomarker analysis. Our detailed reports cover key biomarkers, providing essential insights to help you make informed decisions for a healthier, longer life.
What is Urea?
Urea, also known as BUN, is a compound containing nitrogen that is produced in the liver as a result of protein metabolism and the removal of toxic ammonia from our body. Most of the urea is removed by the kidneys, and a small amount through the intestines.
Higher levels of urea in the blood can occur when kidney clearance decreases (if kidney function is reduced), but can also occur in dehydration or in situations where there is increased protein breakdown.
Increase protein breakdown can occur when there is excess protein from the diet or in digestive tract conditions or in conditions where there is increased breakdown of your body tissues (catabolic states).
What does it assess?
Blood Urea Nitrogen (BUN), assesses how well the kidneys are filtering waste products from the blood. Urea is a byproduct of protein metabolism produced in the liver and excreted by the kidneys.
BUN levels can reveal information about kidney function, hydration status, liver health, and dietary protein intake. Elevated urea may indicate decreased kidney function or increased protein breakdown, while low levels can suggest reduced protein intake or liver function issues.
How do I optimize my Urea levels?
Excessive protein can increase urea production, while too little protein can lower urea levels.
Aim for a balanced, individualized protein intake based on your body’s needs, typically around 0.8–1.2 grams per kilogram of body weight, unless directed otherwise.
Dehydration can concentrate urea in the blood, elevating BUN levels. Drinking sufficient water supports kidney function and helps flush urea from the body.
Adjust water intake according to activity level, climate, and health status.
While adequate protein is essential, overuse of protein powders or supplements can raise urea levels.
Stick to whole food sources of protein where possible.
What do high and low Urea levels mean?
Elevated urea can indicate decreased kidney function, dehydration, or excessive protein breakdown due to a high-protein diet, tissue breakdown, or conditions like gastrointestinal bleeding. High urea may also be a sign of kidney disease or damage if chronic.
Low urea levels can reflect inadequate protein intake, often due to dietary choices or malnutrition. They may also indicate impaired liver function, as the liver produces urea from protein metabolism. Additionally, certain conditions, such as overhydration, may dilute urea in the blood.
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